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Glomerular charge selectivity in non-insulin-dependent diabetes mellitus.
J Diabet Complications. 1991 Apr-Sep; 5(2-3):135-7.JD

Abstract

To elucidate the stage of the charge selectivity defect in diabetic nephropathy, urinary excretions of IgG1 and IgG4 were measured in patients with non-insulin-dependent diabetes mellitus (NIDDM) and healthy controls. The molecular weights of IgG1 and IgG4 were the same but their isoelectric points were different. Therefore, by measuring both urinary IgG1 and IgG4 excretions, the stage of charge selectivity impairment in the nephropathy of NIDDM may be elucidated. Results were expressed as urinary excretion rate (IgG1 ER, IgG4 ER) and compared between diabetic patients with different urinary excretion rates of albumin (AER). IgG4 ER increased to the stage in which AER was more than 10 micrograms/min, whereas IgG1 ER did not increase to the stage of AER between 10 and 100 micrograms/min. This finding suggests that the charge selectivity defect in the kidney of the NIDDM patient is present at the stage when AER is more than 10 micrograms/min.

Authors+Show Affiliations

Chiba Y
First Department of Internal Medicine, Niigata University, School of Medicine, Japan.
Tani N
No affiliation info available
Yamazaki M
No affiliation info available
Nakamura H
No affiliation info available
Ito S
No affiliation info available
Shibata A
No affiliation info available

MeSH

AlbuminuriaDiabetes Mellitus, Type 2Diabetic NephropathiesHumansImmunoglobulin GKidney GlomerulusReference Values

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1770022

Citation

Chiba, Y, et al. "Glomerular Charge Selectivity in Non-insulin-dependent Diabetes Mellitus." The Journal of Diabetic Complications, vol. 5, no. 2-3, 1991, pp. 135-7.
Chiba Y, Tani N, Yamazaki M, et al. Glomerular charge selectivity in non-insulin-dependent diabetes mellitus. J Diabet Complications. 1991;5(2-3):135-7.
Chiba, Y., Tani, N., Yamazaki, M., Nakamura, H., Ito, S., & Shibata, A. (1991). Glomerular charge selectivity in non-insulin-dependent diabetes mellitus. The Journal of Diabetic Complications, 5(2-3), 135-7.
Chiba Y, et al. Glomerular Charge Selectivity in Non-insulin-dependent Diabetes Mellitus. J Diabet Complications. 1991 Apr-Sep;5(2-3):135-7. PubMed PMID: 1770022.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Glomerular charge selectivity in non-insulin-dependent diabetes mellitus. AU - Chiba,Y, AU - Tani,N, AU - Yamazaki,M, AU - Nakamura,H, AU - Ito,S, AU - Shibata,A, PY - 1991/4/1/pubmed PY - 1991/4/1/medline PY - 1991/4/1/entrez SP - 135 EP - 7 JF - The Journal of diabetic complications JO - J Diabet Complications VL - 5 IS - 2-3 N2 - To elucidate the stage of the charge selectivity defect in diabetic nephropathy, urinary excretions of IgG1 and IgG4 were measured in patients with non-insulin-dependent diabetes mellitus (NIDDM) and healthy controls. The molecular weights of IgG1 and IgG4 were the same but their isoelectric points were different. Therefore, by measuring both urinary IgG1 and IgG4 excretions, the stage of charge selectivity impairment in the nephropathy of NIDDM may be elucidated. Results were expressed as urinary excretion rate (IgG1 ER, IgG4 ER) and compared between diabetic patients with different urinary excretion rates of albumin (AER). IgG4 ER increased to the stage in which AER was more than 10 micrograms/min, whereas IgG1 ER did not increase to the stage of AER between 10 and 100 micrograms/min. This finding suggests that the charge selectivity defect in the kidney of the NIDDM patient is present at the stage when AER is more than 10 micrograms/min. SN - 0891-6632 UR - https://www.unboundmedicine.com/medline/citation/1770022/Glomerular_charge_selectivity_in_non_insulin_dependent_diabetes_mellitus_ DB - PRIME DP - Unbound Medicine ER -