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Long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma.
Vaccine. 2007 Sep 17; 25(37-38):6692-8.V

Abstract

To evaluate long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma, a prospective study was conducted during 2005-2006 influenza season in six public pediatric clinics in Milan and surroundings, Northern Italy. A single dose (0.5 ml) of a virosomal subunit inactivated influenza vaccine (Inflexal V) was injected in 106 asthmatic children aged 3-9 years. Serum hemagglutinin inhibition antibody titers were determined against the recommended influenza strains A/New Caledonia (H1N1), A/California (H3N2), and B/Shanghai (B), at pre-vaccination and 1 and 6 months after vaccination. Seroconversion rate (95% CI) against the strains A/H1N1, A/H3N2 and B was, respectively, 78% (68.6-85.7), 57% (46.7-66.9) and 66% (55.8-71.2) at 1 month. Seroprotection (titer> or =40) rate for A/H1N1, A/H3N2 and B was, respectively, 87% (77.8-92.2), 82% (72.6-89.7) and 90% (82.6-94.8) at 1 month and 74% (64.3-82.3), 77% (67.5-84.8), and 77% (67.5-84.8) at 6 months. Seroprotection rate was high and persistent (>95%) in children with pre-existing antibodies (titer> or =10) at pre-vaccination for any specific strain. In children without pre-existing antibodies, seroprotection rate for A/H1N1, A/H3N2 and B was, respectively, 67.6%, 66.7% and 74.4% at 1 month, and 35.1%, 56.2% and 41.0% at 6 months after vaccination. Vaccine was well tolerated. These results indicate that in unvaccinated children with asthma vaccination with a single dose of virosomal-adjuvanted influenza vaccine is well tolerated and effective as a whole. However, while immunity response and persistence are excellently high in children with pre-existing antibodies, in children naive for the antigens the immune parameters are lower at 6 months after vaccination.

Authors+Show Affiliations

Zuccotti G
Department of Pediatrics, University of Milan, Luigi Sacco Hospital, Via GB Grassi 74, 20157 Milan, Italy. gianvincenzo.zuccotti@unimi.it
Amendola A
No affiliation info available
Viganò A
No affiliation info available
Pariani E
No affiliation info available
Zappa A
No affiliation info available
Pogliani L
No affiliation info available
Giacomet V
No affiliation info available
Savarino A
No affiliation info available
Podestà A
No affiliation info available
Rottoli A
No affiliation info available
Tanzi E
No affiliation info available
Zanetti A
No affiliation info available
Radaelli G
No affiliation info available

MeSH

Acute DiseaseAntibodies, ViralAsthmaChildChild, PreschoolHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInfluenza B virusInfluenza VaccinesProspective StudiesTime FactorsTreatment OutcomeVaccines, InactivatedVaccines, SubunitVirosomes

Pub Type(s)

Journal Article
Multicenter Study

Language

eng

PubMed ID

17697730

Citation

Zuccotti, Gianvincenzo, et al. "Long-term Immunogenicity of a Virosomal Subunit Inactivated Influenza Vaccine in Children With Asthma." Vaccine, vol. 25, no. 37-38, 2007, pp. 6692-8.
Zuccotti G, Amendola A, Viganò A, et al. Long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma. Vaccine. 2007;25(37-38):6692-8.
Zuccotti, G., Amendola, A., Viganò, A., Pariani, E., Zappa, A., Pogliani, L., Giacomet, V., Savarino, A., Podestà, A., Rottoli, A., Tanzi, E., Zanetti, A., & Radaelli, G. (2007). Long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma. Vaccine, 25(37-38), 6692-8.
Zuccotti G, et al. Long-term Immunogenicity of a Virosomal Subunit Inactivated Influenza Vaccine in Children With Asthma. Vaccine. 2007 Sep 17;25(37-38):6692-8. PubMed PMID: 17697730.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma. AU - Zuccotti,Gianvincenzo, AU - Amendola,Antonella, AU - Viganò,Alessandra, AU - Pariani,Elena, AU - Zappa,Alessandra, AU - Pogliani,Laura, AU - Giacomet,Vania, AU - Savarino,Antonino, AU - Podestà,Alberto, AU - Rottoli,Amilcare, AU - Tanzi,Elisabetta, AU - Zanetti,Alessandro, AU - Radaelli,Giovanni, Y1 - 2007/07/27/ PY - 2006/12/27/received PY - 2007/06/04/revised PY - 2007/07/10/accepted PY - 2007/8/19/pubmed PY - 2007/11/9/medline PY - 2007/8/19/entrez SP - 6692 EP - 8 JF - Vaccine JO - Vaccine VL - 25 IS - 37-38 N2 - To evaluate long-term immunogenicity of a virosomal subunit inactivated influenza vaccine in children with asthma, a prospective study was conducted during 2005-2006 influenza season in six public pediatric clinics in Milan and surroundings, Northern Italy. A single dose (0.5 ml) of a virosomal subunit inactivated influenza vaccine (Inflexal V) was injected in 106 asthmatic children aged 3-9 years. Serum hemagglutinin inhibition antibody titers were determined against the recommended influenza strains A/New Caledonia (H1N1), A/California (H3N2), and B/Shanghai (B), at pre-vaccination and 1 and 6 months after vaccination. Seroconversion rate (95% CI) against the strains A/H1N1, A/H3N2 and B was, respectively, 78% (68.6-85.7), 57% (46.7-66.9) and 66% (55.8-71.2) at 1 month. Seroprotection (titer> or =40) rate for A/H1N1, A/H3N2 and B was, respectively, 87% (77.8-92.2), 82% (72.6-89.7) and 90% (82.6-94.8) at 1 month and 74% (64.3-82.3), 77% (67.5-84.8), and 77% (67.5-84.8) at 6 months. Seroprotection rate was high and persistent (>95%) in children with pre-existing antibodies (titer> or =10) at pre-vaccination for any specific strain. In children without pre-existing antibodies, seroprotection rate for A/H1N1, A/H3N2 and B was, respectively, 67.6%, 66.7% and 74.4% at 1 month, and 35.1%, 56.2% and 41.0% at 6 months after vaccination. Vaccine was well tolerated. These results indicate that in unvaccinated children with asthma vaccination with a single dose of virosomal-adjuvanted influenza vaccine is well tolerated and effective as a whole. However, while immunity response and persistence are excellently high in children with pre-existing antibodies, in children naive for the antigens the immune parameters are lower at 6 months after vaccination. SN - 0264-410X UR - https://www.unboundmedicine.com/medline/citation/17697730/Long_term_immunogenicity_of_a_virosomal_subunit_inactivated_influenza_vaccine_in_children_with_asthma_ DB - PRIME DP - Unbound Medicine ER -