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Surgical outcomes of the mass-forming plus periductal infiltrating types of intrahepatic cholangiocarcinoma: a comparative study with the typical mass-forming type of intrahepatic cholangiocarcinoma.
World J Surg. 2007 Oct; 31(10):2016-22.WJ

Abstract

BACKGROUND

The purpose of this study was to clarify the clinicopathologic characteristics and surgical outcomes of patients with the mass-forming (MF) plus periductal infiltrating (PI) type of intrahepatic cholangiocellular carcinoma (ICC).

METHODS

Between January 1, 1998, and December 31, 2004, a total of 94 patients with ICC underwent macroscopic curative resection, and the macroscopic type of the tumors was assessed prospectively. Among the 74 patients with the MF type (n = 46) and the MF plus PI type (n = 28) of ICC, multivariate analysis was conducted to identify the potential prognostic factors. The clinicopathologic data of the two groups were compared.

RESULTS

The results revealed two independent prognostic factors: presence/absence of intrahepatic metastasis and the macroscopic type of the tumor. ICCs categorized macroscopically as the MF plus PI type were significantly associated with jaundice (p < 0.001), bile duct invasion (p < 0.001), portal vein invasion (p = 0.025), lymph node involvement (p = 0.017), and positive surgical margin (p = 0.038).

CONCLUSION

Identification of the macroscopic type of the tumor is useful for predicting survival after hepatectomy in patients with ICC. The MF plus PI type of ICC appears to have a more unfavorable prognosis, even after radical surgery, than the MF type of ICC.

Authors+Show Affiliations

Department of Hepatobiliary and Pancreatic Surgery Division, National Cancer Center Hospital, Tokyo, Japan. kshimada@ncc.go.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17687597

Citation

Shimada, Kazuaki, et al. "Surgical Outcomes of the Mass-forming Plus Periductal Infiltrating Types of Intrahepatic Cholangiocarcinoma: a Comparative Study With the Typical Mass-forming Type of Intrahepatic Cholangiocarcinoma." World Journal of Surgery, vol. 31, no. 10, 2007, pp. 2016-22.
Shimada K, Sano T, Sakamoto Y, et al. Surgical outcomes of the mass-forming plus periductal infiltrating types of intrahepatic cholangiocarcinoma: a comparative study with the typical mass-forming type of intrahepatic cholangiocarcinoma. World J Surg. 2007;31(10):2016-22.
Shimada, K., Sano, T., Sakamoto, Y., Esaki, M., Kosuge, T., & Ojima, H. (2007). Surgical outcomes of the mass-forming plus periductal infiltrating types of intrahepatic cholangiocarcinoma: a comparative study with the typical mass-forming type of intrahepatic cholangiocarcinoma. World Journal of Surgery, 31(10), 2016-22.
Shimada K, et al. Surgical Outcomes of the Mass-forming Plus Periductal Infiltrating Types of Intrahepatic Cholangiocarcinoma: a Comparative Study With the Typical Mass-forming Type of Intrahepatic Cholangiocarcinoma. World J Surg. 2007;31(10):2016-22. PubMed PMID: 17687597.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Surgical outcomes of the mass-forming plus periductal infiltrating types of intrahepatic cholangiocarcinoma: a comparative study with the typical mass-forming type of intrahepatic cholangiocarcinoma. AU - Shimada,Kazuaki, AU - Sano,Tsuyoshi, AU - Sakamoto,Yoshihiro, AU - Esaki,Minoru, AU - Kosuge,Tomoo, AU - Ojima,Hidenori, PY - 2007/8/10/pubmed PY - 2007/12/21/medline PY - 2007/8/10/entrez SP - 2016 EP - 22 JF - World journal of surgery JO - World J Surg VL - 31 IS - 10 N2 - BACKGROUND: The purpose of this study was to clarify the clinicopathologic characteristics and surgical outcomes of patients with the mass-forming (MF) plus periductal infiltrating (PI) type of intrahepatic cholangiocellular carcinoma (ICC). METHODS: Between January 1, 1998, and December 31, 2004, a total of 94 patients with ICC underwent macroscopic curative resection, and the macroscopic type of the tumors was assessed prospectively. Among the 74 patients with the MF type (n = 46) and the MF plus PI type (n = 28) of ICC, multivariate analysis was conducted to identify the potential prognostic factors. The clinicopathologic data of the two groups were compared. RESULTS: The results revealed two independent prognostic factors: presence/absence of intrahepatic metastasis and the macroscopic type of the tumor. ICCs categorized macroscopically as the MF plus PI type were significantly associated with jaundice (p < 0.001), bile duct invasion (p < 0.001), portal vein invasion (p = 0.025), lymph node involvement (p = 0.017), and positive surgical margin (p = 0.038). CONCLUSION: Identification of the macroscopic type of the tumor is useful for predicting survival after hepatectomy in patients with ICC. The MF plus PI type of ICC appears to have a more unfavorable prognosis, even after radical surgery, than the MF type of ICC. SN - 0364-2313 UR - https://www.unboundmedicine.com/medline/citation/17687597/Surgical_outcomes_of_the_mass_forming_plus_periductal_infiltrating_types_of_intrahepatic_cholangiocarcinoma:_a_comparative_study_with_the_typical_mass_forming_type_of_intrahepatic_cholangiocarcinoma_ L2 - https://dx.doi.org/10.1007/s00268-007-9194-0 DB - PRIME DP - Unbound Medicine ER -