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The presence of apolipoprotein epsilon4 and epsilon2 alleles augments the risk of coronary artery disease in type 2 diabetic patients.
Clin Biochem 2007; 40(15):1150-6CB

Abstract

OBJECTIVE

It has been suggested that there is a relationship between apolipoprotein E polymorphism and the severity of coronary artery disease in type II diabetes mellitus (T2DM). The current study specifically aimed to examine whether APOE polymorphism in association with serum lipids-lipoproteins level is a risk factor for developing coronary artery disease (CAD) in diabetic patients living in western of Iran.

METHODS

The APOE genotypes were detected by PCR-RFLP in 152 angiographically documented diabetic CAD patients, 262 non-diabetic (ND) individuals with CAD and 300 unrelated controls (normal coronary artery cases without diabetes) and serum lipid level was measured enzymatically.

RESULTS

The APOE-epsilon4 and epsilon2 allele frequencies were significantly higher in the CAD/T2DM and CAD/ND patients than in the control group (p<0.001). Our study demonstrated a significant association between APOE polymorphism and the level of plasma lipids with CAD/T2DM (p=0.001) and CAD/ND (p=0.026) patients. The CAD subjects with T2DM and ND patients carrying APOE-epsilon4 allele had lower plasma HDL-C level (p<0.001), (p=0.008) but had higher plasma LDL-C (p=0.01), total cholesterol (p=0.002), (p=0.03) and TG (p<0.001), (p=0.042) than that of the APOE-epsilon3 carriers, respectively. However, carriers of APOE-epsilon2 had significantly higher levels of plasma TG only. OR of APOE-epsilon4 and epsilon2 alleles in CAD/T2DM and CAD/ND patients were found to be 2.98 (p=0.001),1.86 (p=0.001), 2 (p=0.001), and 1.65 (p=0.001), respectively.

CONCLUSIONS

The major finding of the present case-control study is that T2DM patients carrying APOE-epsilon2 and epsilon4 alleles have a higher risk of developing CAD than ND patients in the western population of Iran, with APOE-epsilon4 being more closely associated with CAD than the APOE-epsilon2 allele. These results indicated that carriers of APOE-epsilon4 allele have a distinct plasma lipids profile and carrier of this allele with low levels of HDL-C and with high levels of LDL-C may be susceptible to CAD and myocardial infarction specially in diabetic patients. This suggests that a therapeutic modality should be considered for these patients.

Authors+Show Affiliations

Department of Clinical Biochemistry, Kermanshah University of Medical Sciences, Kermanshah, Iran. vaisira@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17689519

Citation

Vaisi-Raygani, Asad, et al. "The Presence of Apolipoprotein Epsilon4 and Epsilon2 Alleles Augments the Risk of Coronary Artery Disease in Type 2 Diabetic Patients." Clinical Biochemistry, vol. 40, no. 15, 2007, pp. 1150-6.
Vaisi-Raygani A, Rahimi Z, Nomani H, et al. The presence of apolipoprotein epsilon4 and epsilon2 alleles augments the risk of coronary artery disease in type 2 diabetic patients. Clin Biochem. 2007;40(15):1150-6.
Vaisi-Raygani, A., Rahimi, Z., Nomani, H., Tavilani, H., & Pourmotabbed, T. (2007). The presence of apolipoprotein epsilon4 and epsilon2 alleles augments the risk of coronary artery disease in type 2 diabetic patients. Clinical Biochemistry, 40(15), pp. 1150-6.
Vaisi-Raygani A, et al. The Presence of Apolipoprotein Epsilon4 and Epsilon2 Alleles Augments the Risk of Coronary Artery Disease in Type 2 Diabetic Patients. Clin Biochem. 2007;40(15):1150-6. PubMed PMID: 17689519.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The presence of apolipoprotein epsilon4 and epsilon2 alleles augments the risk of coronary artery disease in type 2 diabetic patients. AU - Vaisi-Raygani,Asad, AU - Rahimi,Zohreh, AU - Nomani,Hamid, AU - Tavilani,Haidar, AU - Pourmotabbed,Tayebeh, Y1 - 2007/07/06/ PY - 2007/03/15/received PY - 2007/05/23/revised PY - 2007/06/09/accepted PY - 2007/8/11/pubmed PY - 2007/12/20/medline PY - 2007/8/11/entrez SP - 1150 EP - 6 JF - Clinical biochemistry JO - Clin. Biochem. VL - 40 IS - 15 N2 - OBJECTIVE: It has been suggested that there is a relationship between apolipoprotein E polymorphism and the severity of coronary artery disease in type II diabetes mellitus (T2DM). The current study specifically aimed to examine whether APOE polymorphism in association with serum lipids-lipoproteins level is a risk factor for developing coronary artery disease (CAD) in diabetic patients living in western of Iran. METHODS: The APOE genotypes were detected by PCR-RFLP in 152 angiographically documented diabetic CAD patients, 262 non-diabetic (ND) individuals with CAD and 300 unrelated controls (normal coronary artery cases without diabetes) and serum lipid level was measured enzymatically. RESULTS: The APOE-epsilon4 and epsilon2 allele frequencies were significantly higher in the CAD/T2DM and CAD/ND patients than in the control group (p<0.001). Our study demonstrated a significant association between APOE polymorphism and the level of plasma lipids with CAD/T2DM (p=0.001) and CAD/ND (p=0.026) patients. The CAD subjects with T2DM and ND patients carrying APOE-epsilon4 allele had lower plasma HDL-C level (p<0.001), (p=0.008) but had higher plasma LDL-C (p=0.01), total cholesterol (p=0.002), (p=0.03) and TG (p<0.001), (p=0.042) than that of the APOE-epsilon3 carriers, respectively. However, carriers of APOE-epsilon2 had significantly higher levels of plasma TG only. OR of APOE-epsilon4 and epsilon2 alleles in CAD/T2DM and CAD/ND patients were found to be 2.98 (p=0.001),1.86 (p=0.001), 2 (p=0.001), and 1.65 (p=0.001), respectively. CONCLUSIONS: The major finding of the present case-control study is that T2DM patients carrying APOE-epsilon2 and epsilon4 alleles have a higher risk of developing CAD than ND patients in the western population of Iran, with APOE-epsilon4 being more closely associated with CAD than the APOE-epsilon2 allele. These results indicated that carriers of APOE-epsilon4 allele have a distinct plasma lipids profile and carrier of this allele with low levels of HDL-C and with high levels of LDL-C may be susceptible to CAD and myocardial infarction specially in diabetic patients. This suggests that a therapeutic modality should be considered for these patients. SN - 0009-9120 UR - https://www.unboundmedicine.com/medline/citation/17689519/The_presence_of_apolipoprotein_epsilon4_and_epsilon2_alleles_augments_the_risk_of_coronary_artery_disease_in_type_2_diabetic_patients_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0009-9120(07)00259-7 DB - PRIME DP - Unbound Medicine ER -