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Correlation between omental TNF-alpha protein and plasma PAI-1 in obesity subjects.
Int J Cardiol 2008; 128(3):399-405IJ

Abstract

BACKGROUND

The role of TNF-alpha in contributing to obesity-associated cardiovascular and metabolic risk has gained much attention.

MATERIALS AND METHODS

Paired biopsies of omental and subcutaneous fat were collected from 16 lean subjects and 32 central obesity subjects. The expression of TNF-alpha in omental and subcutaneous fat was quantified by western blotting method, and correlations with plasma PAI-1, homeostasis model assessment insulin resistance (HOMA-IR), and lipid were investigated.

RESULTS

In obese female, TNF-alpha expression was higher in the omental than in the subcutaneous fat tissue. There was no significant difference in the levels of TNF-alpha between subcutaneous and visceral fat in obese male. Significant positive correlations were found between omental TNF-alpha protein and plasma PAI-1 levels in obesity. In obese female subjects, omental TNF-alpha protein levels showed a close association with most of the parameters studied: fasting glucose (r=0.541, P<0.05); fasting insulin (r=0.599, P<0.01); HOMA-IR (r=0.546, P<0.05); triglycerides (r=0.469, P<0.05); HDL-cholesterol (r=-0.759, P<0.01). In obese male population, correlations between omental TNF-alpha protein levels and fasting glucose (r=0.762, P<0.01); fasting insulin (r=0.622, P<0.05); triglycerides (r=0.650, P<0.05); HDL-cholesterol (r=-0.880, P<0.01) were found.

CONCLUSION

Omental TNF-alpha may play a key role in contributing to cardiovascular risk in central obesity subjects.

Authors+Show Affiliations

Department of Endocrinology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

17698217

Citation

Cao, Yan Li, et al. "Correlation Between Omental TNF-alpha Protein and Plasma PAI-1 in Obesity Subjects." International Journal of Cardiology, vol. 128, no. 3, 2008, pp. 399-405.
Cao YL, Wang YX, Wang DF, et al. Correlation between omental TNF-alpha protein and plasma PAI-1 in obesity subjects. Int J Cardiol. 2008;128(3):399-405.
Cao, Y. L., Wang, Y. X., Wang, D. F., Meng, X., & Zhang, J. (2008). Correlation between omental TNF-alpha protein and plasma PAI-1 in obesity subjects. International Journal of Cardiology, 128(3), pp. 399-405.
Cao YL, et al. Correlation Between Omental TNF-alpha Protein and Plasma PAI-1 in Obesity Subjects. Int J Cardiol. 2008 Aug 29;128(3):399-405. PubMed PMID: 17698217.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between omental TNF-alpha protein and plasma PAI-1 in obesity subjects. AU - Cao,Yan Li, AU - Wang,Yu Xia, AU - Wang,Di Fei, AU - Meng,Xin, AU - Zhang,Jin, Y1 - 2007/08/15/ PY - 2007/01/30/received PY - 2007/05/28/revised PY - 2007/05/30/accepted PY - 2007/8/19/pubmed PY - 2009/2/4/medline PY - 2007/8/19/entrez SP - 399 EP - 405 JF - International journal of cardiology JO - Int. J. Cardiol. VL - 128 IS - 3 N2 - BACKGROUND: The role of TNF-alpha in contributing to obesity-associated cardiovascular and metabolic risk has gained much attention. MATERIALS AND METHODS: Paired biopsies of omental and subcutaneous fat were collected from 16 lean subjects and 32 central obesity subjects. The expression of TNF-alpha in omental and subcutaneous fat was quantified by western blotting method, and correlations with plasma PAI-1, homeostasis model assessment insulin resistance (HOMA-IR), and lipid were investigated. RESULTS: In obese female, TNF-alpha expression was higher in the omental than in the subcutaneous fat tissue. There was no significant difference in the levels of TNF-alpha between subcutaneous and visceral fat in obese male. Significant positive correlations were found between omental TNF-alpha protein and plasma PAI-1 levels in obesity. In obese female subjects, omental TNF-alpha protein levels showed a close association with most of the parameters studied: fasting glucose (r=0.541, P<0.05); fasting insulin (r=0.599, P<0.01); HOMA-IR (r=0.546, P<0.05); triglycerides (r=0.469, P<0.05); HDL-cholesterol (r=-0.759, P<0.01). In obese male population, correlations between omental TNF-alpha protein levels and fasting glucose (r=0.762, P<0.01); fasting insulin (r=0.622, P<0.05); triglycerides (r=0.650, P<0.05); HDL-cholesterol (r=-0.880, P<0.01) were found. CONCLUSION: Omental TNF-alpha may play a key role in contributing to cardiovascular risk in central obesity subjects. SN - 1874-1754 UR - https://www.unboundmedicine.com/medline/citation/17698217/Correlation_between_omental_TNF_alpha_protein_and_plasma_PAI_1_in_obesity_subjects_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0167-5273(07)01113-8 DB - PRIME DP - Unbound Medicine ER -