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Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's disease.
Dement Geriatr Cogn Disord. 2007; 24(4):253-9.DG

Abstract

BACKGROUND

Neuropsychiatric disturbances are common in mild cognitive impairment (MCI). Depression and apathy may identify a subset of MCI subjects at higher risk of progression to Alzheimer's disease (AD). However, it remains uncertain whether a broader spectrum of psychopathology is associated with progression to AD.

METHODS

Fifty-one MCI subjects were assessed for neuropsychiatric symptoms using the Neuropsychiatric Inventory. Subjects were followed for an average of 2 years. Twelve subjects (23.5%) progressed from MCI to possible/probable AD and 39 subjects (76.5%) remained stable or improved. Baseline Neuropsychiatric Inventory indices were compared between groups.

RESULTS

Subjects progressing to AD had a significantly higher prevalence of psychopathology than subjects who remained stable or improved (100 vs. 59%). Depression (67 vs. 31%) and apathy (50 vs. 18%) were more common in subjects who were later diagnosed with AD. After statistical adjustments for other baseline demographic variables, these specific symptoms were less robust predictors of progression to AD than the presence of any psychopathology.

CONCLUSIONS

These findings suggest that neuropsychiatric symptoms in MCI are a predictor of progression to AD. Depression and apathy appear to be most useful for identifying MCI subjects at highest risk of developing dementia.

Authors+Show Affiliations

Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-7226, USA. eteng@ucla.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17700021

Citation

Teng, Edmond, et al. "Neuropsychiatric Symptoms Are Associated With Progression From Mild Cognitive Impairment to Alzheimer's Disease." Dementia and Geriatric Cognitive Disorders, vol. 24, no. 4, 2007, pp. 253-9.
Teng E, Lu PH, Cummings JL. Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's disease. Dement Geriatr Cogn Disord. 2007;24(4):253-9.
Teng, E., Lu, P. H., & Cummings, J. L. (2007). Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's disease. Dementia and Geriatric Cognitive Disorders, 24(4), 253-9.
Teng E, Lu PH, Cummings JL. Neuropsychiatric Symptoms Are Associated With Progression From Mild Cognitive Impairment to Alzheimer's Disease. Dement Geriatr Cogn Disord. 2007;24(4):253-9. PubMed PMID: 17700021.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuropsychiatric symptoms are associated with progression from mild cognitive impairment to Alzheimer's disease. AU - Teng,Edmond, AU - Lu,Po H, AU - Cummings,Jeffrey L, Y1 - 2007/08/14/ PY - 2007/06/06/accepted PY - 2007/8/19/pubmed PY - 2007/12/6/medline PY - 2007/8/19/entrez SP - 253 EP - 9 JF - Dementia and geriatric cognitive disorders JO - Dement Geriatr Cogn Disord VL - 24 IS - 4 N2 - BACKGROUND: Neuropsychiatric disturbances are common in mild cognitive impairment (MCI). Depression and apathy may identify a subset of MCI subjects at higher risk of progression to Alzheimer's disease (AD). However, it remains uncertain whether a broader spectrum of psychopathology is associated with progression to AD. METHODS: Fifty-one MCI subjects were assessed for neuropsychiatric symptoms using the Neuropsychiatric Inventory. Subjects were followed for an average of 2 years. Twelve subjects (23.5%) progressed from MCI to possible/probable AD and 39 subjects (76.5%) remained stable or improved. Baseline Neuropsychiatric Inventory indices were compared between groups. RESULTS: Subjects progressing to AD had a significantly higher prevalence of psychopathology than subjects who remained stable or improved (100 vs. 59%). Depression (67 vs. 31%) and apathy (50 vs. 18%) were more common in subjects who were later diagnosed with AD. After statistical adjustments for other baseline demographic variables, these specific symptoms were less robust predictors of progression to AD than the presence of any psychopathology. CONCLUSIONS: These findings suggest that neuropsychiatric symptoms in MCI are a predictor of progression to AD. Depression and apathy appear to be most useful for identifying MCI subjects at highest risk of developing dementia. SN - 1420-8008 UR - https://www.unboundmedicine.com/medline/citation/17700021/Neuropsychiatric_symptoms_are_associated_with_progression_from_mild_cognitive_impairment_to_Alzheimer's_disease_ L2 - https://www.karger.com?DOI=10.1159/000107100 DB - PRIME DP - Unbound Medicine ER -