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Effect of tegaserod on colonic transit time in male patients with constipation-predominant irritable bowel syndrome.
J Gastroenterol Hepatol 2007; 22(8):1183-9JG

Abstract

BACKGROUND AND AIMS

Tegaserod is approved for the treatment of constipation-predominant irritable bowel syndrome (C-IBS) in females. The aim of this study was to evaluate the effect of tegaserod on colonic transit time (CTT) and symptoms in male patients with C-IBS.

METHODS

Forty-four males with C-IBS (Rome II) were enrolled. After a baseline washout period of 2 weeks, 40 patients were randomized to 6 mg twice daily of tegaserod or placebo for 12 weeks. Daily bowel habits and weekly satisfactory relief of symptoms were recorded. Total and segmental CTT were measured using radiopaque markers at baseline and after treatment.

RESULTS

The mean +/- SD for the total colonic, right colonic, left colonic and rectosigmoid transit time (in hours) were 18.96 +/- 3.92, 7.74 +/- 1.55, 5.64 +/- 1.51 and 5.58 +/- 2.2 in the tegaserod group compared to 22.47 +/- 3.73, 9.69 +/- 2.33, 6.6 +/- 1.32 and 6.18 +/- 2.22 in the placebo group at the end of 12 weeks. There was a statistically significant difference in the total, right and left CTT in the tegaserod group (P < 0.05) at the end of treatment. Global satisfactory relief at the end of 12 weeks was 75% in the tegaserod group and 50% in the placebo group (P > 0.05). Greater stool frequency occurred in the tegaserod group (P > 0.05). There was a significant decrease in the stool consistency at the end of 12 weeks in patients treated with tegaserod (P < 0.05).

CONCLUSIONS

Tegaserod causes significant acceleration of CTT in male patients with C-IBS. Although there was a trend towards improvement in bowel symptoms in the treated group, this effect was not statistically significant.

Authors+Show Affiliations

Department of Gastroenterology, Calicut Medical College, Calicut, Kerala, India. dr_harishk@yahoo.co.inNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

17688659

Citation

Harish, Kareem, et al. "Effect of Tegaserod On Colonic Transit Time in Male Patients With Constipation-predominant Irritable Bowel Syndrome." Journal of Gastroenterology and Hepatology, vol. 22, no. 8, 2007, pp. 1183-9.
Harish K, Hazeena K, Thomas V, et al. Effect of tegaserod on colonic transit time in male patients with constipation-predominant irritable bowel syndrome. J Gastroenterol Hepatol. 2007;22(8):1183-9.
Harish, K., Hazeena, K., Thomas, V., Kumar, S., Jose, T., & Narayanan, P. (2007). Effect of tegaserod on colonic transit time in male patients with constipation-predominant irritable bowel syndrome. Journal of Gastroenterology and Hepatology, 22(8), pp. 1183-9.
Harish K, et al. Effect of Tegaserod On Colonic Transit Time in Male Patients With Constipation-predominant Irritable Bowel Syndrome. J Gastroenterol Hepatol. 2007;22(8):1183-9. PubMed PMID: 17688659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of tegaserod on colonic transit time in male patients with constipation-predominant irritable bowel syndrome. AU - Harish,Kareem, AU - Hazeena,Kizhekkan, AU - Thomas,Varghese, AU - Kumar,Sunil, AU - Jose,Tony, AU - Narayanan,Puthiyaveetil, PY - 2007/8/11/pubmed PY - 2007/10/17/medline PY - 2007/8/11/entrez SP - 1183 EP - 9 JF - Journal of gastroenterology and hepatology JO - J. Gastroenterol. Hepatol. VL - 22 IS - 8 N2 - BACKGROUND AND AIMS: Tegaserod is approved for the treatment of constipation-predominant irritable bowel syndrome (C-IBS) in females. The aim of this study was to evaluate the effect of tegaserod on colonic transit time (CTT) and symptoms in male patients with C-IBS. METHODS: Forty-four males with C-IBS (Rome II) were enrolled. After a baseline washout period of 2 weeks, 40 patients were randomized to 6 mg twice daily of tegaserod or placebo for 12 weeks. Daily bowel habits and weekly satisfactory relief of symptoms were recorded. Total and segmental CTT were measured using radiopaque markers at baseline and after treatment. RESULTS: The mean +/- SD for the total colonic, right colonic, left colonic and rectosigmoid transit time (in hours) were 18.96 +/- 3.92, 7.74 +/- 1.55, 5.64 +/- 1.51 and 5.58 +/- 2.2 in the tegaserod group compared to 22.47 +/- 3.73, 9.69 +/- 2.33, 6.6 +/- 1.32 and 6.18 +/- 2.22 in the placebo group at the end of 12 weeks. There was a statistically significant difference in the total, right and left CTT in the tegaserod group (P < 0.05) at the end of treatment. Global satisfactory relief at the end of 12 weeks was 75% in the tegaserod group and 50% in the placebo group (P > 0.05). Greater stool frequency occurred in the tegaserod group (P > 0.05). There was a significant decrease in the stool consistency at the end of 12 weeks in patients treated with tegaserod (P < 0.05). CONCLUSIONS: Tegaserod causes significant acceleration of CTT in male patients with C-IBS. Although there was a trend towards improvement in bowel symptoms in the treated group, this effect was not statistically significant. SN - 0815-9319 UR - https://www.unboundmedicine.com/medline/citation/17688659/Effect_of_tegaserod_on_colonic_transit_time_in_male_patients_with_constipation_predominant_irritable_bowel_syndrome_ L2 - https://doi.org/10.1111/j.1440-1746.2006.04543.x DB - PRIME DP - Unbound Medicine ER -