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Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents.
Semin Liver Dis 2007; 27(3):312-8SL

Abstract

This review covers the diagnosis and epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) in children and adolescents. Pediatric NAFLD remains a clinicopathologic diagnosis requiring direct demonstration of liver steatosis and the exclusion of other causes of fatty liver and/or hepatitis. NAFLD is the most common cause of chronic liver disease in children. The number of children with NAFLD presents a major public health crisis. Age, sex, race, ethnicity, and body habitus all influence the risk for NAFLD. The epidemiology of pediatric NAFLD should inform future attempts to develop rigorously evaluated screening protocols. Moreover, these data should guide efforts to delineate the pathophysiology in children and adolescents. Our future ability to prevent and treat pediatric NAFLD is dependent upon such work.

Authors+Show Affiliations

Division of Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of California, San Diego, and Rady Children's Hospital and Health Center, San Diego, California, USA.

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17682977

Citation

Schwimmer, Jeffrey B.. "Definitive Diagnosis and Assessment of Risk for Nonalcoholic Fatty Liver Disease in Children and Adolescents." Seminars in Liver Disease, vol. 27, no. 3, 2007, pp. 312-8.
Schwimmer JB. Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents. Semin Liver Dis. 2007;27(3):312-8.
Schwimmer, J. B. (2007). Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents. Seminars in Liver Disease, 27(3), pp. 312-8.
Schwimmer JB. Definitive Diagnosis and Assessment of Risk for Nonalcoholic Fatty Liver Disease in Children and Adolescents. Semin Liver Dis. 2007;27(3):312-8. PubMed PMID: 17682977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Definitive diagnosis and assessment of risk for nonalcoholic fatty liver disease in children and adolescents. A1 - Schwimmer,Jeffrey B, PY - 2007/8/9/pubmed PY - 2007/10/27/medline PY - 2007/8/9/entrez SP - 312 EP - 8 JF - Seminars in liver disease JO - Semin. Liver Dis. VL - 27 IS - 3 N2 - This review covers the diagnosis and epidemiology of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) in children and adolescents. Pediatric NAFLD remains a clinicopathologic diagnosis requiring direct demonstration of liver steatosis and the exclusion of other causes of fatty liver and/or hepatitis. NAFLD is the most common cause of chronic liver disease in children. The number of children with NAFLD presents a major public health crisis. Age, sex, race, ethnicity, and body habitus all influence the risk for NAFLD. The epidemiology of pediatric NAFLD should inform future attempts to develop rigorously evaluated screening protocols. Moreover, these data should guide efforts to delineate the pathophysiology in children and adolescents. Our future ability to prevent and treat pediatric NAFLD is dependent upon such work. SN - 0272-8087 UR - https://www.unboundmedicine.com/medline/citation/17682977/Definitive_diagnosis_and_assessment_of_risk_for_nonalcoholic_fatty_liver_disease_in_children_and_adolescents_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-2007-985075 DB - PRIME DP - Unbound Medicine ER -