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Independent impact of gout on mortality and risk for coronary heart disease.
Circulation. 2007 Aug 21; 116(8):894-900.Circ

Abstract

BACKGROUND

Although gout and hyperuricemia are related to several conditions that are associated with reduced survival, no prospective data are available on the independent impact of gout on mortality. Furthermore, although many studies have suggested that hyperuricemia is associated with cardiovascular disease (CVD), limited data are available on the impact of gout on CVD.

METHODS AND RESULTS

Over a 12-year period, we prospectively examined the relation between a history of gout and the risk of death and myocardial infarction in 51,297 male participants of the Health Professionals Follow-Up Study. During the 12 years of follow-up, we documented 5825 deaths from all causes, which included 2132 deaths from CVD and 1576 deaths from coronary heart disease (CHD). Compared with men without history of gout and CHD at baseline, the multivariate relative risks among men with history of gout were 1.28 (95% confidence interval [CI], 1.15 to 1.41) for total mortality, 1.38 (95% CI, 1.15 to 1.66) for CVD deaths, and 1.55 (95% CI, 1.24 to 1.93) for fatal CHD. The corresponding relative risks among men with preexisting CHD were 1.25 (95% CI, 1.09 to 1.45), 1.26 (95% CI, 1.07 to 1.50), and 1.24 (95% CI, 1.04 to 1.49), respectively. In addition, men with gout had a higher risk of nonfatal myocardial infarction than men without gout (multivariate relative risk, 1.59; 95% CI, 1.04 to 2.41).

CONCLUSIONS

These prospective data indicate that men with gout have a higher risk of death from all causes. Among men without preexisting CHD, the increased mortality risk is primarily a result of an elevated risk of CVD death, particularly from CHD.

Authors+Show Affiliations

Rheumatology Division, Arthritis Research Centre of Canada, Department of Medicine, Vancouver General Hospital, University of British Columbia, Vancouver, Canada.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17698728

Citation

Choi, Hyon K., and Gary Curhan. "Independent Impact of Gout On Mortality and Risk for Coronary Heart Disease." Circulation, vol. 116, no. 8, 2007, pp. 894-900.
Choi HK, Curhan G. Independent impact of gout on mortality and risk for coronary heart disease. Circulation. 2007;116(8):894-900.
Choi, H. K., & Curhan, G. (2007). Independent impact of gout on mortality and risk for coronary heart disease. Circulation, 116(8), 894-900.
Choi HK, Curhan G. Independent Impact of Gout On Mortality and Risk for Coronary Heart Disease. Circulation. 2007 Aug 21;116(8):894-900. PubMed PMID: 17698728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Independent impact of gout on mortality and risk for coronary heart disease. AU - Choi,Hyon K, AU - Curhan,Gary, Y1 - 2007/08/13/ PY - 2007/8/19/pubmed PY - 2007/9/12/medline PY - 2007/8/19/entrez SP - 894 EP - 900 JF - Circulation JO - Circulation VL - 116 IS - 8 N2 - BACKGROUND: Although gout and hyperuricemia are related to several conditions that are associated with reduced survival, no prospective data are available on the independent impact of gout on mortality. Furthermore, although many studies have suggested that hyperuricemia is associated with cardiovascular disease (CVD), limited data are available on the impact of gout on CVD. METHODS AND RESULTS: Over a 12-year period, we prospectively examined the relation between a history of gout and the risk of death and myocardial infarction in 51,297 male participants of the Health Professionals Follow-Up Study. During the 12 years of follow-up, we documented 5825 deaths from all causes, which included 2132 deaths from CVD and 1576 deaths from coronary heart disease (CHD). Compared with men without history of gout and CHD at baseline, the multivariate relative risks among men with history of gout were 1.28 (95% confidence interval [CI], 1.15 to 1.41) for total mortality, 1.38 (95% CI, 1.15 to 1.66) for CVD deaths, and 1.55 (95% CI, 1.24 to 1.93) for fatal CHD. The corresponding relative risks among men with preexisting CHD were 1.25 (95% CI, 1.09 to 1.45), 1.26 (95% CI, 1.07 to 1.50), and 1.24 (95% CI, 1.04 to 1.49), respectively. In addition, men with gout had a higher risk of nonfatal myocardial infarction than men without gout (multivariate relative risk, 1.59; 95% CI, 1.04 to 2.41). CONCLUSIONS: These prospective data indicate that men with gout have a higher risk of death from all causes. Among men without preexisting CHD, the increased mortality risk is primarily a result of an elevated risk of CVD death, particularly from CHD. SN - 1524-4539 UR - https://www.unboundmedicine.com/medline/citation/17698728/Independent_impact_of_gout_on_mortality_and_risk_for_coronary_heart_disease_ L2 - https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.107.703389?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -