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[Association of polymorphism on HLA-DRB1*04 alleles with outcome of hepatitis B virus infection].
Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007 Aug; 24(4):467-9.ZY

Abstract

OBJECTIVE

To investigate the relation between the alleles of HLA-DRB1*04 and outcome of HBV infection.

METHODS

The alleles of HLA-DRB1*04 were detected by polymerase chain reaction-sequence specific primer (PCR-SSP). The frequency of allele of HLA-DRB1*04 in four groups[106 asymptomatic HBsAg carriers (group ASC), 93 chronic hepatitis B patients (group CHB), 77 patients with hepatitis B cirrhosis and 102 cases of spontaneous recovery after HBV infection (control group)] were studied, and the frequency of that in different replication of HBV was also studied.

RESULTS

The frequency of allele of HLA-RB1*04 in groups ASC, CHB and hepatitis B cirrhosis was markedly higher than that of control group (25.94%, 26.34%, 27.92% respectively versus 14.22%, P< 0.01); the frequency of HLA-DRB1*0401 in groups ASC, CHB and hepatitis B cirrhosis was also higher than that of control group (20.91%, 24.49%, 22.09% respectively versus 8.62%, P< 0.05, P< 0.01,P< 0.05 respectively); the frequency of HLA-DRB1*0405 in groups ASC, CHB and hepatitis B cirrhosis was lower than that of control group (3.64%, 2.04%, 3.49% respectively versus 15.52%, P< 0.01, P< 0.01, P< 0.05 respectively). There was no statistical significance in the allele frequency of HLA-DRB1*04 among groups ASC, CHB and hepatitis B cirrhosis (P> 0.05), and the same result was observed in different replication of HBV (P> 0.05).

CONCLUSION

HLA-DRB1*04 gene is one of the factors which determine the outcomes of HBV infection, while it has no influence on HBV replication.

Authors+Show Affiliations

Department of Clinical Laboratory, the Third Xiangya Hospital, Central South University, Changsha, Hunan, 410013 P. R. China. mshs648@sohu.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

17680546

Citation

Song, Ming-sheng, et al. "[Association of Polymorphism On HLA-DRB1*04 Alleles With Outcome of Hepatitis B Virus Infection]." Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, vol. 24, no. 4, 2007, pp. 467-9.
Song MS, Li HW, Peng HY, et al. [Association of polymorphism on HLA-DRB1*04 alleles with outcome of hepatitis B virus infection]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007;24(4):467-9.
Song, M. S., Li, H. W., Peng, H. Y., Duan, B. N., Chen, H., & Xu, L. Q. (2007). [Association of polymorphism on HLA-DRB1*04 alleles with outcome of hepatitis B virus infection]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi = Zhonghua Yixue Yichuanxue Zazhi = Chinese Journal of Medical Genetics, 24(4), 467-9.
Song MS, et al. [Association of Polymorphism On HLA-DRB1*04 Alleles With Outcome of Hepatitis B Virus Infection]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2007;24(4):467-9. PubMed PMID: 17680546.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Association of polymorphism on HLA-DRB1*04 alleles with outcome of hepatitis B virus infection]. AU - Song,Ming-sheng, AU - Li,Hong-wei, AU - Peng,Huai-yan, AU - Duan,Bing-nan, AU - Chen,Hui, AU - Xu,Ling-qing, PY - 2007/8/8/pubmed PY - 2009/3/28/medline PY - 2007/8/8/entrez SP - 467 EP - 9 JF - Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics JO - Zhonghua Yi Xue Yi Chuan Xue Za Zhi VL - 24 IS - 4 N2 - OBJECTIVE: To investigate the relation between the alleles of HLA-DRB1*04 and outcome of HBV infection. METHODS: The alleles of HLA-DRB1*04 were detected by polymerase chain reaction-sequence specific primer (PCR-SSP). The frequency of allele of HLA-DRB1*04 in four groups[106 asymptomatic HBsAg carriers (group ASC), 93 chronic hepatitis B patients (group CHB), 77 patients with hepatitis B cirrhosis and 102 cases of spontaneous recovery after HBV infection (control group)] were studied, and the frequency of that in different replication of HBV was also studied. RESULTS: The frequency of allele of HLA-RB1*04 in groups ASC, CHB and hepatitis B cirrhosis was markedly higher than that of control group (25.94%, 26.34%, 27.92% respectively versus 14.22%, P< 0.01); the frequency of HLA-DRB1*0401 in groups ASC, CHB and hepatitis B cirrhosis was also higher than that of control group (20.91%, 24.49%, 22.09% respectively versus 8.62%, P< 0.05, P< 0.01,P< 0.05 respectively); the frequency of HLA-DRB1*0405 in groups ASC, CHB and hepatitis B cirrhosis was lower than that of control group (3.64%, 2.04%, 3.49% respectively versus 15.52%, P< 0.01, P< 0.01, P< 0.05 respectively). There was no statistical significance in the allele frequency of HLA-DRB1*04 among groups ASC, CHB and hepatitis B cirrhosis (P> 0.05), and the same result was observed in different replication of HBV (P> 0.05). CONCLUSION: HLA-DRB1*04 gene is one of the factors which determine the outcomes of HBV infection, while it has no influence on HBV replication. SN - 1003-9406 UR - https://www.unboundmedicine.com/medline/citation/17680546/[Association_of_polymorphism_on_HLA_DRB1_04_alleles_with_outcome_of_hepatitis_B_virus_infection]_ L2 - http://www.diseaseinfosearch.org/result/3332 DB - PRIME DP - Unbound Medicine ER -