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Fear conditioning in panic disorder: Enhanced resistance to extinction.
J Abnorm Psychol. 2007 Aug; 116(3):612-7.JA

Abstract

Enhanced conditionability has been proposed as a crucial factor in the etiology and maintenance of panic disorder (PD). To test this assumption, the authors of the current study examined the acquisition and extinction of conditioned responses to aversive stimuli in PD. Thirty-nine PD patients and 33 healthy control participants took part in a differential aversive conditioning experiment. A highly annoying but not painful electrical stimulus served as the unconditioned stimulus (US), and two neutral pictures were used as either the paired conditioned stimulus (CS+) or the unpaired conditioned stimulus (CS-). Results indicate that PD patients do not show larger conditioned responses during acquisition than control participants. However, in contrast to control participants, PD patients exhibited larger skin conductance responses to CS+ stimuli during extinction and maintained a more negative evaluation of them, as indicated by valence ratings obtained several times throughout the experiment. This suggests that PD patients show enhanced conditionability with respect to extinction.

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Authors+Show Affiliations

Michael T
Department of Clinical Psychology and Psychotherapy, Institute for Psychology, University of Basel, Basel, Switzerland. tanja.michael@unibas.ch
Blechert J
No affiliation info available
Vriends N
No affiliation info available
Margraf J
No affiliation info available
Wilhelm FH
No affiliation info available

MeSH

AdolescentAdultAgedAttitudeConditioning, ClassicalExtinction, PsychologicalFearFemaleHumansMaleMiddle AgedPanic Disorder

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17696717

Citation

Michael, Tanja, et al. "Fear Conditioning in Panic Disorder: Enhanced Resistance to Extinction." Journal of Abnormal Psychology, vol. 116, no. 3, 2007, pp. 612-7.
Michael T, Blechert J, Vriends N, et al. Fear conditioning in panic disorder: Enhanced resistance to extinction. J Abnorm Psychol. 2007;116(3):612-7.
Michael, T., Blechert, J., Vriends, N., Margraf, J., & Wilhelm, F. H. (2007). Fear conditioning in panic disorder: Enhanced resistance to extinction. Journal of Abnormal Psychology, 116(3), 612-7.
Michael T, et al. Fear Conditioning in Panic Disorder: Enhanced Resistance to Extinction. J Abnorm Psychol. 2007;116(3):612-7. PubMed PMID: 17696717.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fear conditioning in panic disorder: Enhanced resistance to extinction. AU - Michael,Tanja, AU - Blechert,Jens, AU - Vriends,Noortje, AU - Margraf,Jürgen, AU - Wilhelm,Frank H, PY - 2007/8/19/pubmed PY - 2007/10/2/medline PY - 2007/8/19/entrez SP - 612 EP - 7 JF - Journal of abnormal psychology JO - J Abnorm Psychol VL - 116 IS - 3 N2 - Enhanced conditionability has been proposed as a crucial factor in the etiology and maintenance of panic disorder (PD). To test this assumption, the authors of the current study examined the acquisition and extinction of conditioned responses to aversive stimuli in PD. Thirty-nine PD patients and 33 healthy control participants took part in a differential aversive conditioning experiment. A highly annoying but not painful electrical stimulus served as the unconditioned stimulus (US), and two neutral pictures were used as either the paired conditioned stimulus (CS+) or the unpaired conditioned stimulus (CS-). Results indicate that PD patients do not show larger conditioned responses during acquisition than control participants. However, in contrast to control participants, PD patients exhibited larger skin conductance responses to CS+ stimuli during extinction and maintained a more negative evaluation of them, as indicated by valence ratings obtained several times throughout the experiment. This suggests that PD patients show enhanced conditionability with respect to extinction. SN - 0021-843X UR - https://www.unboundmedicine.com/medline/citation/17696717/Fear_conditioning_in_panic_disorder:_Enhanced_resistance_to_extinction_ L2 - http://content.apa.org/journals/abn/116/3/612 DB - PRIME DP - Unbound Medicine ER -