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Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression.
Int J Pharm. 2008 Jan 04; 346(1-2):17-24.IJ

Abstract

A model that describes the relationship between roller-compaction conditions and tablet strength is proposed. The model assumes that compaction is cumulative during roller compaction and subsequent granule compaction, and compact strength (ribbon and tablet) is generated irreversibly as if strength is controlled by plastic deformation of primary particles only. Roller-compaction is treated as a compaction step where the macroscopic ribbon strength is subsequently destroyed in milling. This loss in strength is irreversible and tablets compressed from the resulting granulation are weaker than those compressed by direct compression at the same compression force. Roller-compacted ribbons were produced at a range of roll forces for three formulations and subsequently milled and compacted into tablets. Once the total compaction history is taken in account, the compaction behavior of the uncompacted blends and the roller-compacted granules ultimately follow a single master compaction curve--a unified compaction curve (UCC). The model successfully described the compaction behavior of DC grade starch and formulations of lactose monohydrate with 50% or more microcrystalline cellulose, and may be more generally applicable to systems containing significant proportions of any plastically deforming material, including MCC and starch.

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Authors+Show Affiliations

Farber L
Merck and Co. Inc., West Point, PA, USA. leon_farber@merck.com
Hapgood KP
No affiliation info available
Michaels JN
No affiliation info available
Fu XY
No affiliation info available
Meyer R
No affiliation info available
Johnson MA
No affiliation info available
Li F
No affiliation info available

MeSH

CelluloseDrug CompoundingLactoseModels, ChemicalTabletsTensile Strength

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17689211

Citation

Farber, Leon, et al. "Unified Compaction Curve Model for Tensile Strength of Tablets Made By Roller Compaction and Direct Compression." International Journal of Pharmaceutics, vol. 346, no. 1-2, 2008, pp. 17-24.
Farber L, Hapgood KP, Michaels JN, et al. Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression. Int J Pharm. 2008;346(1-2):17-24.
Farber, L., Hapgood, K. P., Michaels, J. N., Fu, X. Y., Meyer, R., Johnson, M. A., & Li, F. (2008). Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression. International Journal of Pharmaceutics, 346(1-2), 17-24.
Farber L, et al. Unified Compaction Curve Model for Tensile Strength of Tablets Made By Roller Compaction and Direct Compression. Int J Pharm. 2008 Jan 4;346(1-2):17-24. PubMed PMID: 17689211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Unified compaction curve model for tensile strength of tablets made by roller compaction and direct compression. AU - Farber,Leon, AU - Hapgood,Karen P, AU - Michaels,James N, AU - Fu,Xi-Young, AU - Meyer,Robert, AU - Johnson,Mary-Ann, AU - Li,Feng, Y1 - 2007/06/22/ PY - 2007/02/01/received PY - 2007/05/31/revised PY - 2007/06/01/accepted PY - 2007/8/11/pubmed PY - 2008/2/22/medline PY - 2007/8/11/entrez SP - 17 EP - 24 JF - International journal of pharmaceutics JO - Int J Pharm VL - 346 IS - 1-2 N2 - A model that describes the relationship between roller-compaction conditions and tablet strength is proposed. The model assumes that compaction is cumulative during roller compaction and subsequent granule compaction, and compact strength (ribbon and tablet) is generated irreversibly as if strength is controlled by plastic deformation of primary particles only. Roller-compaction is treated as a compaction step where the macroscopic ribbon strength is subsequently destroyed in milling. This loss in strength is irreversible and tablets compressed from the resulting granulation are weaker than those compressed by direct compression at the same compression force. Roller-compacted ribbons were produced at a range of roll forces for three formulations and subsequently milled and compacted into tablets. Once the total compaction history is taken in account, the compaction behavior of the uncompacted blends and the roller-compacted granules ultimately follow a single master compaction curve--a unified compaction curve (UCC). The model successfully described the compaction behavior of DC grade starch and formulations of lactose monohydrate with 50% or more microcrystalline cellulose, and may be more generally applicable to systems containing significant proportions of any plastically deforming material, including MCC and starch. SN - 0378-5173 UR - https://www.unboundmedicine.com/medline/citation/17689211/Unified_compaction_curve_model_for_tensile_strength_of_tablets_made_by_roller_compaction_and_direct_compression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(07)00494-2 DB - PRIME DP - Unbound Medicine ER -