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Voice outcomes of polyacrylamide hydrogel injection laryngoplasty.
Laryngoscope. 2007 Oct; 117(10):1871-5.L

Abstract

OBJECTIVES

Polyacrylamide hydrogel (PAAG, Aquamid) is widely used as permanent facial tissue filler during facial plastic surgery. In this study, we examined the long-term effects and safety aspects of PAAG as a vocal fold augmentation material for patients with permanent unilateral vocal cord paralysis.

STUDY DESIGN

Prospective clinical trials.

METHODS

PAAG injection laryngoplasty was performed in 34 consecutive patients with permanent unilateral vocal cord paralysis. Percutaneous injection was performed under local anesthesia into the vocalis muscle using disposable 25 gauge long needles. Of the 34 patients, 16 completed acoustic, perceptual, stroboscopic, and subjective evaluations prior to the injection and at 6 and 12 months after the injection.

RESULTS

Acoustic and perceptual parameters (GRBAS [Overall grade of dysphonia, Roughness, Breathiness, Aesthenia, Strain], Maximal phonation time [MPT], jitter, and shimmer) were significantly improved (P < .05) after injection and remained stable over 12 months. The grades of mucosal waves and glottic closure were also significantly improved (P < .01). The voice handicap index (VHI), as well as the visual analogue scale (VAS) of hoarseness and aspiration significantly improved over 12 months. No adverse effects were observed except for a decrease in the mucosal wave of one patient, after injection into a superficial area of the vocal fold.

CONCLUSION

Based on the preliminary results of this trial, PAAG appears to be a long-lasting and safe injection material that is suitable for the treatment of glottal insufficiency caused by permanent unilateral vocal cord paralysis.

Authors+Show Affiliations

Department of Otolaryngology-Head and Neck Surgery, Soonchunhyang University College of Medicine, Bucheon, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17690620

Citation

Lee, Seung Won, et al. "Voice Outcomes of Polyacrylamide Hydrogel Injection Laryngoplasty." The Laryngoscope, vol. 117, no. 10, 2007, pp. 1871-5.
Lee SW, Son YI, Kim CH, et al. Voice outcomes of polyacrylamide hydrogel injection laryngoplasty. Laryngoscope. 2007;117(10):1871-5.
Lee, S. W., Son, Y. I., Kim, C. H., Lee, J. Y., Kim, S. C., & Koh, Y. W. (2007). Voice outcomes of polyacrylamide hydrogel injection laryngoplasty. The Laryngoscope, 117(10), 1871-5.
Lee SW, et al. Voice Outcomes of Polyacrylamide Hydrogel Injection Laryngoplasty. Laryngoscope. 2007;117(10):1871-5. PubMed PMID: 17690620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Voice outcomes of polyacrylamide hydrogel injection laryngoplasty. AU - Lee,Seung Won, AU - Son,Young-Ik, AU - Kim,Chan Hee, AU - Lee,Jae Yong, AU - Kim,Shi Chan, AU - Koh,Yoon Woo, PY - 2007/8/11/pubmed PY - 2007/12/6/medline PY - 2007/8/11/entrez SP - 1871 EP - 5 JF - The Laryngoscope JO - Laryngoscope VL - 117 IS - 10 N2 - OBJECTIVES: Polyacrylamide hydrogel (PAAG, Aquamid) is widely used as permanent facial tissue filler during facial plastic surgery. In this study, we examined the long-term effects and safety aspects of PAAG as a vocal fold augmentation material for patients with permanent unilateral vocal cord paralysis. STUDY DESIGN: Prospective clinical trials. METHODS: PAAG injection laryngoplasty was performed in 34 consecutive patients with permanent unilateral vocal cord paralysis. Percutaneous injection was performed under local anesthesia into the vocalis muscle using disposable 25 gauge long needles. Of the 34 patients, 16 completed acoustic, perceptual, stroboscopic, and subjective evaluations prior to the injection and at 6 and 12 months after the injection. RESULTS: Acoustic and perceptual parameters (GRBAS [Overall grade of dysphonia, Roughness, Breathiness, Aesthenia, Strain], Maximal phonation time [MPT], jitter, and shimmer) were significantly improved (P < .05) after injection and remained stable over 12 months. The grades of mucosal waves and glottic closure were also significantly improved (P < .01). The voice handicap index (VHI), as well as the visual analogue scale (VAS) of hoarseness and aspiration significantly improved over 12 months. No adverse effects were observed except for a decrease in the mucosal wave of one patient, after injection into a superficial area of the vocal fold. CONCLUSION: Based on the preliminary results of this trial, PAAG appears to be a long-lasting and safe injection material that is suitable for the treatment of glottal insufficiency caused by permanent unilateral vocal cord paralysis. SN - 0023-852X UR - https://www.unboundmedicine.com/medline/citation/17690620/Voice_outcomes_of_polyacrylamide_hydrogel_injection_laryngoplasty_ L2 - https://doi.org/10.1097/MLG.0b013e3180caa1b1 DB - PRIME DP - Unbound Medicine ER -