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Percentages of positive cores, cancer length and Gleason grade 4/5 cancer in systematic sextant biopsy are all predictive of adverse pathology and biochemical failure after radical prostatectomy.
Int J Urol. 2007 Aug; 14(8):713-8.IJ

Abstract

AIM

We investigated whether the quantitative parameters of systematic sextant biopsies were predictive of either adverse pathological findings or disease recurrence after radical prostatectomy (RP).

METHODS

We retrospectively evaluated a total of 117 men with untreated prostate cancer whose needle biopsies were matched with RP specimens. The pretreatment parameters of the serum prostate-specific antigen (PSA), the PSA density, the percentage of positive biopsy cores, the percentage of cancer length and the percentage of Gleason grade 4/5 cancer in the biopsy were determined and compared with the pathological features of prostate cancer in RP specimens. These pretreatment parameters and pathological factors in the RP specimens, including the cancer volume, the percentage of Gleason grade 4/5 cancer, the positive surgical margin and the seminal vesicle invasion were evaluated for their ability to predict the disease recurrence.

RESULTS

The percentages of positive biopsy cores, the Gleason grade 4/5 cancer in the biopsy and the cancer length in the biopsy had a weak correlation with the cancer volume in RP specimens (r = 0.373, 0.345, 0.408, respectively). All quantitative biopsy parameters were strongly predictive of the non-organ-confined status, the positive surgical margin and the seminal vesicle invasion in the logistic regression analysis. The percentage of positive biopsy cores and the percentage of Gleason grade 4/5 cancer in the biopsy predicted biochemical failure after RP.

CONCLUSION

These results indicate that quantitative biopsy parameters are independent predictors of the adverse pathology of prostate cancers and disease recurrence after RP.

Authors+Show Affiliations

Department of Urology, Kurume University School of Medicine, Kurume, Japan. suekane@med.kurume-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17681061

Citation

Suekane, Shigetaka, et al. "Percentages of Positive Cores, Cancer Length and Gleason Grade 4/5 Cancer in Systematic Sextant Biopsy Are All Predictive of Adverse Pathology and Biochemical Failure After Radical Prostatectomy." International Journal of Urology : Official Journal of the Japanese Urological Association, vol. 14, no. 8, 2007, pp. 713-8.
Suekane S, Noguchi M, Nakashima O, et al. Percentages of positive cores, cancer length and Gleason grade 4/5 cancer in systematic sextant biopsy are all predictive of adverse pathology and biochemical failure after radical prostatectomy. Int J Urol. 2007;14(8):713-8.
Suekane, S., Noguchi, M., Nakashima, O., Yamada, S., Kojiro, M., & Matsuoka, K. (2007). Percentages of positive cores, cancer length and Gleason grade 4/5 cancer in systematic sextant biopsy are all predictive of adverse pathology and biochemical failure after radical prostatectomy. International Journal of Urology : Official Journal of the Japanese Urological Association, 14(8), 713-8.
Suekane S, et al. Percentages of Positive Cores, Cancer Length and Gleason Grade 4/5 Cancer in Systematic Sextant Biopsy Are All Predictive of Adverse Pathology and Biochemical Failure After Radical Prostatectomy. Int J Urol. 2007;14(8):713-8. PubMed PMID: 17681061.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Percentages of positive cores, cancer length and Gleason grade 4/5 cancer in systematic sextant biopsy are all predictive of adverse pathology and biochemical failure after radical prostatectomy. AU - Suekane,Shigetaka, AU - Noguchi,Masanori, AU - Nakashima,Osamu, AU - Yamada,Satoko, AU - Kojiro,Masamichi, AU - Matsuoka,Kei, PY - 2007/8/8/pubmed PY - 2008/2/12/medline PY - 2007/8/8/entrez SP - 713 EP - 8 JF - International journal of urology : official journal of the Japanese Urological Association JO - Int J Urol VL - 14 IS - 8 N2 - AIM: We investigated whether the quantitative parameters of systematic sextant biopsies were predictive of either adverse pathological findings or disease recurrence after radical prostatectomy (RP). METHODS: We retrospectively evaluated a total of 117 men with untreated prostate cancer whose needle biopsies were matched with RP specimens. The pretreatment parameters of the serum prostate-specific antigen (PSA), the PSA density, the percentage of positive biopsy cores, the percentage of cancer length and the percentage of Gleason grade 4/5 cancer in the biopsy were determined and compared with the pathological features of prostate cancer in RP specimens. These pretreatment parameters and pathological factors in the RP specimens, including the cancer volume, the percentage of Gleason grade 4/5 cancer, the positive surgical margin and the seminal vesicle invasion were evaluated for their ability to predict the disease recurrence. RESULTS: The percentages of positive biopsy cores, the Gleason grade 4/5 cancer in the biopsy and the cancer length in the biopsy had a weak correlation with the cancer volume in RP specimens (r = 0.373, 0.345, 0.408, respectively). All quantitative biopsy parameters were strongly predictive of the non-organ-confined status, the positive surgical margin and the seminal vesicle invasion in the logistic regression analysis. The percentage of positive biopsy cores and the percentage of Gleason grade 4/5 cancer in the biopsy predicted biochemical failure after RP. CONCLUSION: These results indicate that quantitative biopsy parameters are independent predictors of the adverse pathology of prostate cancers and disease recurrence after RP. SN - 0919-8172 UR - https://www.unboundmedicine.com/medline/citation/17681061/Percentages_of_positive_cores_cancer_length_and_Gleason_grade_4/5_cancer_in_systematic_sextant_biopsy_are_all_predictive_of_adverse_pathology_and_biochemical_failure_after_radical_prostatectomy_ L2 - https://doi.org/10.1111/j.1442-2042.2007.01809.x DB - PRIME DP - Unbound Medicine ER -