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[Cigarette smoking, alcohol consumption, tuberculosis and risk of lung cancer: the Korean multi-center cancer cohort study].
J Prev Med Public Health 2007; 40(4):321-8JP

Abstract

OBJECTIVES

The aim of this study was to evaluate the roles of cigarette smoking, alcohol consumption, tuberculosis, and their interactions in the risk of lung cancer in a Korean cohort.

METHODS

The study subjects comprised 13,150 males and females aged above 20 years old. During the follow up period from 1993 to 2002, 79 lung cancer cases were identified by the central cancer registry and the national death certificate database. Information on cigarette smoking, alcohol consumption and the history of physician-diagnosed tuberculosis was obtained by interview. Indirect chest X-ray findings were also evaluated to ascertain tuberculosis cases. Cox proportional hazard models were used to estimate relative risks (RR) and 95% confidence intervals (CI) after adjusting for age and gender.

RESULTS

Cigarette smoking was statistically significantly associated with an increased risk of lung cancer [for current smokers, RR = 2.33 (95% CI = 1.23 - 4.42) compared to non-smokers]. After further adjustment for cigarette smoking, both alcohol consumption and tuberculosis showed no statistically significant association with the risk of lung cancer [for current drinkers, RR = 0.80 (95% CI = 0.48 - 1.33) compared to non-drinkers] [for tuberculosis cases, RR = 1.17 (95% CI = 0.58 - 2.36) compared to non-cases]. There was no statistically significant interaction between cigarette smoking and alcohol consumption (p-interaction = 0.38), or cigarette smoking and tuberculosis (p-interaction = 0.74).

CONCLUSIONS

Although cigarette smoking was confirmed as a risk factor of lung cancer in this cohort study, this study suggests that alcohol consumption and tuberculosis may not be associated with the risk of lung cancer.

Authors+Show Affiliations

Department of Preventive Medicine, Seoul National University College of Medicine, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Multicenter Study

Language

kor

PubMed ID

17693736

Citation

Bae, Jisuk, et al. "[Cigarette Smoking, Alcohol Consumption, Tuberculosis and Risk of Lung Cancer: the Korean Multi-center Cancer Cohort Study]." Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, vol. 40, no. 4, 2007, pp. 321-8.
Bae J, Gwack J, Park SK, et al. [Cigarette smoking, alcohol consumption, tuberculosis and risk of lung cancer: the Korean multi-center cancer cohort study]. J Prev Med Public Health. 2007;40(4):321-8.
Bae, J., Gwack, J., Park, S. K., Shin, H. R., Chang, S. H., & Yoo, K. Y. (2007). [Cigarette smoking, alcohol consumption, tuberculosis and risk of lung cancer: the Korean multi-center cancer cohort study]. Journal of Preventive Medicine and Public Health = Yebang Uihakhoe Chi, 40(4), pp. 321-8.
Bae J, et al. [Cigarette Smoking, Alcohol Consumption, Tuberculosis and Risk of Lung Cancer: the Korean Multi-center Cancer Cohort Study]. J Prev Med Public Health. 2007;40(4):321-8. PubMed PMID: 17693736.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Cigarette smoking, alcohol consumption, tuberculosis and risk of lung cancer: the Korean multi-center cancer cohort study]. AU - Bae,Jisuk, AU - Gwack,Jin, AU - Park,Sue Kyung, AU - Shin,Hai-Rim, AU - Chang,Soung-Hoon, AU - Yoo,Keun-Young, PY - 2007/8/19/pubmed PY - 2007/9/14/medline PY - 2007/8/19/entrez SP - 321 EP - 8 JF - Journal of preventive medicine and public health = Yebang Uihakhoe chi JO - J Prev Med Public Health VL - 40 IS - 4 N2 - OBJECTIVES: The aim of this study was to evaluate the roles of cigarette smoking, alcohol consumption, tuberculosis, and their interactions in the risk of lung cancer in a Korean cohort. METHODS: The study subjects comprised 13,150 males and females aged above 20 years old. During the follow up period from 1993 to 2002, 79 lung cancer cases were identified by the central cancer registry and the national death certificate database. Information on cigarette smoking, alcohol consumption and the history of physician-diagnosed tuberculosis was obtained by interview. Indirect chest X-ray findings were also evaluated to ascertain tuberculosis cases. Cox proportional hazard models were used to estimate relative risks (RR) and 95% confidence intervals (CI) after adjusting for age and gender. RESULTS: Cigarette smoking was statistically significantly associated with an increased risk of lung cancer [for current smokers, RR = 2.33 (95% CI = 1.23 - 4.42) compared to non-smokers]. After further adjustment for cigarette smoking, both alcohol consumption and tuberculosis showed no statistically significant association with the risk of lung cancer [for current drinkers, RR = 0.80 (95% CI = 0.48 - 1.33) compared to non-drinkers] [for tuberculosis cases, RR = 1.17 (95% CI = 0.58 - 2.36) compared to non-cases]. There was no statistically significant interaction between cigarette smoking and alcohol consumption (p-interaction = 0.38), or cigarette smoking and tuberculosis (p-interaction = 0.74). CONCLUSIONS: Although cigarette smoking was confirmed as a risk factor of lung cancer in this cohort study, this study suggests that alcohol consumption and tuberculosis may not be associated with the risk of lung cancer. SN - 1975-8375 UR - https://www.unboundmedicine.com/medline/citation/17693736/[Cigarette_smoking_alcohol_consumption_tuberculosis_and_risk_of_lung_cancer:_the_Korean_multi_center_cancer_cohort_study]_ L2 - http://www.diseaseinfosearch.org/result/4334 DB - PRIME DP - Unbound Medicine ER -