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Preparation and characterization of magnetic poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) microspheres.
J Mater Sci Mater Med 2008; 19(3):1033-41JM

Abstract

In this article, nano-magnetite particles (ferrofluid, Fe3O4) were prepared by chemical co-deposition method. A series of biodegradable triblock poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL, PCEC) copolymers were synthesized by ring-opening polymerization method from epsilon-caprolactone (epsilon-CL) initiated by poly(ethylene glycol) diol (PEG) using stannous octoate as catalyst. And the magnetic PCEC composite microspheres were prepared by solvent diffusion method. The properties of the ferrofluid, PCEC copolymer, and magnetic PCEC microspheres were studied in detail by SEM, VSM, XRD, Malvern Laser Particle Sizer, 1H-NMR, GPC, and TG/DTG. Effects of macromolecular weight and concentration of polymer, and the time for ultrasound dispersion on properties of magnetic microspheres were also investigated. The obtained magnetic PCEC microspheres might have great potential application in targeted drug delivery system or cell separation.

Authors+Show Affiliations

State Key Laboratory of Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, 610041, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17701292

Citation

Gou, Ma Ling, et al. "Preparation and Characterization of Magnetic Poly(epsilon-caprolactone)-poly(ethylene Glycol)-poly(epsilon-caprolactone) Microspheres." Journal of Materials Science. Materials in Medicine, vol. 19, no. 3, 2008, pp. 1033-41.
Gou ML, Qian ZY, Wang H, et al. Preparation and characterization of magnetic poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) microspheres. J Mater Sci Mater Med. 2008;19(3):1033-41.
Gou, M. L., Qian, Z. Y., Wang, H., Tang, Y. B., Huang, M. J., Kan, B., ... Tu, M. J. (2008). Preparation and characterization of magnetic poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) microspheres. Journal of Materials Science. Materials in Medicine, 19(3), pp. 1033-41.
Gou ML, et al. Preparation and Characterization of Magnetic Poly(epsilon-caprolactone)-poly(ethylene Glycol)-poly(epsilon-caprolactone) Microspheres. J Mater Sci Mater Med. 2008;19(3):1033-41. PubMed PMID: 17701292.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Preparation and characterization of magnetic poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) microspheres. AU - Gou,Ma Ling, AU - Qian,Zhi Yong, AU - Wang,Hui, AU - Tang,Yong Bo, AU - Huang,Mei Juan, AU - Kan,Bing, AU - Wen,Yan Juan, AU - Dai,Mei, AU - Li,Xing Yi, AU - Gong,Chang Yang, AU - Tu,Ming Jing, Y1 - 2007/08/15/ PY - 2006/07/26/received PY - 2007/06/18/accepted PY - 2007/8/19/pubmed PY - 2008/7/4/medline PY - 2007/8/19/entrez SP - 1033 EP - 41 JF - Journal of materials science. Materials in medicine JO - J Mater Sci Mater Med VL - 19 IS - 3 N2 - In this article, nano-magnetite particles (ferrofluid, Fe3O4) were prepared by chemical co-deposition method. A series of biodegradable triblock poly(epsilon-caprolactone)-poly(ethylene glycol)-poly(epsilon-caprolactone) (PCL-PEG-PCL, PCEC) copolymers were synthesized by ring-opening polymerization method from epsilon-caprolactone (epsilon-CL) initiated by poly(ethylene glycol) diol (PEG) using stannous octoate as catalyst. And the magnetic PCEC composite microspheres were prepared by solvent diffusion method. The properties of the ferrofluid, PCEC copolymer, and magnetic PCEC microspheres were studied in detail by SEM, VSM, XRD, Malvern Laser Particle Sizer, 1H-NMR, GPC, and TG/DTG. Effects of macromolecular weight and concentration of polymer, and the time for ultrasound dispersion on properties of magnetic microspheres were also investigated. The obtained magnetic PCEC microspheres might have great potential application in targeted drug delivery system or cell separation. SN - 0957-4530 UR - https://www.unboundmedicine.com/medline/citation/17701292/Preparation_and_characterization_of_magnetic_poly_epsilon_caprolactone__poly_ethylene_glycol__poly_epsilon_caprolactone__microspheres_ L2 - https://doi.org/10.1007/s10856-007-3230-3 DB - PRIME DP - Unbound Medicine ER -