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Does metoprolol inhibit the cortical spreading depression? Acute effects of systematic metropol on CSD in rats.
Cephalalgia 2007; 27(9):1010-3C

Abstract

Cortical spreading depression (CSD) is supposed to be the underlying biological basis of the migraine aura. Metoprolol was proven to be effective in migraine prophylaxis in clinical trials, but its mechanism of action has not been clarified yet. We studied direct effects of metoprolol on a continuous CSD induction model in rats. Six adult Wistar rats were anaesthetized with intraperitoneal thiopental (50 mg/kg). CSD was induced with application of 1 m KCL through a burr hole into the left frontal dura-mater, and recorded by an Ag/AgCl DC electrode on the left parietal dura-mater. After a basal recording of CSD induction during the first 40-min period, metoprolol (5 mg/kg) was infused within 4 min. Then DC recordings were maintained for a further 120 min. Any significant differences in total number and duration of CSDs before and after metoprolol administration were not detected. This study suggests that the mode of action of metoprolol in prophylaxis is not via direct CSD inhibition.

Authors+Show Affiliations

Headache Unit, Department of Neurology, Medical Faculty, Kocaeli University, Kocaeli, Turkey. drmuratalemdar@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17681024

Citation

Alemdar, M, et al. "Does Metoprolol Inhibit the Cortical Spreading Depression? Acute Effects of Systematic Metropol On CSD in Rats." Cephalalgia : an International Journal of Headache, vol. 27, no. 9, 2007, pp. 1010-3.
Alemdar M, Akman O, Selekler H, et al. Does metoprolol inhibit the cortical spreading depression? Acute effects of systematic metropol on CSD in rats. Cephalalgia. 2007;27(9):1010-3.
Alemdar, M., Akman, O., Selekler, H., Komsuoğlu, S., & Ateş, N. (2007). Does metoprolol inhibit the cortical spreading depression? Acute effects of systematic metropol on CSD in rats. Cephalalgia : an International Journal of Headache, 27(9), pp. 1010-3.
Alemdar M, et al. Does Metoprolol Inhibit the Cortical Spreading Depression? Acute Effects of Systematic Metropol On CSD in Rats. Cephalalgia. 2007;27(9):1010-3. PubMed PMID: 17681024.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Does metoprolol inhibit the cortical spreading depression? Acute effects of systematic metropol on CSD in rats. AU - Alemdar,M, AU - Akman,O, AU - Selekler,H M, AU - Komsuoğlu,S S, AU - Ateş,N, Y1 - 2007/08/06/ PY - 2007/8/8/pubmed PY - 2007/11/14/medline PY - 2007/8/8/entrez SP - 1010 EP - 3 JF - Cephalalgia : an international journal of headache JO - Cephalalgia VL - 27 IS - 9 N2 - Cortical spreading depression (CSD) is supposed to be the underlying biological basis of the migraine aura. Metoprolol was proven to be effective in migraine prophylaxis in clinical trials, but its mechanism of action has not been clarified yet. We studied direct effects of metoprolol on a continuous CSD induction model in rats. Six adult Wistar rats were anaesthetized with intraperitoneal thiopental (50 mg/kg). CSD was induced with application of 1 m KCL through a burr hole into the left frontal dura-mater, and recorded by an Ag/AgCl DC electrode on the left parietal dura-mater. After a basal recording of CSD induction during the first 40-min period, metoprolol (5 mg/kg) was infused within 4 min. Then DC recordings were maintained for a further 120 min. Any significant differences in total number and duration of CSDs before and after metoprolol administration were not detected. This study suggests that the mode of action of metoprolol in prophylaxis is not via direct CSD inhibition. SN - 0333-1024 UR - https://www.unboundmedicine.com/medline/citation/17681024/Does_metoprolol_inhibit_the_cortical_spreading_depression_Acute_effects_of_systematic_metropol_on_CSD_in_rats_ L2 - http://journals.sagepub.com/doi/full/10.1111/j.1468-2982.2007.01390.x?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -