Tags

Type your tag names separated by a space and hit enter

Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat.

Abstract

Asian ginseng (Panax ginseng) and its close relative North American ginseng (Panax quinquefolius) are perennial aromatic herbs that are widely used in Oriental medicine and have been acclaimed to have various health benefits including diabetes treatment. In this study, we compared the effects of a diet containing rosiglitazone to a diet containing ginseng (Panax quinquefolius) in male Zucker diabetic fatty (ZDF) rats. Animals were assigned to one of three diets: control, rosiglitazone (0.1 g/1 kg diet), or ginseng (10 g/1 kg diet). During the 11-week study, body weight, food intake, organ weight, blood glucose, plasma cholesterol, and plasma triglyceride levels were evaluated. Animals treated with rosiglitazone or ginseng exhibited increased body weight (p<0.05) and decreased kidney weight (p<0.05) compared to control animals. The rosiglitazone group demonstrated decreased food intake and plasma triglyceride levels versus the other groups (p<0.05). The ginseng group revealed decreased cholesterol levels relative to the control group (p<0.05). Furthermore, ginseng and rosiglitazone had marked effects on the expression of genes involved in PPAR actions and triglyceride metabolism compared to controls. In conclusion, ginseng modified the diabetic phenotype and genes associated with diabetes in the male ZDF rat. These data are encouraging, and warrant further research to determine the therapeutic value of this medicinal herb in treating human diabetes.

Links

  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Department of Animal Science, Food and Nutrition, Southern Illinois University, Carbondale, IL 62901-4317, USA. banz@siu.edu

    , , , , , ,

    Source

    MeSH

    Administration, Oral
    Animals
    Blood Glucose
    Cholesterol
    DNA Primers
    Diabetes Mellitus
    Diet
    Gene Expression Regulation
    Hypoglycemic Agents
    Male
    PPAR gamma
    Panax
    Phytotherapy
    Plant Extracts
    Polymerase Chain Reaction
    Rats
    Rats, Zucker
    Rosiglitazone
    Thiazolidinediones
    Triglycerides

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    17689944

    Citation

    Banz, William J., et al. "Ginseng Modifies the Diabetic Phenotype and Genes Associated With Diabetes in the Male ZDF Rat." Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, vol. 14, no. 10, 2007, pp. 681-9.
    Banz WJ, Iqbal MJ, Bollaert M, et al. Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat. Phytomedicine. 2007;14(10):681-9.
    Banz, W. J., Iqbal, M. J., Bollaert, M., Chickris, N., James, B., Higginbotham, D. A., ... Murphy, L. (2007). Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology, 14(10), pp. 681-9.
    Banz WJ, et al. Ginseng Modifies the Diabetic Phenotype and Genes Associated With Diabetes in the Male ZDF Rat. Phytomedicine. 2007;14(10):681-9. PubMed PMID: 17689944.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Ginseng modifies the diabetic phenotype and genes associated with diabetes in the male ZDF rat. AU - Banz,William J, AU - Iqbal,M J, AU - Bollaert,Michael, AU - Chickris,Nicole, AU - James,Bryce, AU - Higginbotham,D Allan, AU - Peterson,Richard, AU - Murphy,Laura, Y1 - 2007/08/08/ PY - 2007/04/05/received PY - 2007/06/18/accepted PY - 2007/8/11/pubmed PY - 2007/12/6/medline PY - 2007/8/11/entrez SP - 681 EP - 9 JF - Phytomedicine : international journal of phytotherapy and phytopharmacology JO - Phytomedicine VL - 14 IS - 10 N2 - Asian ginseng (Panax ginseng) and its close relative North American ginseng (Panax quinquefolius) are perennial aromatic herbs that are widely used in Oriental medicine and have been acclaimed to have various health benefits including diabetes treatment. In this study, we compared the effects of a diet containing rosiglitazone to a diet containing ginseng (Panax quinquefolius) in male Zucker diabetic fatty (ZDF) rats. Animals were assigned to one of three diets: control, rosiglitazone (0.1 g/1 kg diet), or ginseng (10 g/1 kg diet). During the 11-week study, body weight, food intake, organ weight, blood glucose, plasma cholesterol, and plasma triglyceride levels were evaluated. Animals treated with rosiglitazone or ginseng exhibited increased body weight (p<0.05) and decreased kidney weight (p<0.05) compared to control animals. The rosiglitazone group demonstrated decreased food intake and plasma triglyceride levels versus the other groups (p<0.05). The ginseng group revealed decreased cholesterol levels relative to the control group (p<0.05). Furthermore, ginseng and rosiglitazone had marked effects on the expression of genes involved in PPAR actions and triglyceride metabolism compared to controls. In conclusion, ginseng modified the diabetic phenotype and genes associated with diabetes in the male ZDF rat. These data are encouraging, and warrant further research to determine the therapeutic value of this medicinal herb in treating human diabetes. SN - 0944-7113 UR - https://www.unboundmedicine.com/medline/citation/17689944/Ginseng_modifies_the_diabetic_phenotype_and_genes_associated_with_diabetes_in_the_male_ZDF_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0944-7113(07)00107-9 DB - PRIME DP - Unbound Medicine ER -