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Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases.
APMIS. 2007 Aug; 115(8):969-75.A

Abstract

Microarray studies have shown that matrilysin or matrix metalloproteinase (MMP)-7 is highly upregulated in the lungs of patients with idiopathic pulmonary fibrosis (IPF), but MMP-7 protein expression has not been systematically compared between IPF and other interstitial lung diseases. MMP-7 levels in bronchoalveolar lavage fluid (BALF) were compared to corresponding samples from nonspecific interstitial pneumonia (NSIP), sarcoidosis, and healthy controls. MMP-7 levels in the BALF were determined by ELISA and localization of MMP-7 in the lung tissue by immunohistochemistry. MMP-7 was similarly elevated in the BALF of all these disorders compared to healthy controls (p=0.007). Even control subjects with prolonged cough displayed a tendency towards elevated MMP-7 expression. There was a negative correlation between BALF MMP-7 levels and forced expiratory vital capacity (r=-0.348, p=0.02, n=42). In IPF lung, MMP-7 immunoreactivity appeared predominantly in the fibrotic parenchyma and arterial wall. In sarcoidosis and NSIP, prominent MMP-7 immunoreactivity was found in areas of inflammation. These results demonstrate that elevated BALF MMP-7 is not restricted to IPF alone but is also observed in other interstitial lung diseases and cannot be used as a differential diagnostic marker for IPF.

Authors+Show Affiliations

Department of Medicine and Division of Pulmonary Medicine, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17696954

Citation

Vuorinen, Kirsi, et al. "Elevated Matrilysin Levels in Bronchoalveolar Lavage Fluid Do Not Distinguish Idiopathic Pulmonary Fibrosis From Other Interstitial Lung Diseases." APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, vol. 115, no. 8, 2007, pp. 969-75.
Vuorinen K, Myllärniemi M, Lammi L, et al. Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases. APMIS. 2007;115(8):969-75.
Vuorinen, K., Myllärniemi, M., Lammi, L., Piirilä, P., Rytilä, P., Salmenkivi, K., & Kinnula, V. L. (2007). Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases. APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica, 115(8), 969-75.
Vuorinen K, et al. Elevated Matrilysin Levels in Bronchoalveolar Lavage Fluid Do Not Distinguish Idiopathic Pulmonary Fibrosis From Other Interstitial Lung Diseases. APMIS. 2007;115(8):969-75. PubMed PMID: 17696954.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevated matrilysin levels in bronchoalveolar lavage fluid do not distinguish idiopathic pulmonary fibrosis from other interstitial lung diseases. AU - Vuorinen,Kirsi, AU - Myllärniemi,Marjukka, AU - Lammi,Lauri, AU - Piirilä,Päivi, AU - Rytilä,Paula, AU - Salmenkivi,Kaisa, AU - Kinnula,Vuokko L, PY - 2007/8/19/pubmed PY - 2007/9/21/medline PY - 2007/8/19/entrez SP - 969 EP - 75 JF - APMIS : acta pathologica, microbiologica, et immunologica Scandinavica JO - APMIS VL - 115 IS - 8 N2 - Microarray studies have shown that matrilysin or matrix metalloproteinase (MMP)-7 is highly upregulated in the lungs of patients with idiopathic pulmonary fibrosis (IPF), but MMP-7 protein expression has not been systematically compared between IPF and other interstitial lung diseases. MMP-7 levels in bronchoalveolar lavage fluid (BALF) were compared to corresponding samples from nonspecific interstitial pneumonia (NSIP), sarcoidosis, and healthy controls. MMP-7 levels in the BALF were determined by ELISA and localization of MMP-7 in the lung tissue by immunohistochemistry. MMP-7 was similarly elevated in the BALF of all these disorders compared to healthy controls (p=0.007). Even control subjects with prolonged cough displayed a tendency towards elevated MMP-7 expression. There was a negative correlation between BALF MMP-7 levels and forced expiratory vital capacity (r=-0.348, p=0.02, n=42). In IPF lung, MMP-7 immunoreactivity appeared predominantly in the fibrotic parenchyma and arterial wall. In sarcoidosis and NSIP, prominent MMP-7 immunoreactivity was found in areas of inflammation. These results demonstrate that elevated BALF MMP-7 is not restricted to IPF alone but is also observed in other interstitial lung diseases and cannot be used as a differential diagnostic marker for IPF. SN - 0903-4641 UR - https://www.unboundmedicine.com/medline/citation/17696954/Elevated_matrilysin_levels_in_bronchoalveolar_lavage_fluid_do_not_distinguish_idiopathic_pulmonary_fibrosis_from_other_interstitial_lung_diseases_ L2 - https://doi.org/10.1111/j.1600-0463.2007.apm_697.x DB - PRIME DP - Unbound Medicine ER -