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Breath condensate nitrite correlates with hyperinflation in chronic obstructive pulmonary disease.
Respir Med. 2007 Nov; 101(11):2271-8.RM

Abstract

Estimating the degree of pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) is not always straight forward. Standard pulmonary function tests provide only a crude estimate of this important aspect of COPD. In addition, good patient cooperation cannot always be achieved and therefore adds to the uncertainties with regard to the extent of hyperinflation of the lung. The aim of this investigation was to characterize exhaled breath condensate nitrite in volunteers, healthy smokers, and stable COPD (GOLD-stages 0-4) and to compare this parameter with inflammatory markers in exhaled breath condensate and with lung function in order to test the hypothesis that elevated exhaled breath condensate nitrite reflects hyperinflation in COPD. We found a logarithmic correlation of exhaled breath condensate nitrite to residual volume (r=0.75, p<0.0001), total lung capacity (r=0.51, p<0.0001), and thoracic gas volume (r=0.71, p<0.0001) but no correlation of exhaled breath condensate nitrite concentrations with levels of inflammatory cytokines in exhaled breath condensate (interleukin (IL)-8, IL-1beta, IL-6, IL-10, IL-12, and tumor necrosis factor-alpha). Analysis of COPD subgroups revealed a logarithmic correlation of EBC nitrite to residual volume, total lung capacity, and intrathoracic gas volume exclusively for patients characterized by GOLD classes 2, and higher. Our results confirm a relation of exhaled breath condensate nitrite levels and hyperinflation measured by conventional pulmonary function tests. Investigations using isolated lung models and cells stretched in culture also provide insight into this relation. Exhaled breath condensate nitrite may be a biochemical indicator of pulmonary overdistension.

Authors+Show Affiliations

Department of Respiratory Medicine, University of Leipzig, Johannisallee 32, 04103 Leipzig, Germany. ch.gessner@web.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17693071

Citation

Gessner, Christian, et al. "Breath Condensate Nitrite Correlates With Hyperinflation in Chronic Obstructive Pulmonary Disease." Respiratory Medicine, vol. 101, no. 11, 2007, pp. 2271-8.
Gessner C, Hammerschmidt S, Kuhn H, et al. Breath condensate nitrite correlates with hyperinflation in chronic obstructive pulmonary disease. Respir Med. 2007;101(11):2271-8.
Gessner, C., Hammerschmidt, S., Kuhn, H., Hoheisel, G., Gillissen, A., Sack, U., & Wirtz, H. (2007). Breath condensate nitrite correlates with hyperinflation in chronic obstructive pulmonary disease. Respiratory Medicine, 101(11), 2271-8.
Gessner C, et al. Breath Condensate Nitrite Correlates With Hyperinflation in Chronic Obstructive Pulmonary Disease. Respir Med. 2007;101(11):2271-8. PubMed PMID: 17693071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Breath condensate nitrite correlates with hyperinflation in chronic obstructive pulmonary disease. AU - Gessner,Christian, AU - Hammerschmidt,Stefan, AU - Kuhn,Hartmut, AU - Hoheisel,Gerhard, AU - Gillissen,Adrian, AU - Sack,Ulrich, AU - Wirtz,Hubert, Y1 - 2007/08/10/ PY - 2006/08/16/received PY - 2007/06/18/revised PY - 2007/06/26/accepted PY - 2007/8/19/pubmed PY - 2008/4/22/medline PY - 2007/8/19/entrez SP - 2271 EP - 8 JF - Respiratory medicine JO - Respir Med VL - 101 IS - 11 N2 - Estimating the degree of pulmonary hyperinflation in chronic obstructive pulmonary disease (COPD) is not always straight forward. Standard pulmonary function tests provide only a crude estimate of this important aspect of COPD. In addition, good patient cooperation cannot always be achieved and therefore adds to the uncertainties with regard to the extent of hyperinflation of the lung. The aim of this investigation was to characterize exhaled breath condensate nitrite in volunteers, healthy smokers, and stable COPD (GOLD-stages 0-4) and to compare this parameter with inflammatory markers in exhaled breath condensate and with lung function in order to test the hypothesis that elevated exhaled breath condensate nitrite reflects hyperinflation in COPD. We found a logarithmic correlation of exhaled breath condensate nitrite to residual volume (r=0.75, p<0.0001), total lung capacity (r=0.51, p<0.0001), and thoracic gas volume (r=0.71, p<0.0001) but no correlation of exhaled breath condensate nitrite concentrations with levels of inflammatory cytokines in exhaled breath condensate (interleukin (IL)-8, IL-1beta, IL-6, IL-10, IL-12, and tumor necrosis factor-alpha). Analysis of COPD subgroups revealed a logarithmic correlation of EBC nitrite to residual volume, total lung capacity, and intrathoracic gas volume exclusively for patients characterized by GOLD classes 2, and higher. Our results confirm a relation of exhaled breath condensate nitrite levels and hyperinflation measured by conventional pulmonary function tests. Investigations using isolated lung models and cells stretched in culture also provide insight into this relation. Exhaled breath condensate nitrite may be a biochemical indicator of pulmonary overdistension. SN - 0954-6111 UR - https://www.unboundmedicine.com/medline/citation/17693071/Breath_condensate_nitrite_correlates_with_hyperinflation_in_chronic_obstructive_pulmonary_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0954-6111(07)00279-X DB - PRIME DP - Unbound Medicine ER -