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Comparative efficacy of intralesional sodium stibogluconate (SSG) alone and its combination with intramuscular SSG to treat localized cutaneous leishmaniasis: Results of a pilot study.
Indian J Dermatol Venereol Leprol. 2007 Jul-Aug; 73(4):280.IJ

Abstract

BACKGROUND

Intralesional sodium stibogluconate (SSG) has become first line therapy for localized cutaneous leishmaniasis (LCL).

AIMS

This study compares the efficacy of intralesional SSG given alone with that of intralesional SSG combined with intramuscular SSG.

METHODS

Thirty-two patients aged between 5-56 years were included in the study. The first group received three injections of intralesional SSG on alternate days while the other group received three injections of intralesional SSG similar to the first group and the rest of the calculated dose as a simultaneous, intramuscular injection. Patients were followed up every four weeks to assess for cure/ the need for repeating the treatment.

RESULTS

Five patients from group 1 having small nodular lesions of < six months duration were cured after 1-2 treatment cycles. However, six patients with mucosal lesions, large lesions and lesions of > six months duration needed 3-5 treatment schedules. Most plaques and mucosal lesions in seven patients in group 2 cleared with two treatment cycles.

CONCLUSION

Intralesional combined with intramuscular SSG appears more effective in LCL and gave qualitatively superior healing than intralesional SSG given alone.

Authors+Show Affiliations

Department of Dermatology, Venereology and Leprosy, Indira Gandhi Medical College, Shimla, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

17682296

Citation

Negi, Ajeet K., et al. "Comparative Efficacy of Intralesional Sodium Stibogluconate (SSG) Alone and Its Combination With Intramuscular SSG to Treat Localized Cutaneous Leishmaniasis: Results of a Pilot Study." Indian Journal of Dermatology, Venereology and Leprology, vol. 73, no. 4, 2007, p. 280.
Negi AK, Sharma NL, Mahajan VK, et al. Comparative efficacy of intralesional sodium stibogluconate (SSG) alone and its combination with intramuscular SSG to treat localized cutaneous leishmaniasis: Results of a pilot study. Indian J Dermatol Venereol Leprol. 2007;73(4):280.
Negi, A. K., Sharma, N. L., Mahajan, V. K., Ranjan, N., & Kanga, A. K. (2007). Comparative efficacy of intralesional sodium stibogluconate (SSG) alone and its combination with intramuscular SSG to treat localized cutaneous leishmaniasis: Results of a pilot study. Indian Journal of Dermatology, Venereology and Leprology, 73(4), 280.
Negi AK, et al. Comparative Efficacy of Intralesional Sodium Stibogluconate (SSG) Alone and Its Combination With Intramuscular SSG to Treat Localized Cutaneous Leishmaniasis: Results of a Pilot Study. Indian J Dermatol Venereol Leprol. 2007 Jul-Aug;73(4):280. PubMed PMID: 17682296.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative efficacy of intralesional sodium stibogluconate (SSG) alone and its combination with intramuscular SSG to treat localized cutaneous leishmaniasis: Results of a pilot study. AU - Negi,Ajeet K, AU - Sharma,Nand Lal, AU - Mahajan,Vikram K, AU - Ranjan,Nitin, AU - Kanga,Anil K, PY - 2007/8/9/pubmed PY - 2007/9/21/medline PY - 2007/8/9/entrez SP - 280 EP - 280 JF - Indian journal of dermatology, venereology and leprology JO - Indian J Dermatol Venereol Leprol VL - 73 IS - 4 N2 - BACKGROUND: Intralesional sodium stibogluconate (SSG) has become first line therapy for localized cutaneous leishmaniasis (LCL). AIMS: This study compares the efficacy of intralesional SSG given alone with that of intralesional SSG combined with intramuscular SSG. METHODS: Thirty-two patients aged between 5-56 years were included in the study. The first group received three injections of intralesional SSG on alternate days while the other group received three injections of intralesional SSG similar to the first group and the rest of the calculated dose as a simultaneous, intramuscular injection. Patients were followed up every four weeks to assess for cure/ the need for repeating the treatment. RESULTS: Five patients from group 1 having small nodular lesions of < six months duration were cured after 1-2 treatment cycles. However, six patients with mucosal lesions, large lesions and lesions of > six months duration needed 3-5 treatment schedules. Most plaques and mucosal lesions in seven patients in group 2 cleared with two treatment cycles. CONCLUSION: Intralesional combined with intramuscular SSG appears more effective in LCL and gave qualitatively superior healing than intralesional SSG given alone. SN - 0973-3922 UR - https://www.unboundmedicine.com/medline/citation/17682296/Comparative_efficacy_of_intralesional_sodium_stibogluconate__SSG__alone_and_its_combination_with_intramuscular_SSG_to_treat_localized_cutaneous_leishmaniasis:_Results_of_a_pilot_study_ L2 - http://www.diseaseinfosearch.org/result/4166 DB - PRIME DP - Unbound Medicine ER -