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Five-year colon surveillance after screening colonoscopy.
Gastroenterology. 2007 Oct; 133(4):1077-85.G

Abstract

BACKGROUND & AIMS

Outcomes of colon surveillance after colorectal cancer screening with colonoscopy are uncertain. We conducted a prospective study to measure incidence of advanced neoplasia in patients within 5.5 years of screening colonoscopy.

METHODS

Three thousand one hundred twenty-one asymptomatic subjects, age 50 to 75 years, had screening colonoscopy between 1994 and 1997 in the Department of Veterans Affairs. One thousand one hundred seventy-one subjects with neoplasia and 501 neoplasia-free controls were assigned to colonoscopic surveillance over 5 years. Cohorts were defined by baseline findings. Relative risks for advanced neoplasia within 5.5 years were calculated. Advanced neoplasia was defined as tubular adenoma greater than > or =10 mm, adenoma with villous histology, adenoma with high-grade dysplasia, or invasive cancer.

RESULTS

Eight hundred ninety-five (76.4%) patients with neoplasia and 298 subjects (59.5%) without neoplasia at baseline had colonoscopy within 5.5 years; 2.4% of patients with no neoplasia had interval advanced neoplasia. The relative risk in patients with baseline neoplasia was 1.92 (95% CI: 0.83-4.42) with 1 or 2 tubular adenomas <10 mm, 5.01 (95% CI: 2.10-11.96) with 3 or more tubular adenomas <10 mm, 6.40 (95% CI: 2.74-14.94) with tubular adenoma > or =10 mm, 6.05 (95% CI: 2.48-14.71) for villous adenoma, and 6.87 (95% CI: 2.61-18.07) for adenoma with high-grade dysplasia.

CONCLUSIONS

There is a strong association between results of baseline screening colonoscopy and rate of serious incident lesions during 5.5 years of surveillance. Patients with 1 or 2 tubular adenomas less than 10 mm represent a low-risk group compared with other patients with colon neoplasia.

Authors+Show Affiliations

Department of Veterans Affairs Medical Center, Portland, Oregon 97239, USA. lieberma@ohsu.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Randomized Controlled Trial
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

17698067

Citation

Lieberman, David A., et al. "Five-year Colon Surveillance After Screening Colonoscopy." Gastroenterology, vol. 133, no. 4, 2007, pp. 1077-85.
Lieberman DA, Weiss DG, Harford WV, et al. Five-year colon surveillance after screening colonoscopy. Gastroenterology. 2007;133(4):1077-85.
Lieberman, D. A., Weiss, D. G., Harford, W. V., Ahnen, D. J., Provenzale, D., Sontag, S. J., Schnell, T. G., Chejfec, G., Campbell, D. R., Kidao, J., Bond, J. H., Nelson, D. B., Triadafilopoulos, G., Ramirez, F. C., Collins, J. F., Johnston, T. K., McQuaid, K. R., Garewal, H., Sampliner, R. E., ... Robertson, D. (2007). Five-year colon surveillance after screening colonoscopy. Gastroenterology, 133(4), 1077-85.
Lieberman DA, et al. Five-year Colon Surveillance After Screening Colonoscopy. Gastroenterology. 2007;133(4):1077-85. PubMed PMID: 17698067.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Five-year colon surveillance after screening colonoscopy. AU - Lieberman,David A, AU - Weiss,David G, AU - Harford,William V, AU - Ahnen,Dennis J, AU - Provenzale,Dawn, AU - Sontag,Stephen J, AU - Schnell,Thomas G, AU - Chejfec,Gregorio, AU - Campbell,Donald R, AU - Kidao,Jayashri, AU - Bond,John H, AU - Nelson,Douglas B, AU - Triadafilopoulos,George, AU - Ramirez,Francisco C, AU - Collins,Judith F, AU - Johnston,Tiina K, AU - McQuaid,Kenneth R, AU - Garewal,Harinder, AU - Sampliner,Richard E, AU - Esquivel,Romeo, AU - Robertson,Douglas, PY - 2007/01/22/received PY - 2007/06/14/accepted PY - 2007/8/19/pubmed PY - 2007/10/27/medline PY - 2007/8/19/entrez SP - 1077 EP - 85 JF - Gastroenterology JO - Gastroenterology VL - 133 IS - 4 N2 - BACKGROUND & AIMS: Outcomes of colon surveillance after colorectal cancer screening with colonoscopy are uncertain. We conducted a prospective study to measure incidence of advanced neoplasia in patients within 5.5 years of screening colonoscopy. METHODS: Three thousand one hundred twenty-one asymptomatic subjects, age 50 to 75 years, had screening colonoscopy between 1994 and 1997 in the Department of Veterans Affairs. One thousand one hundred seventy-one subjects with neoplasia and 501 neoplasia-free controls were assigned to colonoscopic surveillance over 5 years. Cohorts were defined by baseline findings. Relative risks for advanced neoplasia within 5.5 years were calculated. Advanced neoplasia was defined as tubular adenoma greater than > or =10 mm, adenoma with villous histology, adenoma with high-grade dysplasia, or invasive cancer. RESULTS: Eight hundred ninety-five (76.4%) patients with neoplasia and 298 subjects (59.5%) without neoplasia at baseline had colonoscopy within 5.5 years; 2.4% of patients with no neoplasia had interval advanced neoplasia. The relative risk in patients with baseline neoplasia was 1.92 (95% CI: 0.83-4.42) with 1 or 2 tubular adenomas <10 mm, 5.01 (95% CI: 2.10-11.96) with 3 or more tubular adenomas <10 mm, 6.40 (95% CI: 2.74-14.94) with tubular adenoma > or =10 mm, 6.05 (95% CI: 2.48-14.71) for villous adenoma, and 6.87 (95% CI: 2.61-18.07) for adenoma with high-grade dysplasia. CONCLUSIONS: There is a strong association between results of baseline screening colonoscopy and rate of serious incident lesions during 5.5 years of surveillance. Patients with 1 or 2 tubular adenomas less than 10 mm represent a low-risk group compared with other patients with colon neoplasia. SN - 0016-5085 UR - https://www.unboundmedicine.com/medline/citation/17698067/Five_year_colon_surveillance_after_screening_colonoscopy_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0016-5085(07)01306-6 DB - PRIME DP - Unbound Medicine ER -