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Diabetic and non-diabetic subjects with ischemic stroke: differences, subtype distribution and outcome.
Nutr Metab Cardiovasc Dis. 2008 Feb; 18(2):152-7.NM

Abstract

BACKGROUND AND AIM

Diabetes mellitus increases the risk of stroke, and pathophysiological changes of diabetic cerebral vessels may differ in comparison with non-diabetic ones; nonetheless, the clinical and prognostic profile of stroke in diabetic patients is not yet fully understood. On this basis, the aim of our study was to evaluate cerebrovascular risk factor prevalence in diabetic stroke patients in comparison with non-diabetics, to analyze whether diabetics have a different prevalence of stroke subtypes as classified by the TOAST classification, and determine whether diabetics and non-diabetics have a different prognosis.

METHODS AND RESULTS

We enrolled 102 diabetics and 204 non-diabetic subjects with acute ischemic stroke, matched by sex and age (+/-3 years). We used as outcome indicators the Scandinavian Stroke Scale (SSS) score at admission and the modified Rankin disability scale at discharge and at a 6-month follow-up. We classified ischemic stroke according to the TOAST classification. Diabetes was associated with lacunar ischemic stroke subtype, with a record of hypertension, and with a better SSS score at admission. The association of diabetes with lacunar stroke remained significant even after adjustment for hypertension or for large artery atherosclerotic and cardioembolic stroke subtypes.

CONCLUSION

Our study shows some significant differences in acute ischemic stroke among diabetics in comparison with non-diabetics (higher frequency of hypertension, higher prevalence of lacunar stroke subtype, lower neurological deficit at admission in diabetics).

Authors+Show Affiliations

Biomedical Department of Internal and Specialistic Medicine, University of Palermo, P.zza delle Cliniche n.2, 90127 Palermo, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17702553

Citation

Tuttolomondo, Antonino, et al. "Diabetic and Non-diabetic Subjects With Ischemic Stroke: Differences, Subtype Distribution and Outcome." Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, vol. 18, no. 2, 2008, pp. 152-7.
Tuttolomondo A, Pinto A, Salemi G, et al. Diabetic and non-diabetic subjects with ischemic stroke: differences, subtype distribution and outcome. Nutr Metab Cardiovasc Dis. 2008;18(2):152-7.
Tuttolomondo, A., Pinto, A., Salemi, G., Di Raimondo, D., Di Sciacca, R., Fernandez, P., Ragonese, P., Savettieri, G., & Licata, G. (2008). Diabetic and non-diabetic subjects with ischemic stroke: differences, subtype distribution and outcome. Nutrition, Metabolism, and Cardiovascular Diseases : NMCD, 18(2), 152-7.
Tuttolomondo A, et al. Diabetic and Non-diabetic Subjects With Ischemic Stroke: Differences, Subtype Distribution and Outcome. Nutr Metab Cardiovasc Dis. 2008;18(2):152-7. PubMed PMID: 17702553.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Diabetic and non-diabetic subjects with ischemic stroke: differences, subtype distribution and outcome. AU - Tuttolomondo,Antonino, AU - Pinto,Antonio, AU - Salemi,Giuseppe, AU - Di Raimondo,Domenico, AU - Di Sciacca,Riccardo, AU - Fernandez,Paola, AU - Ragonese,Paolo, AU - Savettieri,Giovanni, AU - Licata,Giuseppe, Y1 - 2007/08/16/ PY - 2006/07/28/received PY - 2007/01/17/revised PY - 2007/8/19/pubmed PY - 2008/3/21/medline PY - 2007/8/19/entrez SP - 152 EP - 7 JF - Nutrition, metabolism, and cardiovascular diseases : NMCD JO - Nutr Metab Cardiovasc Dis VL - 18 IS - 2 N2 - BACKGROUND AND AIM: Diabetes mellitus increases the risk of stroke, and pathophysiological changes of diabetic cerebral vessels may differ in comparison with non-diabetic ones; nonetheless, the clinical and prognostic profile of stroke in diabetic patients is not yet fully understood. On this basis, the aim of our study was to evaluate cerebrovascular risk factor prevalence in diabetic stroke patients in comparison with non-diabetics, to analyze whether diabetics have a different prevalence of stroke subtypes as classified by the TOAST classification, and determine whether diabetics and non-diabetics have a different prognosis. METHODS AND RESULTS: We enrolled 102 diabetics and 204 non-diabetic subjects with acute ischemic stroke, matched by sex and age (+/-3 years). We used as outcome indicators the Scandinavian Stroke Scale (SSS) score at admission and the modified Rankin disability scale at discharge and at a 6-month follow-up. We classified ischemic stroke according to the TOAST classification. Diabetes was associated with lacunar ischemic stroke subtype, with a record of hypertension, and with a better SSS score at admission. The association of diabetes with lacunar stroke remained significant even after adjustment for hypertension or for large artery atherosclerotic and cardioembolic stroke subtypes. CONCLUSION: Our study shows some significant differences in acute ischemic stroke among diabetics in comparison with non-diabetics (higher frequency of hypertension, higher prevalence of lacunar stroke subtype, lower neurological deficit at admission in diabetics). SN - 1590-3729 UR - https://www.unboundmedicine.com/medline/citation/17702553/Diabetic_and_non_diabetic_subjects_with_ischemic_stroke:_differences_subtype_distribution_and_outcome_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0939-4753(07)00031-2 DB - PRIME DP - Unbound Medicine ER -