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Peritoneal dialysis with solutions containing amino acids plus glucose promotes protein synthesis during oral feeding.
Clin J Am Soc Nephrol. 2007 Jan; 2(1):74-80.CJ

Abstract

Inadequate food intake plays an important role in the development of malnutrition. Recently, an increased rate of protein anabolism was shown in fasting state in patients who were on automated peritoneal dialysis with combined amino acids (AA) and glucose (G) dialysate serving as a source of both proteins and calories. This study investigated the effects of such a dialysis procedure in the daytime in the fed state in patients who were on continuous ambulatory peritoneal dialysis (CAPD). A crossover study was performed in 12 CAPD patients to compare, at 7-d intervals, a mixture of AA (Nutrineal 1.1%) plus G (Physioneal l.36 to 3.86%) versus G only as control dialysate. Whole-body protein turnover was studied by primed constant intravenous infusion of (13)C-leucine during the 9-h dialysis. For meeting steady-state conditions during whole-body protein turnover, frequent exchanges with a mixture of AA plus G were done using an automated cycler. Fed-state conditions were created by identical liquid hourly meals. Using AA plus G dialysate, as compared with the control, rates of protein synthesis increased significantly (2.02 +/- 0.08 versus 1.94 +/- 0.07 mumol leucine/kg per min [mean +/- SEM]; P = 0.039). Rates of protein breakdown and net protein balance did not differ significantly between AA plus G and G. In conclusion, dialysate that contains AA plus G also improves protein synthesis in fed CAPD patients. The use of such a mixture may contribute to long-term improvement of the nutritional status in malnourished CAPD patients with deficient food intake.

Authors+Show Affiliations

Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. h.tjiong@erasmusmc.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17699390

Citation

Tjiong, Hoey Lan, et al. "Peritoneal Dialysis With Solutions Containing Amino Acids Plus Glucose Promotes Protein Synthesis During Oral Feeding." Clinical Journal of the American Society of Nephrology : CJASN, vol. 2, no. 1, 2007, pp. 74-80.
Tjiong HL, Rietveld T, Wattimena JL, et al. Peritoneal dialysis with solutions containing amino acids plus glucose promotes protein synthesis during oral feeding. Clin J Am Soc Nephrol. 2007;2(1):74-80.
Tjiong, H. L., Rietveld, T., Wattimena, J. L., van den Berg, J. W., Kahriman, D., van der Steen, J., Hop, W. C., Swart, R., & Fieren, M. W. (2007). Peritoneal dialysis with solutions containing amino acids plus glucose promotes protein synthesis during oral feeding. Clinical Journal of the American Society of Nephrology : CJASN, 2(1), 74-80.
Tjiong HL, et al. Peritoneal Dialysis With Solutions Containing Amino Acids Plus Glucose Promotes Protein Synthesis During Oral Feeding. Clin J Am Soc Nephrol. 2007;2(1):74-80. PubMed PMID: 17699390.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Peritoneal dialysis with solutions containing amino acids plus glucose promotes protein synthesis during oral feeding. AU - Tjiong,Hoey Lan, AU - Rietveld,Trinet, AU - Wattimena,Josias L, AU - van den Berg,Jacobus W, AU - Kahriman,Devada, AU - van der Steen,José, AU - Hop,Wim C, AU - Swart,Roel, AU - Fieren,Marien W, Y1 - 2006/11/08/ PY - 2007/8/21/pubmed PY - 2007/9/12/medline PY - 2007/8/21/entrez SP - 74 EP - 80 JF - Clinical journal of the American Society of Nephrology : CJASN JO - Clin J Am Soc Nephrol VL - 2 IS - 1 N2 - Inadequate food intake plays an important role in the development of malnutrition. Recently, an increased rate of protein anabolism was shown in fasting state in patients who were on automated peritoneal dialysis with combined amino acids (AA) and glucose (G) dialysate serving as a source of both proteins and calories. This study investigated the effects of such a dialysis procedure in the daytime in the fed state in patients who were on continuous ambulatory peritoneal dialysis (CAPD). A crossover study was performed in 12 CAPD patients to compare, at 7-d intervals, a mixture of AA (Nutrineal 1.1%) plus G (Physioneal l.36 to 3.86%) versus G only as control dialysate. Whole-body protein turnover was studied by primed constant intravenous infusion of (13)C-leucine during the 9-h dialysis. For meeting steady-state conditions during whole-body protein turnover, frequent exchanges with a mixture of AA plus G were done using an automated cycler. Fed-state conditions were created by identical liquid hourly meals. Using AA plus G dialysate, as compared with the control, rates of protein synthesis increased significantly (2.02 +/- 0.08 versus 1.94 +/- 0.07 mumol leucine/kg per min [mean +/- SEM]; P = 0.039). Rates of protein breakdown and net protein balance did not differ significantly between AA plus G and G. In conclusion, dialysate that contains AA plus G also improves protein synthesis in fed CAPD patients. The use of such a mixture may contribute to long-term improvement of the nutritional status in malnourished CAPD patients with deficient food intake. SN - 1555-905X UR - https://www.unboundmedicine.com/medline/citation/17699390/Peritoneal_dialysis_with_solutions_containing_amino_acids_plus_glucose_promotes_protein_synthesis_during_oral_feeding_ L2 - http://cjasn.asnjournals.org/cgi/pmidlookup?view=long&pmid=17699390 DB - PRIME DP - Unbound Medicine ER -