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Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose.
Pharmacol Biochem Behav. 2007 Nov; 88(1):64-72.PB

Abstract

The neuroprotective effects of catalpol, an iridoid glycoside isolated from the fresh Rehmannia roots, on the senescent mice induced by D-galactose were assessed. The mice subcutaneously injected with catalpol (5 or 10 mg/kg, 2 weeks, from fifth week) showed significantly improved learning and memory ability in Morris water maze test compared with d-galactose treated mice (150 mg/kg, 6 weeks). We further investigated the mechanism involved in the neuroprotective effects of catalpol on the mice brain tissue. The results showed that catalpol increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), decreased the malondialdehyde (MDA) level, elevated the activities of Na+ -K+ ATPase and Ca2+ -Mg2+ ATPase on the cerebral cortex and hippocampus of d-galactose treated mouse. All the data suggested that catalpol had the potential to be a useful cognitive impairment treatment, and its beneficial effects may be partly mediated via enhancing endogenous antioxidant enzymatic activities and inhibiting free radical generation.

Authors+Show Affiliations

School of Environmental and Biological Science & Technology, Dalian University of Technology, Dalian, 116024, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17698178

Citation

Zhang, Xiu Li, et al. "Catalpol Ameliorates Cognition Deficits and Attenuates Oxidative Damage in the Brain of Senescent Mice Induced By D-galactose." Pharmacology, Biochemistry, and Behavior, vol. 88, no. 1, 2007, pp. 64-72.
Zhang XL, Jiang B, Li ZB, et al. Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Pharmacol Biochem Behav. 2007;88(1):64-72.
Zhang, X. L., Jiang, B., Li, Z. B., Hao, S., & An, L. J. (2007). Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. Pharmacology, Biochemistry, and Behavior, 88(1), 64-72.
Zhang XL, et al. Catalpol Ameliorates Cognition Deficits and Attenuates Oxidative Damage in the Brain of Senescent Mice Induced By D-galactose. Pharmacol Biochem Behav. 2007;88(1):64-72. PubMed PMID: 17698178.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Catalpol ameliorates cognition deficits and attenuates oxidative damage in the brain of senescent mice induced by D-galactose. AU - Zhang,Xiu Li, AU - Jiang,Bo, AU - Li,Zhi Bo, AU - Hao,Shuang, AU - An,Li Jia, Y1 - 2007/07/18/ PY - 2007/01/22/received PY - 2007/06/19/revised PY - 2007/07/04/accepted PY - 2007/8/19/pubmed PY - 2007/11/6/medline PY - 2007/8/19/entrez SP - 64 EP - 72 JF - Pharmacology, biochemistry, and behavior JO - Pharmacol Biochem Behav VL - 88 IS - 1 N2 - The neuroprotective effects of catalpol, an iridoid glycoside isolated from the fresh Rehmannia roots, on the senescent mice induced by D-galactose were assessed. The mice subcutaneously injected with catalpol (5 or 10 mg/kg, 2 weeks, from fifth week) showed significantly improved learning and memory ability in Morris water maze test compared with d-galactose treated mice (150 mg/kg, 6 weeks). We further investigated the mechanism involved in the neuroprotective effects of catalpol on the mice brain tissue. The results showed that catalpol increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), decreased the malondialdehyde (MDA) level, elevated the activities of Na+ -K+ ATPase and Ca2+ -Mg2+ ATPase on the cerebral cortex and hippocampus of d-galactose treated mouse. All the data suggested that catalpol had the potential to be a useful cognitive impairment treatment, and its beneficial effects may be partly mediated via enhancing endogenous antioxidant enzymatic activities and inhibiting free radical generation. SN - 0091-3057 UR - https://www.unboundmedicine.com/medline/citation/17698178/Catalpol_ameliorates_cognition_deficits_and_attenuates_oxidative_damage_in_the_brain_of_senescent_mice_induced_by_D_galactose_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0091-3057(07)00216-X DB - PRIME DP - Unbound Medicine ER -