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Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline.
Am J Cardiol. 2007 Aug 15; 100(4):563-8.AJ

Abstract

The magnitude of work an individual is able to perform at the heart rate (HR) of 100 beats/min (WL(100)) is a simple, integrated measure of HR at rest, HR response to light dynamic exercise, as well as cardiorespiratory performance. Because a high HR at rest and a low cardiorespiratory performance are previously established risk factors for cardiovascular disease (CVD) mortality, it can be deduced that WL(100) is a potential predictor of CVD and coronary heart disease (CHD) mortality. The aim of the present study was to investigate whether WL(100) independently predicts CVD and CHD mortality in middle-aged men. The subjects were a representative sample of 1,314 middle-aged men who did not have CHD and did not use HR-lowering medication at baseline. The association of WL(100) with CVD and CHD mortality was examined by Cox regression models with backward stepwise selection, including numerous known risk factors for CVD death. During an average follow-up of 11.5 years, there were 51 CVD deaths, of which 35 were due to CHD. In Cox multivariable models, CVD mortality increased by 72% (95% confidence interval 27% to 138%, p = 0.001) and CHD mortality by 89% (95% confidence interval 28% to 178%, p = 0.001) with 1 SD (31 W) decrement in WL(100). WL(100) improved the predictive power of the adjusted Cox models, including other HR-derived and exercise test variables. In conclusion, WL(100) predicts CVD and CHD mortality in men without previous CHD. The association of WL(100) with CVD and CHD mortality is not explained by maximal cardiorespiratory performance.

Authors+Show Affiliations

Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. savonen@hytti.uku.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17697806

Citation

Savonen, Kai P., et al. "Effectiveness of Workload at the Heart Rate of 100 Beats/min in Predicting Cardiovascular Mortality in Men Aged 42, 48, 54, or 60 Years at Baseline." The American Journal of Cardiology, vol. 100, no. 4, 2007, pp. 563-8.
Savonen KP, Lakka TA, Laukkanen JA, et al. Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline. Am J Cardiol. 2007;100(4):563-8.
Savonen, K. P., Lakka, T. A., Laukkanen, J. A., Rauramaa, T. H., Salonen, J. T., & Rauramaa, R. (2007). Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline. The American Journal of Cardiology, 100(4), 563-8.
Savonen KP, et al. Effectiveness of Workload at the Heart Rate of 100 Beats/min in Predicting Cardiovascular Mortality in Men Aged 42, 48, 54, or 60 Years at Baseline. Am J Cardiol. 2007 Aug 15;100(4):563-8. PubMed PMID: 17697806.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effectiveness of workload at the heart rate of 100 beats/min in predicting cardiovascular mortality in men aged 42, 48, 54, or 60 years at baseline. AU - Savonen,Kai P, AU - Lakka,Timo A, AU - Laukkanen,Jari A, AU - Rauramaa,Tuomas H, AU - Salonen,Jukka T, AU - Rauramaa,Rainer, Y1 - 2007/06/28/ PY - 2007/01/26/received PY - 2007/03/09/revised PY - 2007/03/09/accepted PY - 2007/8/19/pubmed PY - 2007/9/28/medline PY - 2007/8/19/entrez SP - 563 EP - 8 JF - The American journal of cardiology JO - Am J Cardiol VL - 100 IS - 4 N2 - The magnitude of work an individual is able to perform at the heart rate (HR) of 100 beats/min (WL(100)) is a simple, integrated measure of HR at rest, HR response to light dynamic exercise, as well as cardiorespiratory performance. Because a high HR at rest and a low cardiorespiratory performance are previously established risk factors for cardiovascular disease (CVD) mortality, it can be deduced that WL(100) is a potential predictor of CVD and coronary heart disease (CHD) mortality. The aim of the present study was to investigate whether WL(100) independently predicts CVD and CHD mortality in middle-aged men. The subjects were a representative sample of 1,314 middle-aged men who did not have CHD and did not use HR-lowering medication at baseline. The association of WL(100) with CVD and CHD mortality was examined by Cox regression models with backward stepwise selection, including numerous known risk factors for CVD death. During an average follow-up of 11.5 years, there were 51 CVD deaths, of which 35 were due to CHD. In Cox multivariable models, CVD mortality increased by 72% (95% confidence interval 27% to 138%, p = 0.001) and CHD mortality by 89% (95% confidence interval 28% to 178%, p = 0.001) with 1 SD (31 W) decrement in WL(100). WL(100) improved the predictive power of the adjusted Cox models, including other HR-derived and exercise test variables. In conclusion, WL(100) predicts CVD and CHD mortality in men without previous CHD. The association of WL(100) with CVD and CHD mortality is not explained by maximal cardiorespiratory performance. SN - 0002-9149 UR - https://www.unboundmedicine.com/medline/citation/17697806/Effectiveness_of_workload_at_the_heart_rate_of_100_beats/min_in_predicting_cardiovascular_mortality_in_men_aged_42_48_54_or_60_years_at_baseline_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9149(07)00858-2 DB - PRIME DP - Unbound Medicine ER -