Tags

Type your tag names separated by a space and hit enter

Oncological and functional results of antegrade radical retropubic prostatectomy for the treatment of clinically localised prostate cancer.
Eur Urol. 2008 Mar; 53(3):554-61.EU

Abstract

OBJECTIVES

To present the oncological outcome of the antegrade radical prostatectomy in the whole series of consecutive patients treated over an 18-yr period, and to report the functional results and complications of the last 488 patients.

PATIENTS AND METHODS

We reviewed the clinicopathological data of 845 patients treated between 1988 and 2005. Complete data on continence, potency, and complication were available on the last 488 patients treated between 2000 and 2005.

RESULTS

Positive surgical margins were detected in 12.8% of patients. The mean follow-up was 49 mo. The 8-yr biochemical recurrence-free survival rates were 84.1% for pT2, 69.9% for pT3a, and 37.3% for pT3b disease (p<0.0001). The multivariate analysis showed stage, PSA, and Gleason score as significant independent predictors of biochemical recurrence-free survival. After 12 mo, 94.1% of patients were continent, and 69.6% of patients who had bilateral nerve-sparing prostatectomy were potent. Mean estimated blood loss was 223 cc; overall incidence of complication was lower than 15%.

CONCLUSIONS

Antegrade radical prostatectomy provides a low incidence of positive margins and an optimal cancer control. This technique can provide a low incidence of complications, reduced blood loss, and optimal functional results in terms of recovery of continence owing to a complete definition of the anatomical boundaries of the apex. Moreover, it can provide a less challenging nerve-sparing procedure with similar results to those reported by the retrograde approach.

Authors+Show Affiliations

Department of Urology, University of Florence, Careggi Hospital, Florence, Italy. carini@unifi.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17683854

Citation

Carini, Marco, et al. "Oncological and Functional Results of Antegrade Radical Retropubic Prostatectomy for the Treatment of Clinically Localised Prostate Cancer." European Urology, vol. 53, no. 3, 2008, pp. 554-61.
Carini M, Masieri L, Minervini A, et al. Oncological and functional results of antegrade radical retropubic prostatectomy for the treatment of clinically localised prostate cancer. Eur Urol. 2008;53(3):554-61.
Carini, M., Masieri, L., Minervini, A., Lapini, A., & Serni, S. (2008). Oncological and functional results of antegrade radical retropubic prostatectomy for the treatment of clinically localised prostate cancer. European Urology, 53(3), 554-61.
Carini M, et al. Oncological and Functional Results of Antegrade Radical Retropubic Prostatectomy for the Treatment of Clinically Localised Prostate Cancer. Eur Urol. 2008;53(3):554-61. PubMed PMID: 17683854.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oncological and functional results of antegrade radical retropubic prostatectomy for the treatment of clinically localised prostate cancer. AU - Carini,Marco, AU - Masieri,Lorenzo, AU - Minervini,Andrea, AU - Lapini,Alberto, AU - Serni,Sergio, Y1 - 2007/07/16/ PY - 2007/03/13/received PY - 2007/07/03/accepted PY - 2007/8/9/pubmed PY - 2008/5/14/medline PY - 2007/8/9/entrez SP - 554 EP - 61 JF - European urology JO - Eur Urol VL - 53 IS - 3 N2 - OBJECTIVES: To present the oncological outcome of the antegrade radical prostatectomy in the whole series of consecutive patients treated over an 18-yr period, and to report the functional results and complications of the last 488 patients. PATIENTS AND METHODS: We reviewed the clinicopathological data of 845 patients treated between 1988 and 2005. Complete data on continence, potency, and complication were available on the last 488 patients treated between 2000 and 2005. RESULTS: Positive surgical margins were detected in 12.8% of patients. The mean follow-up was 49 mo. The 8-yr biochemical recurrence-free survival rates were 84.1% for pT2, 69.9% for pT3a, and 37.3% for pT3b disease (p<0.0001). The multivariate analysis showed stage, PSA, and Gleason score as significant independent predictors of biochemical recurrence-free survival. After 12 mo, 94.1% of patients were continent, and 69.6% of patients who had bilateral nerve-sparing prostatectomy were potent. Mean estimated blood loss was 223 cc; overall incidence of complication was lower than 15%. CONCLUSIONS: Antegrade radical prostatectomy provides a low incidence of positive margins and an optimal cancer control. This technique can provide a low incidence of complications, reduced blood loss, and optimal functional results in terms of recovery of continence owing to a complete definition of the anatomical boundaries of the apex. Moreover, it can provide a less challenging nerve-sparing procedure with similar results to those reported by the retrograde approach. SN - 0302-2838 UR - https://www.unboundmedicine.com/medline/citation/17683854/Oncological_and_functional_results_of_antegrade_radical_retropubic_prostatectomy_for_the_treatment_of_clinically_localised_prostate_cancer_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0302-2838(07)00909-8 DB - PRIME DP - Unbound Medicine ER -