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Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy.
J Ethnopharmacol. 2007 Sep 05; 113(2):346-53.JE

Abstract

The aim of this study was to investigate the anti-inflammatory effects and the mechanism of action of the aqueous extracts obtained from rhizomes, leaves and inflorescences of Solidago chilensis in the mouse model of pleurisy. The extracts were prepared by infusion and were lyophilized.

RESULTS

The aqueous extracts of rhizomes, leaves or inflorescences inhibited leukocytes, neutrophils and exudation (P<0.05) in the inflammation induced by carrageenan. The rhizomes aqueous extract, butanolic and aqueous residual fractions inhibited leukocytes, neutrophils, myeloperoxidase, adenosine-deaminase, and tumor necrosis factor alpha levels in the inflammation induced by carrageenan (P<0.05). The rhizome aqueous extract and butanolic fraction also inhibited exudation, nitric oxide, and interleukin-1 beta levels (P<0.05). The rhizomes aqueous extract and its two derived fractions reduced leukocytes and mononuclears in the pleurisy induced by bradykinin, histamine, or substance P (P<0.05) and neutrophils in the pleurisy induced by histamine or substance P (P<0.05). Only aqueous residual fraction inhibited neutrophils induced by bradykinin (P<0.05).

CONCLUSION

Solidago chilensis aqueous extracts from leaves, inflorescences and rhizomes demonstrated an important anti-inflammatory effect, inhibiting cells in the inflammation caused by carrageenan. In addition, the rhizomes aqueous extract and its derived fractions also decreased pro-inflammatory mediators release into the site of the inflammatory process. The rhizomes aqueous extract and the butanolic fraction showed more evident anti-inflammatory actions.

Authors+Show Affiliations

Department of Clinical Analysis, Centre of Health Sciences, Federal University of Santa Catarina, Campus Universitário-Trindade, 88040-970 Florianópolis, SC, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17686594

Citation

Goulart, Stella, et al. "Anti-inflammatory Evaluation of Solidago Chilensis Meyen in a Murine Model of Pleurisy." Journal of Ethnopharmacology, vol. 113, no. 2, 2007, pp. 346-53.
Goulart S, Moritz MI, Lang KL, et al. Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy. J Ethnopharmacol. 2007;113(2):346-53.
Goulart, S., Moritz, M. I., Lang, K. L., Liz, R., Schenkel, E. P., & Fröde, T. S. (2007). Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy. Journal of Ethnopharmacology, 113(2), 346-53.
Goulart S, et al. Anti-inflammatory Evaluation of Solidago Chilensis Meyen in a Murine Model of Pleurisy. J Ethnopharmacol. 2007 Sep 5;113(2):346-53. PubMed PMID: 17686594.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-inflammatory evaluation of Solidago chilensis Meyen in a murine model of pleurisy. AU - Goulart,Stella, AU - Moritz,Maria Izabel Goularte, AU - Lang,Karen Luise, AU - Liz,Rafael, AU - Schenkel,Eloir Paulo, AU - Fröde,Tânia Silvia, Y1 - 2007/07/07/ PY - 2007/06/25/received PY - 2007/07/01/accepted PY - 2007/8/10/pubmed PY - 2007/12/28/medline PY - 2007/8/10/entrez SP - 346 EP - 53 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 113 IS - 2 N2 - UNLABELLED: The aim of this study was to investigate the anti-inflammatory effects and the mechanism of action of the aqueous extracts obtained from rhizomes, leaves and inflorescences of Solidago chilensis in the mouse model of pleurisy. The extracts were prepared by infusion and were lyophilized. RESULTS: The aqueous extracts of rhizomes, leaves or inflorescences inhibited leukocytes, neutrophils and exudation (P<0.05) in the inflammation induced by carrageenan. The rhizomes aqueous extract, butanolic and aqueous residual fractions inhibited leukocytes, neutrophils, myeloperoxidase, adenosine-deaminase, and tumor necrosis factor alpha levels in the inflammation induced by carrageenan (P<0.05). The rhizome aqueous extract and butanolic fraction also inhibited exudation, nitric oxide, and interleukin-1 beta levels (P<0.05). The rhizomes aqueous extract and its two derived fractions reduced leukocytes and mononuclears in the pleurisy induced by bradykinin, histamine, or substance P (P<0.05) and neutrophils in the pleurisy induced by histamine or substance P (P<0.05). Only aqueous residual fraction inhibited neutrophils induced by bradykinin (P<0.05). CONCLUSION: Solidago chilensis aqueous extracts from leaves, inflorescences and rhizomes demonstrated an important anti-inflammatory effect, inhibiting cells in the inflammation caused by carrageenan. In addition, the rhizomes aqueous extract and its derived fractions also decreased pro-inflammatory mediators release into the site of the inflammatory process. The rhizomes aqueous extract and the butanolic fraction showed more evident anti-inflammatory actions. SN - 0378-8741 UR - https://www.unboundmedicine.com/medline/citation/17686594/Anti_inflammatory_evaluation_of_Solidago_chilensis_Meyen_in_a_murine_model_of_pleurisy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(07)00324-8 DB - PRIME DP - Unbound Medicine ER -