Tags

Type your tag names separated by a space and hit enter

Anti-arrhythmic properties of N-3 poly-unsaturated fatty acids (n-3 PUFA).
Curr Med Chem. 2007; 14(19):2070-80.CM

Abstract

Omega-3 fatty acids (Poly-Unsaturated Fatty Acids or PUFA n-3) have been initially found to reduce plasma levels of triglycerides and to increase levels of high-density lipoprotein in patients with marked hypertriglyceridemia. However, in both bench research studies and clinical trials, omega-3 fatty acid intake has recently been associated with an anti-arrhythmic efficacy. At experimental level, n-3 PUFA administration produces several actions on ionic channels regulating transmembrane action potential. At clinical level, the most significant finding was the reduction in the incidence of sudden death in survivors of MI in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevention trial and the subsequent recommendation for administration of fish oil as part of the post-infarction regimen in European guidelines. More recently, Omega-3 fatty acids administration has been associated with a lower incidence of atrial fibrillation in patients who underwent cardiac surgery. Contrasting results have been instead reported in patients with implantable cardioverter defibrillators. This article reviews in detail the basic and clinical research studies of fish oil as an anti-arrhythmic entity, the types of arrhythmias that have been beneficially affected by fish oil administration, and the presumed and known mechanisms by which the beneficial actions are exerted.

Authors+Show Affiliations

Cardiologia, Dipartimento di Medicina, Chirurgia e Odontoiatria, Osp. San Paolo, University of Milan, Milan, Italy. Federico.Lombardi@unimi.itNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

17691948

Citation

Lombardi, Federico, and Paolo Terranova. "Anti-arrhythmic Properties of N-3 Poly-unsaturated Fatty Acids (n-3 PUFA)." Current Medicinal Chemistry, vol. 14, no. 19, 2007, pp. 2070-80.
Lombardi F, Terranova P. Anti-arrhythmic properties of N-3 poly-unsaturated fatty acids (n-3 PUFA). Curr Med Chem. 2007;14(19):2070-80.
Lombardi, F., & Terranova, P. (2007). Anti-arrhythmic properties of N-3 poly-unsaturated fatty acids (n-3 PUFA). Current Medicinal Chemistry, 14(19), 2070-80.
Lombardi F, Terranova P. Anti-arrhythmic Properties of N-3 Poly-unsaturated Fatty Acids (n-3 PUFA). Curr Med Chem. 2007;14(19):2070-80. PubMed PMID: 17691948.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Anti-arrhythmic properties of N-3 poly-unsaturated fatty acids (n-3 PUFA). AU - Lombardi,Federico, AU - Terranova,Paolo, PY - 2007/8/19/pubmed PY - 2007/9/19/medline PY - 2007/8/19/entrez SP - 2070 EP - 80 JF - Current medicinal chemistry JO - Curr. Med. Chem. VL - 14 IS - 19 N2 - Omega-3 fatty acids (Poly-Unsaturated Fatty Acids or PUFA n-3) have been initially found to reduce plasma levels of triglycerides and to increase levels of high-density lipoprotein in patients with marked hypertriglyceridemia. However, in both bench research studies and clinical trials, omega-3 fatty acid intake has recently been associated with an anti-arrhythmic efficacy. At experimental level, n-3 PUFA administration produces several actions on ionic channels regulating transmembrane action potential. At clinical level, the most significant finding was the reduction in the incidence of sudden death in survivors of MI in the Gruppo Italiano per lo Studio della Sopravvivenza nell'Infarto Miocardico (GISSI)-Prevention trial and the subsequent recommendation for administration of fish oil as part of the post-infarction regimen in European guidelines. More recently, Omega-3 fatty acids administration has been associated with a lower incidence of atrial fibrillation in patients who underwent cardiac surgery. Contrasting results have been instead reported in patients with implantable cardioverter defibrillators. This article reviews in detail the basic and clinical research studies of fish oil as an anti-arrhythmic entity, the types of arrhythmias that have been beneficially affected by fish oil administration, and the presumed and known mechanisms by which the beneficial actions are exerted. SN - 0929-8673 UR - https://www.unboundmedicine.com/medline/citation/17691948/Anti_arrhythmic_properties_of_N_3_poly_unsaturated_fatty_acids__n_3_PUFA__ L2 - http://www.eurekaselect.com/59625/article DB - PRIME DP - Unbound Medicine ER -