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Organocatalytic and highly enantioselective direct alpha-amination of aromatic ketones.
Org Lett. 2007 Aug 30; 9(18):3671-4.OL

Abstract

The first highly enantioselective direct alpha-amination of aryl ketones was reported to be catalyzed by organic primary amines derived from cinchona alkaloids. Excellent enantioselectivities (88-99% ee) have been achieved for a broad spectrum of aryl ketones. The presence of 4 A molecular sieves was of great assistance for the high conversions and enantiocontrol.

Authors+Show Affiliations

Liu TY
Key Laboratory of Drug-Targeting of Education Ministry and Department of Medicinal Chemistry, West China School of Pharmacy, Sichuan University, and State Key Laboratory of Biotherapy, West China Hospital, Chengdu, China.
Cui HL
No affiliation info available
Zhang Y
No affiliation info available
Jiang K
No affiliation info available
Du W
No affiliation info available
He ZQ
No affiliation info available
Chen YC
No affiliation info available

MeSH

AminationAminesCatalysisHydrocarbons, AromaticKetonesOrganic ChemicalsStereoisomerism

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17691800

Citation

Liu, Tian-Yu, et al. "Organocatalytic and Highly Enantioselective Direct Alpha-amination of Aromatic Ketones." Organic Letters, vol. 9, no. 18, 2007, pp. 3671-4.
Liu TY, Cui HL, Zhang Y, et al. Organocatalytic and highly enantioselective direct alpha-amination of aromatic ketones. Org Lett. 2007;9(18):3671-4.
Liu, T. Y., Cui, H. L., Zhang, Y., Jiang, K., Du, W., He, Z. Q., & Chen, Y. C. (2007). Organocatalytic and highly enantioselective direct alpha-amination of aromatic ketones. Organic Letters, 9(18), 3671-4.
Liu TY, et al. Organocatalytic and Highly Enantioselective Direct Alpha-amination of Aromatic Ketones. Org Lett. 2007 Aug 30;9(18):3671-4. PubMed PMID: 17691800.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Organocatalytic and highly enantioselective direct alpha-amination of aromatic ketones. AU - Liu,Tian-Yu, AU - Cui,Hai-Lei, AU - Zhang,Yan, AU - Jiang,Kun, AU - Du,Wei, AU - He,Zhao-Quan, AU - Chen,Ying-Chun, Y1 - 2007/08/11/ PY - 2007/8/19/pubmed PY - 2007/11/10/medline PY - 2007/8/19/entrez SP - 3671 EP - 4 JF - Organic letters JO - Org Lett VL - 9 IS - 18 N2 - The first highly enantioselective direct alpha-amination of aryl ketones was reported to be catalyzed by organic primary amines derived from cinchona alkaloids. Excellent enantioselectivities (88-99% ee) have been achieved for a broad spectrum of aryl ketones. The presence of 4 A molecular sieves was of great assistance for the high conversions and enantiocontrol. SN - 1523-7060 UR - https://www.unboundmedicine.com/medline/citation/17691800/Organocatalytic_and_highly_enantioselective_direct_alpha_amination_of_aromatic_ketones_ DB - PRIME DP - Unbound Medicine ER -