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Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: a case report.
J Reprod Med. 2007 Jun; 52(6):575-6.JR

Abstract

BACKGROUND

Use of Dartmouth combination chemotherapy in pregnancy is scarcely reported, with only 1 report of its use in the late second and third trimesters and no report of its use in the first trimester.

CASE

This is the first reported case in which the Dartmouth combination chemotherapy regimen was inadvertently used in a pregnant woman during the first and second trimesters for treatment of metastatic melanoma. The infant was found to have isolated microphthalmos and severe hypermetropia at 1 year of age.

CONCLUSION

Although a causal relationship cannot be established from a single case, this report does provide useful information to discourage the use of this chemotherapy regimen in the first trimester, which is the critical period for organogenesis.

Authors+Show Affiliations

Department of Obstetrics and Gynaecology, Chinese University of Hong Kong, Prince of Wales Hospital, 30-32 Ngan Shing Street, Shatin, N.T., Hong Kong SAR, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

17694989

Citation

Li, Raymond Hang Wun, et al. "Microphthalmos Associated With Dartmouth Combination Chemotherapy in Pregnancy: a Case Report." The Journal of Reproductive Medicine, vol. 52, no. 6, 2007, pp. 575-6.
Li RH, Tam WH, Ng PC, et al. Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: a case report. J Reprod Med. 2007;52(6):575-6.
Li, R. H., Tam, W. H., Ng, P. C., Mok, T. S., Tam, B., & Lau, T. K. (2007). Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: a case report. The Journal of Reproductive Medicine, 52(6), 575-6.
Li RH, et al. Microphthalmos Associated With Dartmouth Combination Chemotherapy in Pregnancy: a Case Report. J Reprod Med. 2007;52(6):575-6. PubMed PMID: 17694989.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microphthalmos associated with Dartmouth combination chemotherapy in pregnancy: a case report. AU - Li,Raymond Hang Wun, AU - Tam,Wing Hung, AU - Ng,Pak Cheung, AU - Mok,Tony Shu Kam, AU - Tam,Barbara, AU - Lau,Tze Kin, PY - 2007/8/19/pubmed PY - 2007/9/14/medline PY - 2007/8/19/entrez SP - 575 EP - 6 JF - The Journal of reproductive medicine JO - J Reprod Med VL - 52 IS - 6 N2 - BACKGROUND: Use of Dartmouth combination chemotherapy in pregnancy is scarcely reported, with only 1 report of its use in the late second and third trimesters and no report of its use in the first trimester. CASE: This is the first reported case in which the Dartmouth combination chemotherapy regimen was inadvertently used in a pregnant woman during the first and second trimesters for treatment of metastatic melanoma. The infant was found to have isolated microphthalmos and severe hypermetropia at 1 year of age. CONCLUSION: Although a causal relationship cannot be established from a single case, this report does provide useful information to discourage the use of this chemotherapy regimen in the first trimester, which is the critical period for organogenesis. SN - 0024-7758 UR - https://www.unboundmedicine.com/medline/citation/17694989/Microphthalmos_associated_with_Dartmouth_combination_chemotherapy_in_pregnancy:_a_case_report_ L2 - http://www.diseaseinfosearch.org/result/5922 DB - PRIME DP - Unbound Medicine ER -