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Nephrotoxicity and its prevention by taurine in tamoxifen induced oxidative stress in mice.
Hum Exp Toxicol. 2007 Jun; 26(6):509-18.HE

Abstract

Tamoxifen (TAM) is an anti-neoplastic drug used for the treatment of breast cancer. It decreases the hexose monophosphate shunt and thereby increasing the incidence of oxidative stress in cells leading to tissue injury. The present study was undertaken to investigate modulatory effects of taurine on the nephrotoxicity of TAM with special reference to protection against disruption of nonenzymatic and enzymatic antioxidants. Oxidative stress was measured by renal lipid peroxidation (LPO) level, protein carbonyl (PC) content, reduced glutathione (GSH), activities of phase I and II drug metabolizing and antioxidant enzymes. TAM treatment resulted in a significant (P < 0.001) increase in LPO in kidney tissues as compared to control, while taurine pretreatment showed a significant decrease (P < 0.01) in the LPO in kidneys when compared with the TAM-treated group. Taurine + TAM group animals showed restoration in the level of cytochrome P450 content, activities of glutathione metabolizing enzymes viz., glutathione-S-transferase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase. Pretreatment of animals with taurine markedly attenuated, PC content, restored the depleted nonenzymatic and enzymatic antioxidants. These results clearly demonstrate the role of oxidative stress, and suggest a protective effect of taurine on TAM-induced nephrotoxicity in mice.

Authors+Show Affiliations

Immunotoxicology Laboratory, Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University), New Delhi, India.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17698946

Citation

Tabassum, Heena, et al. "Nephrotoxicity and Its Prevention By Taurine in Tamoxifen Induced Oxidative Stress in Mice." Human & Experimental Toxicology, vol. 26, no. 6, 2007, pp. 509-18.
Tabassum H, Parvez S, Rehman H, et al. Nephrotoxicity and its prevention by taurine in tamoxifen induced oxidative stress in mice. Hum Exp Toxicol. 2007;26(6):509-18.
Tabassum, H., Parvez, S., Rehman, H., Dev Banerjee, B., Siemen, D., & Raisuddin, S. (2007). Nephrotoxicity and its prevention by taurine in tamoxifen induced oxidative stress in mice. Human & Experimental Toxicology, 26(6), 509-18.
Tabassum H, et al. Nephrotoxicity and Its Prevention By Taurine in Tamoxifen Induced Oxidative Stress in Mice. Hum Exp Toxicol. 2007;26(6):509-18. PubMed PMID: 17698946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nephrotoxicity and its prevention by taurine in tamoxifen induced oxidative stress in mice. AU - Tabassum,Heena, AU - Parvez,Suhel, AU - Rehman,Hasibur, AU - Dev Banerjee,Basu, AU - Siemen,Detlef, AU - Raisuddin,Sheikh, PY - 2007/8/21/pubmed PY - 2007/10/17/medline PY - 2007/8/21/entrez SP - 509 EP - 18 JF - Human & experimental toxicology JO - Hum Exp Toxicol VL - 26 IS - 6 N2 - Tamoxifen (TAM) is an anti-neoplastic drug used for the treatment of breast cancer. It decreases the hexose monophosphate shunt and thereby increasing the incidence of oxidative stress in cells leading to tissue injury. The present study was undertaken to investigate modulatory effects of taurine on the nephrotoxicity of TAM with special reference to protection against disruption of nonenzymatic and enzymatic antioxidants. Oxidative stress was measured by renal lipid peroxidation (LPO) level, protein carbonyl (PC) content, reduced glutathione (GSH), activities of phase I and II drug metabolizing and antioxidant enzymes. TAM treatment resulted in a significant (P < 0.001) increase in LPO in kidney tissues as compared to control, while taurine pretreatment showed a significant decrease (P < 0.01) in the LPO in kidneys when compared with the TAM-treated group. Taurine + TAM group animals showed restoration in the level of cytochrome P450 content, activities of glutathione metabolizing enzymes viz., glutathione-S-transferase, glutathione peroxidase, glutathione reductase, glucose-6-phosphate dehydrogenase. Pretreatment of animals with taurine markedly attenuated, PC content, restored the depleted nonenzymatic and enzymatic antioxidants. These results clearly demonstrate the role of oxidative stress, and suggest a protective effect of taurine on TAM-induced nephrotoxicity in mice. SN - 0960-3271 UR - https://www.unboundmedicine.com/medline/citation/17698946/Nephrotoxicity_and_its_prevention_by_taurine_in_tamoxifen_induced_oxidative_stress_in_mice_ L2 - https://journals.sagepub.com/doi/10.1177/0960327107072392?url_ver=Z39.88-2003&amp;rfr_id=ori:rid:crossref.org&amp;rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -