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A prospective study of fruits, vegetables, and risk of endometrial cancer.
Am J Epidemiol 2007; 166(8):902-11AJ

Abstract

Case-control studies support a lower risk of endometrial cancer associated with greater vegetable consumption but not fruit consumption. One prospective study suggested an inverse association with fruits and vegetables combined. The authors examined associations for vegetables and fruits separately among women in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. After exclusions, 41,400 postmenopausal women completed a questionnaire on diet, lifestyle, and medical history at baseline in 1992-1993. Information on diet was updated in 1999; historical dietary information from 1982 was also available. The authors identified 435 eligible cases of endometrial cancer through 2003. In multivariate models, neither fruit consumption (top quintile vs. bottom: rate ratio (RR) = 1.24, 95% confidence interval (CI): 0.90, 1.70; p-trend = 0.30) nor vegetable consumption (RR = 1.21, 95% CI: 0.89, 1.65; p-trend = 0.24) at baseline was associated with risk. Results were similar when diet was cumulatively updated. Only among women who had never used hormone replacement therapy was the risk of endometrial cancer lower in the highest (vs. lowest) tertile of fruit (RR = 0.75, 95% CI: 0.52, 1.07; p-interaction = 0.03, p-trend = 0.11) or vegetable (RR = 0.80, 95% CI: 0.57, 1.13; p-interaction = 0.01, p-trend = 0.29) consumption. This prospective study does not support an association between vegetable or fruit consumption and endometrial cancer.

Authors+Show Affiliations

Epidemiology and Surveillance Research Department, American Cancer Society, Atlanta, GA 30303-1002, USA. marji-mccullough@cancer.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17690222

Citation

McCullough, Marjorie L., et al. "A Prospective Study of Fruits, Vegetables, and Risk of Endometrial Cancer." American Journal of Epidemiology, vol. 166, no. 8, 2007, pp. 902-11.
McCullough ML, Bandera EV, Patel R, et al. A prospective study of fruits, vegetables, and risk of endometrial cancer. Am J Epidemiol. 2007;166(8):902-11.
McCullough, M. L., Bandera, E. V., Patel, R., Patel, A. V., Gansler, T., Kushi, L. H., ... Calle, E. E. (2007). A prospective study of fruits, vegetables, and risk of endometrial cancer. American Journal of Epidemiology, 166(8), pp. 902-11.
McCullough ML, et al. A Prospective Study of Fruits, Vegetables, and Risk of Endometrial Cancer. Am J Epidemiol. 2007 Oct 15;166(8):902-11. PubMed PMID: 17690222.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of fruits, vegetables, and risk of endometrial cancer. AU - McCullough,Marjorie L, AU - Bandera,Elisa V, AU - Patel,Roshni, AU - Patel,Alpa V, AU - Gansler,Ted, AU - Kushi,Lawrence H, AU - Thun,Michael J, AU - Calle,Eugenia E, Y1 - 2007/08/09/ PY - 2007/8/11/pubmed PY - 2007/11/10/medline PY - 2007/8/11/entrez SP - 902 EP - 11 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 166 IS - 8 N2 - Case-control studies support a lower risk of endometrial cancer associated with greater vegetable consumption but not fruit consumption. One prospective study suggested an inverse association with fruits and vegetables combined. The authors examined associations for vegetables and fruits separately among women in the American Cancer Society's Cancer Prevention Study II Nutrition Cohort. After exclusions, 41,400 postmenopausal women completed a questionnaire on diet, lifestyle, and medical history at baseline in 1992-1993. Information on diet was updated in 1999; historical dietary information from 1982 was also available. The authors identified 435 eligible cases of endometrial cancer through 2003. In multivariate models, neither fruit consumption (top quintile vs. bottom: rate ratio (RR) = 1.24, 95% confidence interval (CI): 0.90, 1.70; p-trend = 0.30) nor vegetable consumption (RR = 1.21, 95% CI: 0.89, 1.65; p-trend = 0.24) at baseline was associated with risk. Results were similar when diet was cumulatively updated. Only among women who had never used hormone replacement therapy was the risk of endometrial cancer lower in the highest (vs. lowest) tertile of fruit (RR = 0.75, 95% CI: 0.52, 1.07; p-interaction = 0.03, p-trend = 0.11) or vegetable (RR = 0.80, 95% CI: 0.57, 1.13; p-interaction = 0.01, p-trend = 0.29) consumption. This prospective study does not support an association between vegetable or fruit consumption and endometrial cancer. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/17690222/full_citation L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwm156 DB - PRIME DP - Unbound Medicine ER -