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Circadian rhythm of salivary serotonin in patients with major depressive disorder.
Neuro Endocrinol Lett. 2007 Aug; 28(4):395-400.NE

Abstract

OBJECTIVES

The present study aimed to explore the circadian rhythm of salivary serotonin in patients with major depressive disorder before and after treatment with fluoxetine and its relationship with clinical therapeutic effect.

METHODS

This study investigated salivary serotonin in 13 outpatients with major depressive disorder and age- and sex-matched healthy controls. Depressed patients received six weeks fluoxetine treatment (20 mg/day), saliva was collected before and four weeks after treatment. A total of 8 time-point salivary serotonin was measured across the whole day. Multi-oscillator cosinor model was used to fit the rhythms.

RESULTS

Serotonin concentration in saliva ranged from 0.32 ng/ml to 9.62 ng/ml. Salivary serotonin showed prominent circadian rhythm in 91% depressed patients and 92% healthy subjects. Circadian amplitude tend to be higher after fluoxetine treatment in depressed patients, so as the ultradian cycle amplitude. The serotonin circadian amplitude (After minus Before) was positively correlated with the decrease of Zung Self-Rating Depression Scale(SDS) scores at day 42 whereas there was no such correlation at day 28. There was no significant difference in the parameters of mesor, acrophase, harmonic and area under curve among three groups.

CONCLUSIONS

Salivary serotonin in patients with major depressive disorder showed clear circadian rhythm. The relationship between the increase of salivary serotonin amplitude and clinical response deserve further study.

Authors+Show Affiliations

Hefei National Laboratory for Physical Sciences at Microscale, and Department of Neurobiology, School of Life Science, University of Science and Technology of China, Hefei Jinzhai Road 96, Anhui 230026, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17693970

Citation

Tan, Zhong-Lin, et al. "Circadian Rhythm of Salivary Serotonin in Patients With Major Depressive Disorder." Neuro Endocrinology Letters, vol. 28, no. 4, 2007, pp. 395-400.
Tan ZL, Bao AM, Tao M, et al. Circadian rhythm of salivary serotonin in patients with major depressive disorder. Neuro Endocrinol Lett. 2007;28(4):395-400.
Tan, Z. L., Bao, A. M., Tao, M., Liu, Y. J., & Zhou, J. N. (2007). Circadian rhythm of salivary serotonin in patients with major depressive disorder. Neuro Endocrinology Letters, 28(4), 395-400.
Tan ZL, et al. Circadian Rhythm of Salivary Serotonin in Patients With Major Depressive Disorder. Neuro Endocrinol Lett. 2007;28(4):395-400. PubMed PMID: 17693970.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circadian rhythm of salivary serotonin in patients with major depressive disorder. AU - Tan,Zhong-Lin, AU - Bao,Ai-Min, AU - Tao,Ming, AU - Liu,Ya-Jing, AU - Zhou,Jiang-Ning, PY - 2007/04/22/received PY - 2007/04/30/accepted PY - 2007/8/19/pubmed PY - 2008/1/25/medline PY - 2007/8/19/entrez SP - 395 EP - 400 JF - Neuro endocrinology letters JO - Neuro Endocrinol Lett VL - 28 IS - 4 N2 - OBJECTIVES: The present study aimed to explore the circadian rhythm of salivary serotonin in patients with major depressive disorder before and after treatment with fluoxetine and its relationship with clinical therapeutic effect. METHODS: This study investigated salivary serotonin in 13 outpatients with major depressive disorder and age- and sex-matched healthy controls. Depressed patients received six weeks fluoxetine treatment (20 mg/day), saliva was collected before and four weeks after treatment. A total of 8 time-point salivary serotonin was measured across the whole day. Multi-oscillator cosinor model was used to fit the rhythms. RESULTS: Serotonin concentration in saliva ranged from 0.32 ng/ml to 9.62 ng/ml. Salivary serotonin showed prominent circadian rhythm in 91% depressed patients and 92% healthy subjects. Circadian amplitude tend to be higher after fluoxetine treatment in depressed patients, so as the ultradian cycle amplitude. The serotonin circadian amplitude (After minus Before) was positively correlated with the decrease of Zung Self-Rating Depression Scale(SDS) scores at day 42 whereas there was no such correlation at day 28. There was no significant difference in the parameters of mesor, acrophase, harmonic and area under curve among three groups. CONCLUSIONS: Salivary serotonin in patients with major depressive disorder showed clear circadian rhythm. The relationship between the increase of salivary serotonin amplitude and clinical response deserve further study. SN - 0172-780X UR - https://www.unboundmedicine.com/medline/citation/17693970/Circadian_rhythm_of_salivary_serotonin_in_patients_with_major_depressive_disorder_ L2 - http://www.diseaseinfosearch.org/result/8782 DB - PRIME DP - Unbound Medicine ER -