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Excretion of unchanged volatile organic compounds (toluene, ethylbenzene, xylene and mesitylene) in urine as result of experimental human volunteer exposure.
Int Arch Occup Environ Health. 2008 Feb; 81(4):443-9.IA

Abstract

OBJECTIVES

To investigate elimination of unchanged volatile organic compounds (VOC's) through urine and the use of respective data for occupational exposure assessment, six volunteers were exposed under controlled conditions to toluene (TOL), ethylbenzene (EB), xylene (XYL) and mesitylene (MES) at concentrations ranging from 20 to 200 mg/m(3). The study was to elicit the toxicokinetic data and compare the precision of VOC's exposure assessment based on determining unchanged compounds in blood, urine and their metabolites in urine.

METHODS

During and after exposure blood and urine samples were analysed by gas chromatography using the headspace and SPME headspace technique

RESULTS

The kinetics of VOC's elimination in urine complied with an open two-compartment model. The (half-time) T (1/2)values varied from 0.45 to 0.88 h for phase I and from 6.7 to 19.2 h for phase II. The precision of the method for unchanged VOC's was similar to that based on unchanged compounds in blood and better than their main metabolites in urine.

CONCLUSION

The obtained result indicate that determining unchanged VOC's in urine can be used as an exposure test even in the ranges of VOC's in the air that are much lower than the current TWA for occupational exposure.

Authors+Show Affiliations

Department of Chemical Hazard, Institute of Occupational Medicine, Lodz, Poland. beatajan@imp.lodz.plNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17680265

Citation

Janasik, Beata, et al. "Excretion of Unchanged Volatile Organic Compounds (toluene, Ethylbenzene, Xylene and Mesitylene) in Urine as Result of Experimental Human Volunteer Exposure." International Archives of Occupational and Environmental Health, vol. 81, no. 4, 2008, pp. 443-9.
Janasik B, Jakubowski M, Jałowiecki P. Excretion of unchanged volatile organic compounds (toluene, ethylbenzene, xylene and mesitylene) in urine as result of experimental human volunteer exposure. Int Arch Occup Environ Health. 2008;81(4):443-9.
Janasik, B., Jakubowski, M., & Jałowiecki, P. (2008). Excretion of unchanged volatile organic compounds (toluene, ethylbenzene, xylene and mesitylene) in urine as result of experimental human volunteer exposure. International Archives of Occupational and Environmental Health, 81(4), 443-9.
Janasik B, Jakubowski M, Jałowiecki P. Excretion of Unchanged Volatile Organic Compounds (toluene, Ethylbenzene, Xylene and Mesitylene) in Urine as Result of Experimental Human Volunteer Exposure. Int Arch Occup Environ Health. 2008;81(4):443-9. PubMed PMID: 17680265.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Excretion of unchanged volatile organic compounds (toluene, ethylbenzene, xylene and mesitylene) in urine as result of experimental human volunteer exposure. AU - Janasik,Beata, AU - Jakubowski,Marek, AU - Jałowiecki,Piotr, Y1 - 2007/08/07/ PY - 2007/02/01/received PY - 2007/07/11/accepted PY - 2007/8/8/pubmed PY - 2008/6/12/medline PY - 2007/8/8/entrez SP - 443 EP - 9 JF - International archives of occupational and environmental health JO - Int Arch Occup Environ Health VL - 81 IS - 4 N2 - OBJECTIVES: To investigate elimination of unchanged volatile organic compounds (VOC's) through urine and the use of respective data for occupational exposure assessment, six volunteers were exposed under controlled conditions to toluene (TOL), ethylbenzene (EB), xylene (XYL) and mesitylene (MES) at concentrations ranging from 20 to 200 mg/m(3). The study was to elicit the toxicokinetic data and compare the precision of VOC's exposure assessment based on determining unchanged compounds in blood, urine and their metabolites in urine. METHODS: During and after exposure blood and urine samples were analysed by gas chromatography using the headspace and SPME headspace technique RESULTS: The kinetics of VOC's elimination in urine complied with an open two-compartment model. The (half-time) T (1/2)values varied from 0.45 to 0.88 h for phase I and from 6.7 to 19.2 h for phase II. The precision of the method for unchanged VOC's was similar to that based on unchanged compounds in blood and better than their main metabolites in urine. CONCLUSION: The obtained result indicate that determining unchanged VOC's in urine can be used as an exposure test even in the ranges of VOC's in the air that are much lower than the current TWA for occupational exposure. SN - 0340-0131 UR - https://www.unboundmedicine.com/medline/citation/17680265/Excretion_of_unchanged_volatile_organic_compounds__toluene_ethylbenzene_xylene_and_mesitylene__in_urine_as_result_of_experimental_human_volunteer_exposure_ L2 - https://dx.doi.org/10.1007/s00420-007-0233-9 DB - PRIME DP - Unbound Medicine ER -