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Association between serum testosterone concentration and collagen degradation fragments in men with type 2 diabetes mellitus.
Metabolism. 2007 Sep; 56(9):1228-32.M

Abstract

The aim of the present study was to evaluate relationships between serum endogenous androgens and urinary concentration of cross-linked N-telopeptides of type I collagen (NTx), a bone resorption marker, in men with type 2 diabetes mellitus because low androgen concentrations are associated with both osteoporosis and cardiovascular disease. Relationships between serum free testosterone and urinary NTx concentrations were investigated in 246 consecutive men with type 2 diabetes mellitus. In addition, relationships between urinary NTx concentration and other variables including age, duration of diabetes, blood pressure, serum lipid concentration, hemoglobin A(1c), and body mass index were evaluated. Urinary NTx concentrations were 27.8 (26.4-29.3) nmol of bone collagen equivalent per millimole of creatinine, correlating inversely with serum free testosterone (r = -0.263, P < .0001). Multiple regression analysis identified serum free testosterone (beta = -.292, P < .0001), hemoglobin A(1c) (beta = .144, P = .0404), and smoking status (beta = .143, P = .0402) as independent determinants of urinary NTx. In conclusion, serum free testosterone concentration correlated inversely with urinary NTx concentration, which may partly account for an observed link between osteoporosis and cardiovascular disease in men with type 2 diabetes mellitus.

Authors+Show Affiliations

Department of Endocrinology and Metabolism, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. sayarinapm@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17697866

Citation

Fukui, Michiaki, et al. "Association Between Serum Testosterone Concentration and Collagen Degradation Fragments in Men With Type 2 Diabetes Mellitus." Metabolism: Clinical and Experimental, vol. 56, no. 9, 2007, pp. 1228-32.
Fukui M, Ose H, Nakayama I, et al. Association between serum testosterone concentration and collagen degradation fragments in men with type 2 diabetes mellitus. Metab Clin Exp. 2007;56(9):1228-32.
Fukui, M., Ose, H., Nakayama, I., Hosoda, H., Asano, M., Kadono, M., Mogami, S., Yamazaki, M., Hasegawa, G., Yoshikawa, T., & Nakamura, N. (2007). Association between serum testosterone concentration and collagen degradation fragments in men with type 2 diabetes mellitus. Metabolism: Clinical and Experimental, 56(9), 1228-32.
Fukui M, et al. Association Between Serum Testosterone Concentration and Collagen Degradation Fragments in Men With Type 2 Diabetes Mellitus. Metab Clin Exp. 2007;56(9):1228-32. PubMed PMID: 17697866.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum testosterone concentration and collagen degradation fragments in men with type 2 diabetes mellitus. AU - Fukui,Michiaki, AU - Ose,Hiroyuki, AU - Nakayama,Ichiko, AU - Hosoda,Hiroko, AU - Asano,Mai, AU - Kadono,Mayuko, AU - Mogami,Shin-Ichi, AU - Yamazaki,Masahiro, AU - Hasegawa,Goji, AU - Yoshikawa,Toshikazu, AU - Nakamura,Naoto, PY - 2006/12/22/received PY - 2007/04/04/accepted PY - 2007/8/19/pubmed PY - 2007/10/10/medline PY - 2007/8/19/entrez SP - 1228 EP - 32 JF - Metabolism: clinical and experimental JO - Metab. Clin. Exp. VL - 56 IS - 9 N2 - The aim of the present study was to evaluate relationships between serum endogenous androgens and urinary concentration of cross-linked N-telopeptides of type I collagen (NTx), a bone resorption marker, in men with type 2 diabetes mellitus because low androgen concentrations are associated with both osteoporosis and cardiovascular disease. Relationships between serum free testosterone and urinary NTx concentrations were investigated in 246 consecutive men with type 2 diabetes mellitus. In addition, relationships between urinary NTx concentration and other variables including age, duration of diabetes, blood pressure, serum lipid concentration, hemoglobin A(1c), and body mass index were evaluated. Urinary NTx concentrations were 27.8 (26.4-29.3) nmol of bone collagen equivalent per millimole of creatinine, correlating inversely with serum free testosterone (r = -0.263, P < .0001). Multiple regression analysis identified serum free testosterone (beta = -.292, P < .0001), hemoglobin A(1c) (beta = .144, P = .0404), and smoking status (beta = .143, P = .0402) as independent determinants of urinary NTx. In conclusion, serum free testosterone concentration correlated inversely with urinary NTx concentration, which may partly account for an observed link between osteoporosis and cardiovascular disease in men with type 2 diabetes mellitus. SN - 0026-0495 UR - https://www.unboundmedicine.com/medline/citation/17697866/Association_between_serum_testosterone_concentration_and_collagen_degradation_fragments_in_men_with_type_2_diabetes_mellitus_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0026-0495(07)00157-6 DB - PRIME DP - Unbound Medicine ER -