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Age-related changes in ocular aberrations with accommodation.
J Vis. 2007 May 30; 7(7):11.1-21.JV

Abstract

This study investigates the changes in aberrations with monocular accommodation as a function of age. Second-order and higher order wavefront aberrations and pupil size were measured as a function of accommodation demand over the range of 0-4 D in the right eyes of 47 normal subjects with ages between 17 and 56 years. Higher order ocular Zernike aberrations were analyzed for the natural pupil size in terms of their equivalent defocus and were also determined for fixed pupil diameters of 4.5 mm in the unaccommodated eyes and 2.5 mm in the accommodating eyes. With relaxed accommodation (0 D accommodation stimulus), the major change with age was in the value of C4(0), which increased in positive value over the age range studied, although the total higher order RMS wavefront aberration did not increase. When the data were analyzed for natural pupils, spherical aberration was again found to change systematically in the positive direction with age. The equivalent defocus of total higher order RMS error for natural pupils showed no significant correlation with age (p > .05). With active accommodation, spherical aberration was found to decrease and become negative as the accommodative response increased in the younger subjects (<40 years). Near-zero spherical aberration was found at accommodation levels of about 0.50 D in the youngest subjects (<20 years) and at around 2-3 D in subjects between 20 and 39 years. In the older subjects (>40 years), the spherical aberration showed only small changes, some of which were positive, within the limited amplitude of accommodation available. Other higher order aberrations and the RMS of higher order aberrations did not appear to change systematically with accommodation, except in the oldest subjects. The change with age in the relationship between aberration and accommodation is interpreted in terms of the changing gradients of refractive index and surface curvatures of the crystalline lens.

Authors+Show Affiliations

Faculty of Life Sciences, University of Manchester, Manchester, UK. Hema.Radhakrishnan@manchester.ac.ukNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17685807

Citation

Radhakrishnan, Hema, and W Neil Charman. "Age-related Changes in Ocular Aberrations With Accommodation." Journal of Vision, vol. 7, no. 7, 2007, pp. 11.1-21.
Radhakrishnan H, Charman WN. Age-related changes in ocular aberrations with accommodation. J Vis. 2007;7(7):11.1-21.
Radhakrishnan, H., & Charman, W. N. (2007). Age-related changes in ocular aberrations with accommodation. Journal of Vision, 7(7), 1-21.
Radhakrishnan H, Charman WN. Age-related Changes in Ocular Aberrations With Accommodation. J Vis. 2007 May 30;7(7):11.1-21. PubMed PMID: 17685807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Age-related changes in ocular aberrations with accommodation. AU - Radhakrishnan,Hema, AU - Charman,W Neil, Y1 - 2007/05/30/ PY - 2006/11/22/received PY - 2007/03/21/accepted PY - 2007/8/10/pubmed PY - 2007/9/19/medline PY - 2007/8/10/entrez SP - 11.1 EP - 21 JF - Journal of vision JO - J Vis VL - 7 IS - 7 N2 - This study investigates the changes in aberrations with monocular accommodation as a function of age. Second-order and higher order wavefront aberrations and pupil size were measured as a function of accommodation demand over the range of 0-4 D in the right eyes of 47 normal subjects with ages between 17 and 56 years. Higher order ocular Zernike aberrations were analyzed for the natural pupil size in terms of their equivalent defocus and were also determined for fixed pupil diameters of 4.5 mm in the unaccommodated eyes and 2.5 mm in the accommodating eyes. With relaxed accommodation (0 D accommodation stimulus), the major change with age was in the value of C4(0), which increased in positive value over the age range studied, although the total higher order RMS wavefront aberration did not increase. When the data were analyzed for natural pupils, spherical aberration was again found to change systematically in the positive direction with age. The equivalent defocus of total higher order RMS error for natural pupils showed no significant correlation with age (p > .05). With active accommodation, spherical aberration was found to decrease and become negative as the accommodative response increased in the younger subjects (<40 years). Near-zero spherical aberration was found at accommodation levels of about 0.50 D in the youngest subjects (<20 years) and at around 2-3 D in subjects between 20 and 39 years. In the older subjects (>40 years), the spherical aberration showed only small changes, some of which were positive, within the limited amplitude of accommodation available. Other higher order aberrations and the RMS of higher order aberrations did not appear to change systematically with accommodation, except in the oldest subjects. The change with age in the relationship between aberration and accommodation is interpreted in terms of the changing gradients of refractive index and surface curvatures of the crystalline lens. SN - 1534-7362 UR - https://www.unboundmedicine.com/medline/citation/17685807/Age_related_changes_in_ocular_aberrations_with_accommodation_ L2 - http://jov.arvojournals.org/article.aspx?doi=10.1167/7.7.11 DB - PRIME DP - Unbound Medicine ER -