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Taurine fails to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion in mice.
Amino Acids. 2008 Aug; 35(2):457-61.AA

Abstract

Taurine, a known antioxidant and neuroprotector has been investigated for its free radical scavenging action in vitro in isolated mitochondria, and tested whether it protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in mice. Taurine (0.1-10 mM) did not affect 1-methyl-4-phenyl pyridinium-induced hydroxyl radical production in isolated mitochondria. Systemic administration of taurine (250 mg/kg, i.p.) caused a small, but significant loss of dopamine levels in the striatum of mice. Taurine failed to reverse MPTP-induced striatal dopamine depletion, but caused significant increase in dopamine turnover in these animals. In the light of the present study it may be suggested that consumption of taurine may neither help in scavenging of neurotoxic hydroxyl radicals in the brain mitochondria, nor would it help in blocking the process of neurodegeneration.

Authors+Show Affiliations

Laboratory of Clinical and Experimental Neuroscience, Division of Cell Biology and Physiology, Indian Institute of Chemical Biology, Jadavpur, Kolkata, India.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17701098

Citation

Navneet, A K., et al. "Taurine Fails to Protect Against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Striatal Dopamine Depletion in Mice." Amino Acids, vol. 35, no. 2, 2008, pp. 457-61.
Navneet AK, Appukuttan TA, Pandey M, et al. Taurine fails to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion in mice. Amino Acids. 2008;35(2):457-61.
Navneet, A. K., Appukuttan, T. A., Pandey, M., & Mohanakumar, K. P. (2008). Taurine fails to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion in mice. Amino Acids, 35(2), 457-61.
Navneet AK, et al. Taurine Fails to Protect Against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Striatal Dopamine Depletion in Mice. Amino Acids. 2008;35(2):457-61. PubMed PMID: 17701098.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Taurine fails to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced striatal dopamine depletion in mice. AU - Navneet,A K, AU - Appukuttan,T A, AU - Pandey,M, AU - Mohanakumar,K P, Y1 - 2007/08/15/ PY - 2007/05/14/received PY - 2007/06/12/accepted PY - 2007/8/19/pubmed PY - 2008/10/10/medline PY - 2007/8/19/entrez SP - 457 EP - 61 JF - Amino acids JO - Amino Acids VL - 35 IS - 2 N2 - Taurine, a known antioxidant and neuroprotector has been investigated for its free radical scavenging action in vitro in isolated mitochondria, and tested whether it protects against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced dopaminergic neurodegeneration in mice. Taurine (0.1-10 mM) did not affect 1-methyl-4-phenyl pyridinium-induced hydroxyl radical production in isolated mitochondria. Systemic administration of taurine (250 mg/kg, i.p.) caused a small, but significant loss of dopamine levels in the striatum of mice. Taurine failed to reverse MPTP-induced striatal dopamine depletion, but caused significant increase in dopamine turnover in these animals. In the light of the present study it may be suggested that consumption of taurine may neither help in scavenging of neurotoxic hydroxyl radicals in the brain mitochondria, nor would it help in blocking the process of neurodegeneration. SN - 1438-2199 UR - https://www.unboundmedicine.com/medline/citation/17701098/Taurine_fails_to_protect_against_1_methyl_4_phenyl_1236_tetrahydropyridine_induced_striatal_dopamine_depletion_in_mice_ L2 - https://dx.doi.org/10.1007/s00726-007-0571-7 DB - PRIME DP - Unbound Medicine ER -