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Is ineffective oesophageal motility associated with reflux oesophagitis?
Eur J Gastroenterol Hepatol 2007; 19(9):783-7EJ

Abstract

OBJECTIVE

To evaluate the association between ineffective oesophageal motility and reflux oesophagitis controlling for hiatal hernia, hypotensive lower oesophageal sphincter and male sex in patients with gastro-oesophageal reflux disease.

METHODS

A total of 387 patients with reflux disease (mean age, 46 years, 42% men) were consecutively selected from a database. All patients underwent upper endoscopy, oesophageal manometry and 24 h oesophageal pH-metry in accordance with a standardized protocol. Reflux disease was confirmed either by endoscopy (oesophagitis grade I-IV according to Savary-Miller) or by pH-metry (increased acid exposure). Hiatal hernia was diagnosed endoscopically, whereas ineffective oesophageal motility and hypotensive lower oesophageal sphincter were characterized during manometry testing. The association between ineffective oesophageal motility and reflux oesophagitis was assessed by logistic regression analysis.

RESULTS

A total of 166 patients with oesophagitis (mean age 45 years, 49% men) and 221 without oesophagitis (mean age 46 years, 37% men) were present. Prevalences of ineffective oesophageal motility, hiatal hernia, hypotensive lower oesophageal sphincter and male sex were significantly higher in patients with oesophagitis compared with those without oesophagitis (P<0.05). Ineffective oesophageal motility was independently associated with oesophagitis after multivariate logistic regression analysis (odds ratio=1.68; 95% confidence interval=1.04-2.70).

CONCLUSION

Ineffective oesophageal motility is associated with reflux oesophagitis, independently of hiatal hernia, hypotensive lower oesophageal sphincter and male sex.

Authors+Show Affiliations

Sciences in Gastroenterology, School of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil. Fernando.Fornari@med.kuleuven.beNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17700264

Citation

Fornari, Fernando, et al. "Is Ineffective Oesophageal Motility Associated With Reflux Oesophagitis?" European Journal of Gastroenterology & Hepatology, vol. 19, no. 9, 2007, pp. 783-7.
Fornari F, Callegari-Jacques SM, Scussel PJ, et al. Is ineffective oesophageal motility associated with reflux oesophagitis? Eur J Gastroenterol Hepatol. 2007;19(9):783-7.
Fornari, F., Callegari-Jacques, S. M., Scussel, P. J., Madalosso, L. F., Barros, E. F., & Barros, S. G. (2007). Is ineffective oesophageal motility associated with reflux oesophagitis? European Journal of Gastroenterology & Hepatology, 19(9), pp. 783-7.
Fornari F, et al. Is Ineffective Oesophageal Motility Associated With Reflux Oesophagitis. Eur J Gastroenterol Hepatol. 2007;19(9):783-7. PubMed PMID: 17700264.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Is ineffective oesophageal motility associated with reflux oesophagitis? AU - Fornari,Fernando, AU - Callegari-Jacques,Sidia M, AU - Scussel,Plácido J, AU - Madalosso,Luiz F, AU - Barros,Enrique F, AU - Barros,Sérgio G S, PY - 2007/8/19/pubmed PY - 2007/10/3/medline PY - 2007/8/19/entrez SP - 783 EP - 7 JF - European journal of gastroenterology & hepatology JO - Eur J Gastroenterol Hepatol VL - 19 IS - 9 N2 - OBJECTIVE: To evaluate the association between ineffective oesophageal motility and reflux oesophagitis controlling for hiatal hernia, hypotensive lower oesophageal sphincter and male sex in patients with gastro-oesophageal reflux disease. METHODS: A total of 387 patients with reflux disease (mean age, 46 years, 42% men) were consecutively selected from a database. All patients underwent upper endoscopy, oesophageal manometry and 24 h oesophageal pH-metry in accordance with a standardized protocol. Reflux disease was confirmed either by endoscopy (oesophagitis grade I-IV according to Savary-Miller) or by pH-metry (increased acid exposure). Hiatal hernia was diagnosed endoscopically, whereas ineffective oesophageal motility and hypotensive lower oesophageal sphincter were characterized during manometry testing. The association between ineffective oesophageal motility and reflux oesophagitis was assessed by logistic regression analysis. RESULTS: A total of 166 patients with oesophagitis (mean age 45 years, 49% men) and 221 without oesophagitis (mean age 46 years, 37% men) were present. Prevalences of ineffective oesophageal motility, hiatal hernia, hypotensive lower oesophageal sphincter and male sex were significantly higher in patients with oesophagitis compared with those without oesophagitis (P<0.05). Ineffective oesophageal motility was independently associated with oesophagitis after multivariate logistic regression analysis (odds ratio=1.68; 95% confidence interval=1.04-2.70). CONCLUSION: Ineffective oesophageal motility is associated with reflux oesophagitis, independently of hiatal hernia, hypotensive lower oesophageal sphincter and male sex. SN - 0954-691X UR - https://www.unboundmedicine.com/medline/citation/17700264/Is_ineffective_oesophageal_motility_associated_with_reflux_oesophagitis L2 - http://Insights.ovid.com/pubmed?pmid=17700264 DB - PRIME DP - Unbound Medicine ER -