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Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats.
Growth Horm IGF Res. 2008 Feb; 18(1):75-81.GH

Abstract

OBJECTIVE

Plasma levels of insulin-like growth factor-I (IGF-I), an important substance for maintaining cardiovascular homeostasis, are lower in spontaneously hypertensive rats (SHR) than in normotensive Wistar Kyoto rats (WKY). Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR.

DESIGN

Levels of CGRP and IGF-I in plasma, kidneys and heart in WKY and SHR and cellular cyclic AMP levels in dorsal root ganglion neurons (DRGs) isolated from WKY and SHR were measured by an ELISA-based method.

RESULTS

Levels of CGRP and IGF-I in plasma, kidneys and heart of SHR were about half of those of WKY. Administration of capsaicin significantly increased levels of CGRP and IGF-I in plasma and tissues of SHR to the levels in WKY and these increases were completely reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation. CGRP release and cellular levels of cAMP in DRGs isolated from SHR were significantly lower than those in DRGs isolated from WKY. Capsaicin increased both CGRP release and cellular cAMP levels in DRGs isolated from SHR to the levels in DRGs isolated from WKY.

CONCLUSIONS

Sensory neuron activation might be lower in SHR than in WKY probably due to decreased production of cAMP in sensory neurons, explaining why IGF-I levels in plasma and tissues are lower in SHR than in WKY.

Authors+Show Affiliations

Department of Translational Medical Science Research, Nagoya City University, Graduate School of Medical Sciences, Nagoya, Japan.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17693108

Citation

Harada, Naoaki, and Kenji Okajima. "Effect of Capsaicin On Plasma and Tissue Levels of Insulin-like Growth factor-I in Spontaneously Hypertensive Rats." Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, vol. 18, no. 1, 2008, pp. 75-81.
Harada N, Okajima K. Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats. Growth Horm IGF Res. 2008;18(1):75-81.
Harada, N., & Okajima, K. (2008). Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats. Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society, 18(1), 75-81.
Harada N, Okajima K. Effect of Capsaicin On Plasma and Tissue Levels of Insulin-like Growth factor-I in Spontaneously Hypertensive Rats. Growth Horm IGF Res. 2008;18(1):75-81. PubMed PMID: 17693108.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of capsaicin on plasma and tissue levels of insulin-like growth factor-I in spontaneously hypertensive rats. AU - Harada,Naoaki, AU - Okajima,Kenji, Y1 - 2007/08/10/ PY - 2007/01/23/received PY - 2007/06/07/revised PY - 2007/06/26/accepted PY - 2007/8/19/pubmed PY - 2008/6/6/medline PY - 2007/8/19/entrez SP - 75 EP - 81 JF - Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society JO - Growth Horm IGF Res VL - 18 IS - 1 N2 - OBJECTIVE: Plasma levels of insulin-like growth factor-I (IGF-I), an important substance for maintaining cardiovascular homeostasis, are lower in spontaneously hypertensive rats (SHR) than in normotensive Wistar Kyoto rats (WKY). Calcitonin gene-related peptide (CGRP) increases IGF-I production in vitro and in vivo, suggesting that stimulation of sensory neurons might increase the production of IGF-I in SHR. DESIGN: Levels of CGRP and IGF-I in plasma, kidneys and heart in WKY and SHR and cellular cyclic AMP levels in dorsal root ganglion neurons (DRGs) isolated from WKY and SHR were measured by an ELISA-based method. RESULTS: Levels of CGRP and IGF-I in plasma, kidneys and heart of SHR were about half of those of WKY. Administration of capsaicin significantly increased levels of CGRP and IGF-I in plasma and tissues of SHR to the levels in WKY and these increases were completely reversed by pretreatment with capsazepine, an inhibitor of vanilloid receptor-1 activation. CGRP release and cellular levels of cAMP in DRGs isolated from SHR were significantly lower than those in DRGs isolated from WKY. Capsaicin increased both CGRP release and cellular cAMP levels in DRGs isolated from SHR to the levels in DRGs isolated from WKY. CONCLUSIONS: Sensory neuron activation might be lower in SHR than in WKY probably due to decreased production of cAMP in sensory neurons, explaining why IGF-I levels in plasma and tissues are lower in SHR than in WKY. SN - 1096-6374 UR - https://www.unboundmedicine.com/medline/citation/17693108/Effect_of_capsaicin_on_plasma_and_tissue_levels_of_insulin_like_growth_factor_I_in_spontaneously_hypertensive_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1096-6374(07)00089-5 DB - PRIME DP - Unbound Medicine ER -