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Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors.
Allergy. 2007 Sep; 62(9):1051-6.A

Abstract

BACKGROUND

Subjects with allergic rhinitis but no clinical evidence of asthma have greater bronchial hyperresponsiveness (BHR), and several factors have been implicated as its determinants. However, studies in young children are lacking. The aims of this study were to evaluate the prevalence of BHR in young children with allergic rhinitis and to investigate its risk factors.

METHODS

Methacholine bronchial challenges were performed in 4- to 6-year-old nonasthmatic children with allergic rhinitis (n = 83) and in healthy nonatopic controls (n = 32), using a modified auscultation method. The end-point was defined as the appearance of wheezing and/or oxygen desaturation. Subjects were considered to have BHR when they had end-point concentrations of methacholine <or=8 mg/mL. Clinical and laboratory data in allergic rhinitis patients and a history of allergic diseases in their parents were collected.

RESULTS

BHR was observed in 27 subjects with allergic rhinitis (32.5%) and three controls (9.4%). Among subjects with allergic rhinitis, serum total IgE, the number and pattern of skin-prick test responses, blood eosinophil markers, and parental history of allergic rhinitis and atopic dermatitis were not different between the BHR(+) and BHR(-) groups, whereas the persistent type of rhinitis and parental history of asthma were more frequent in the BHR(+) group than in the BHR(-) group. These associations remained significant in a multivariable logistic regression.

CONCLUSIONS

Young children with allergic rhinitis alone showed an increased prevalence of BHR. Both persistent type of rhinitis and parental history of asthma were significant and independent risk factors for BHR in these children.

Authors+Show Affiliations

Department of Pediatrics, Seoul National University Hospital, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17686108

Citation

Choi, S H., et al. "Bronchial Hyperresponsiveness in Young Children With Allergic Rhinitis and Its Risk Factors." Allergy, vol. 62, no. 9, 2007, pp. 1051-6.
Choi SH, Yoo Y, Yu J, et al. Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors. Allergy. 2007;62(9):1051-6.
Choi, S. H., Yoo, Y., Yu, J., Rhee, C. S., Min, Y. G., & Koh, Y. Y. (2007). Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors. Allergy, 62(9), 1051-6.
Choi SH, et al. Bronchial Hyperresponsiveness in Young Children With Allergic Rhinitis and Its Risk Factors. Allergy. 2007;62(9):1051-6. PubMed PMID: 17686108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bronchial hyperresponsiveness in young children with allergic rhinitis and its risk factors. AU - Choi,S H, AU - Yoo,Y, AU - Yu,J, AU - Rhee,C-S, AU - Min,Y-G, AU - Koh,Y Y, PY - 2007/8/10/pubmed PY - 2007/12/18/medline PY - 2007/8/10/entrez SP - 1051 EP - 6 JF - Allergy JO - Allergy VL - 62 IS - 9 N2 - BACKGROUND: Subjects with allergic rhinitis but no clinical evidence of asthma have greater bronchial hyperresponsiveness (BHR), and several factors have been implicated as its determinants. However, studies in young children are lacking. The aims of this study were to evaluate the prevalence of BHR in young children with allergic rhinitis and to investigate its risk factors. METHODS: Methacholine bronchial challenges were performed in 4- to 6-year-old nonasthmatic children with allergic rhinitis (n = 83) and in healthy nonatopic controls (n = 32), using a modified auscultation method. The end-point was defined as the appearance of wheezing and/or oxygen desaturation. Subjects were considered to have BHR when they had end-point concentrations of methacholine <or=8 mg/mL. Clinical and laboratory data in allergic rhinitis patients and a history of allergic diseases in their parents were collected. RESULTS: BHR was observed in 27 subjects with allergic rhinitis (32.5%) and three controls (9.4%). Among subjects with allergic rhinitis, serum total IgE, the number and pattern of skin-prick test responses, blood eosinophil markers, and parental history of allergic rhinitis and atopic dermatitis were not different between the BHR(+) and BHR(-) groups, whereas the persistent type of rhinitis and parental history of asthma were more frequent in the BHR(+) group than in the BHR(-) group. These associations remained significant in a multivariable logistic regression. CONCLUSIONS: Young children with allergic rhinitis alone showed an increased prevalence of BHR. Both persistent type of rhinitis and parental history of asthma were significant and independent risk factors for BHR in these children. SN - 0105-4538 UR - https://www.unboundmedicine.com/medline/citation/17686108/Bronchial_hyperresponsiveness_in_young_children_with_allergic_rhinitis_and_its_risk_factors_ L2 - https://doi.org/10.1111/j.1398-9995.2007.01403.x DB - PRIME DP - Unbound Medicine ER -