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The immunological role of the outer membrane proteins of non-typable Hemophilus influenzae in otitis media with effusion in children.
Eur Arch Otorhinolaryngol. 1991; 248(8):483-6.EA

Abstract

Specific IgG and IgA antibodies against the outer membrane proteins of non-typable Hemophilus influenzae were investigated in otitis media with effusion in children. Amounts of these antibodies were determined in middle ear effusions (MEEs) and in sera by enzyme-linked immunosorbent assay. At the same time the amounts of total IgG and IgA antibodies in MEEs in comparison with those in sera were analyzed by laser nephelometry. The amounts of specific and total IgG and IgA in the MEEs were higher than those in the sera. The MEEs/sera ratios of IgG and IgA antibodies in the children with mucoid effusions were higher than those in the children with serous effusions. The exception involved IgG determined by laser nephelometry. These data support the hypothesis that bacterial infections and the subsequent immune response contribute to the prolongation of otitis media with effusion in children, especially when effusions become mucoid.

Authors+Show Affiliations

Fujioka O
Department of Otolaryngology, Niigata University, School of Medicine, Japan.

MeSH

AdolescentAntibodies, BacterialBacterial Outer Membrane ProteinsChildChild, PreschoolEnzyme-Linked Immunosorbent AssayHaemophilus InfectionsHaemophilus influenzaeHumansImmunoglobulin AImmunoglobulin GInfantNephelometry and TurbidimetryOtitis Media with Effusion

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1768412

Citation

Fujioka, O. "The Immunological Role of the Outer Membrane Proteins of Non-typable Hemophilus Influenzae in Otitis Media With Effusion in Children." European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, vol. 248, no. 8, 1991, pp. 483-6.
Fujioka O. The immunological role of the outer membrane proteins of non-typable Hemophilus influenzae in otitis media with effusion in children. Eur Arch Otorhinolaryngol. 1991;248(8):483-6.
Fujioka, O. (1991). The immunological role of the outer membrane proteins of non-typable Hemophilus influenzae in otitis media with effusion in children. European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated With the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 248(8), 483-6.
Fujioka O. The Immunological Role of the Outer Membrane Proteins of Non-typable Hemophilus Influenzae in Otitis Media With Effusion in Children. Eur Arch Otorhinolaryngol. 1991;248(8):483-6. PubMed PMID: 1768412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The immunological role of the outer membrane proteins of non-typable Hemophilus influenzae in otitis media with effusion in children. A1 - Fujioka,O, PY - 1991/1/1/pubmed PY - 1991/1/1/medline PY - 1991/1/1/entrez SP - 483 EP - 6 JF - European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery JO - Eur Arch Otorhinolaryngol VL - 248 IS - 8 N2 - Specific IgG and IgA antibodies against the outer membrane proteins of non-typable Hemophilus influenzae were investigated in otitis media with effusion in children. Amounts of these antibodies were determined in middle ear effusions (MEEs) and in sera by enzyme-linked immunosorbent assay. At the same time the amounts of total IgG and IgA antibodies in MEEs in comparison with those in sera were analyzed by laser nephelometry. The amounts of specific and total IgG and IgA in the MEEs were higher than those in the sera. The MEEs/sera ratios of IgG and IgA antibodies in the children with mucoid effusions were higher than those in the children with serous effusions. The exception involved IgG determined by laser nephelometry. These data support the hypothesis that bacterial infections and the subsequent immune response contribute to the prolongation of otitis media with effusion in children, especially when effusions become mucoid. SN - 0937-4477 UR - https://www.unboundmedicine.com/medline/citation/1768412/The_immunological_role_of_the_outer_membrane_proteins_of_non_typable_Hemophilus_influenzae_in_otitis_media_with_effusion_in_children_ DB - PRIME DP - Unbound Medicine ER -