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Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis.
Thyroid 2007; 17(7):609-12T

Abstract

OBJECTIVE

We studied the effects of selenium (Se) treatment on serum anti-thyroid peroxidase (TPO) levels in Greek patients with Hashimoto's thyroiditis (HT).

DESIGN

We prospectively studied 80 women with HT, median age 37 (range 24-52) years, for 1 year. All patients received 200 microg Se in the form of l-selenomethionine orally for 6 months. At the end of the 6-month period, 40 patients continued taking 200 microg Se (Group A) and 40 patients stopped (Group B). Serum thyrotropin (TSH), free triiodothyronine (FT(3)), free thyroxine (FT(4)), anti-TPO, and anti-thyroglobulin (Tg) levels were measured at baseline and at the end of each 3-month period.

MAIN OUTCOME

There was a significant reduction of serum anti-TPO levels during the first 6 months (by 5.6% and 9.9% at 3 and 6 months, respectively). An overall reduction of 21% (p < 0.0001) compared with the basal values was noted in Group A. In Group B, serum anti-TPO levels were increased by 4.8% (p < 0.0001) during the second 6-month period.

CONCLUSIONS

Our study showed that in HT patients 6 months of Se treatment caused a significant decrease in serum anti-TPO levels, which was more profound in the second trimester. The extension of Se supplementation for 6 more months resulted in an additional 8% decrease, while the cessation caused a 4.8% increase, in the anti-TPO concentrations.

Authors+Show Affiliations

Department of Internal Medicine, University Hospital of Heraklion, Crete, Greece. elmazokopakis@yahoo.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

17696828

Citation

Mazokopakis, Elias E., et al. "Effects of 12 Months Treatment With L-selenomethionine On Serum anti-TPO Levels in Patients With Hashimoto's Thyroiditis." Thyroid : Official Journal of the American Thyroid Association, vol. 17, no. 7, 2007, pp. 609-12.
Mazokopakis EE, Papadakis JA, Papadomanolaki MG, et al. Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis. Thyroid. 2007;17(7):609-12.
Mazokopakis, E. E., Papadakis, J. A., Papadomanolaki, M. G., Batistakis, A. G., Giannakopoulos, T. G., Protopapadakis, E. E., & Ganotakis, E. S. (2007). Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis. Thyroid : Official Journal of the American Thyroid Association, 17(7), pp. 609-12.
Mazokopakis EE, et al. Effects of 12 Months Treatment With L-selenomethionine On Serum anti-TPO Levels in Patients With Hashimoto's Thyroiditis. Thyroid. 2007;17(7):609-12. PubMed PMID: 17696828.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of 12 months treatment with L-selenomethionine on serum anti-TPO Levels in Patients with Hashimoto's thyroiditis. AU - Mazokopakis,Elias E, AU - Papadakis,John A, AU - Papadomanolaki,Maria G, AU - Batistakis,Antony G, AU - Giannakopoulos,Triantafillos G, AU - Protopapadakis,Eftichios E, AU - Ganotakis,Emmanuel S, PY - 2007/8/19/pubmed PY - 2007/10/5/medline PY - 2007/8/19/entrez SP - 609 EP - 12 JF - Thyroid : official journal of the American Thyroid Association JO - Thyroid VL - 17 IS - 7 N2 - OBJECTIVE: We studied the effects of selenium (Se) treatment on serum anti-thyroid peroxidase (TPO) levels in Greek patients with Hashimoto's thyroiditis (HT). DESIGN: We prospectively studied 80 women with HT, median age 37 (range 24-52) years, for 1 year. All patients received 200 microg Se in the form of l-selenomethionine orally for 6 months. At the end of the 6-month period, 40 patients continued taking 200 microg Se (Group A) and 40 patients stopped (Group B). Serum thyrotropin (TSH), free triiodothyronine (FT(3)), free thyroxine (FT(4)), anti-TPO, and anti-thyroglobulin (Tg) levels were measured at baseline and at the end of each 3-month period. MAIN OUTCOME: There was a significant reduction of serum anti-TPO levels during the first 6 months (by 5.6% and 9.9% at 3 and 6 months, respectively). An overall reduction of 21% (p < 0.0001) compared with the basal values was noted in Group A. In Group B, serum anti-TPO levels were increased by 4.8% (p < 0.0001) during the second 6-month period. CONCLUSIONS: Our study showed that in HT patients 6 months of Se treatment caused a significant decrease in serum anti-TPO levels, which was more profound in the second trimester. The extension of Se supplementation for 6 more months resulted in an additional 8% decrease, while the cessation caused a 4.8% increase, in the anti-TPO concentrations. SN - 1050-7256 UR - https://www.unboundmedicine.com/medline/citation/17696828/Effects_of_12_months_treatment_with_L_selenomethionine_on_serum_anti_TPO_Levels_in_Patients_with_Hashimoto's_thyroiditis_ L2 - https://www.liebertpub.com/doi/full/10.1089/thy.2007.0040?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -