Tags

Type your tag names separated by a space and hit enter

Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose.
Biochem Pharmacol. 2007 Oct 01; 74(7):1078-90.BP

Abstract

Ursolic acid (UA), a pentracyclic triterpene, is reported to have an antioxidant activity. Here we assessed the protective effect of UA against the d-galactose (D-gal)-induced neurotoxicity. We found that UA markedly reversed the D-gal induced learning and memory impairment by behavioral tests. The following antioxidant defense enzymes were measured: superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR). The content of the lipid peroxidation product malondialdehyde (MDA) was also analyzed. Our results indicated that the neuroprotective effect of UA against D-gal induced neurotoxicity might be caused, at least in part, by the increase in the activity of antioxidant enzymes with a reduction in lipid peroxidation. And UA also inhibited the activation of caspase-3 induced by D-gal. Furthermore, we found that UA significantly increased the level of growth-associated protein GAP43 in the brain of D-gal-treated mice. These results suggest that the pharmacological action of UA may offer a novel therapeutic strategy for the treatment of age-related conditions.

Authors+Show Affiliations

Key Laboratory for Biotechnology on Medicinal Plants of Jiangsu Province, Xuzhou Normal University, Xuzhou 221116, PR China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17692828

Citation

Lu, Jun, et al. "Ursolic Acid Ameliorates Cognition Deficits and Attenuates Oxidative Damage in the Brain of Senescent Mice Induced By D-galactose." Biochemical Pharmacology, vol. 74, no. 7, 2007, pp. 1078-90.
Lu J, Zheng YL, Wu DM, et al. Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Biochem Pharmacol. 2007;74(7):1078-90.
Lu, J., Zheng, Y. L., Wu, D. M., Luo, L., Sun, D. X., & Shan, Q. (2007). Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Biochemical Pharmacology, 74(7), 1078-90.
Lu J, et al. Ursolic Acid Ameliorates Cognition Deficits and Attenuates Oxidative Damage in the Brain of Senescent Mice Induced By D-galactose. Biochem Pharmacol. 2007 Oct 1;74(7):1078-90. PubMed PMID: 17692828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ursolic acid ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. AU - Lu,Jun, AU - Zheng,Yuan-Lin, AU - Wu,Dong-Mei, AU - Luo,Lan, AU - Sun,Dong-Xu, AU - Shan,Qun, Y1 - 2007/07/10/ PY - 2007/06/11/received PY - 2007/07/01/revised PY - 2007/07/02/accepted PY - 2007/8/19/pubmed PY - 2007/10/20/medline PY - 2007/8/19/entrez SP - 1078 EP - 90 JF - Biochemical pharmacology JO - Biochem Pharmacol VL - 74 IS - 7 N2 - Ursolic acid (UA), a pentracyclic triterpene, is reported to have an antioxidant activity. Here we assessed the protective effect of UA against the d-galactose (D-gal)-induced neurotoxicity. We found that UA markedly reversed the D-gal induced learning and memory impairment by behavioral tests. The following antioxidant defense enzymes were measured: superoxide dismutases (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione reductase (GR). The content of the lipid peroxidation product malondialdehyde (MDA) was also analyzed. Our results indicated that the neuroprotective effect of UA against D-gal induced neurotoxicity might be caused, at least in part, by the increase in the activity of antioxidant enzymes with a reduction in lipid peroxidation. And UA also inhibited the activation of caspase-3 induced by D-gal. Furthermore, we found that UA significantly increased the level of growth-associated protein GAP43 in the brain of D-gal-treated mice. These results suggest that the pharmacological action of UA may offer a novel therapeutic strategy for the treatment of age-related conditions. SN - 0006-2952 UR - https://www.unboundmedicine.com/medline/citation/17692828/Ursolic_acid_ameliorates_cognition_deficits_and_attenuates_oxidative_damage_in_the_brain_of_senescent_mice_induced_by_D_galactose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-2952(07)00433-9 DB - PRIME DP - Unbound Medicine ER -