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Risk of pancreatitis in 14,000 individuals with celiac disease.

Abstract

BACKGROUND & AIMS

The aim of this study was to examine the risk of pancreatitis in patients with celiac disease (CD) from a general population cohort.

METHODS

By using Swedish national registers, we identified 14,239 individuals with a diagnosis of CD (1964-2003) and 69,381 reference individuals matched for age, sex, calendar year, and county of residence at the time of diagnosis. Cox regression estimated the hazard ratios (HRs) for a subsequent diagnosis of pancreatitis. We restricted analyses to individuals with more than 1 year of follow-up and no diagnosis of pancreatitis before or within 1 year after study entry. Conditional logistic regression estimated the association of pancreatitis with subsequent CD.

RESULTS

CD was associated with an increased risk of subsequent pancreatitis of any type (HR, 3.3; 95% confidence interval [CI], 2.6-4.4; P < .001; on the basis of 95 positive events in individuals with CD vs 163 positive events in reference individuals) and chronic pancreatitis (HR, 19.8; 95% CI, 9.2-42.8; P < .001; on the basis of 37 and 13 positive events, respectively). Adjustment for socioeconomic index, diabetes mellitus, alcohol-related disorders, or gallstone disease had no notable effect on the risk estimates. The risk increase for pancreatitis was only found among individuals with CD diagnosed in adulthood. Pancreatitis of any type (odds ratio, 3.2; 95% CI, 2.5-4.3; P < .001) and chronic pancreatitis (odds ratio, 7.3; 95% CI, 4.0-13.5; P < .001) were associated with subsequent CD.

CONCLUSIONS

This study suggests that individuals with CD are at increased risk of pancreatitis.

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  • Authors+Show Affiliations

    ,

    Department of Pediatrics, Orebro University Hospital, Linkoping, Sweden. jonasludvigsson@yahoo.com

    ,

    Source

    MeSH

    Adolescent
    Adult
    Aged
    Aged, 80 and over
    Celiac Disease
    Child
    Child, Preschool
    Female
    Humans
    Infant
    Infant, Newborn
    Male
    Middle Aged
    Pancreatitis
    Registries
    Risk Assessment
    Sweden

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    17702659

    Citation

    Ludvigsson, Jonas F., et al. "Risk of Pancreatitis in 14,000 Individuals With Celiac Disease." Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, vol. 5, no. 11, 2007, pp. 1347-53.
    Ludvigsson JF, Montgomery SM, Ekbom A. Risk of pancreatitis in 14,000 individuals with celiac disease. Clin Gastroenterol Hepatol. 2007;5(11):1347-53.
    Ludvigsson, J. F., Montgomery, S. M., & Ekbom, A. (2007). Risk of pancreatitis in 14,000 individuals with celiac disease. Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association, 5(11), pp. 1347-53.
    Ludvigsson JF, Montgomery SM, Ekbom A. Risk of Pancreatitis in 14,000 Individuals With Celiac Disease. Clin Gastroenterol Hepatol. 2007;5(11):1347-53. PubMed PMID: 17702659.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Risk of pancreatitis in 14,000 individuals with celiac disease. AU - Ludvigsson,Jonas F, AU - Montgomery,Scott M, AU - Ekbom,Anders, Y1 - 2007/08/16/ PY - 2007/8/19/pubmed PY - 2007/12/14/medline PY - 2007/8/19/entrez SP - 1347 EP - 53 JF - Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association JO - Clin. Gastroenterol. Hepatol. VL - 5 IS - 11 N2 - BACKGROUND & AIMS: The aim of this study was to examine the risk of pancreatitis in patients with celiac disease (CD) from a general population cohort. METHODS: By using Swedish national registers, we identified 14,239 individuals with a diagnosis of CD (1964-2003) and 69,381 reference individuals matched for age, sex, calendar year, and county of residence at the time of diagnosis. Cox regression estimated the hazard ratios (HRs) for a subsequent diagnosis of pancreatitis. We restricted analyses to individuals with more than 1 year of follow-up and no diagnosis of pancreatitis before or within 1 year after study entry. Conditional logistic regression estimated the association of pancreatitis with subsequent CD. RESULTS: CD was associated with an increased risk of subsequent pancreatitis of any type (HR, 3.3; 95% confidence interval [CI], 2.6-4.4; P < .001; on the basis of 95 positive events in individuals with CD vs 163 positive events in reference individuals) and chronic pancreatitis (HR, 19.8; 95% CI, 9.2-42.8; P < .001; on the basis of 37 and 13 positive events, respectively). Adjustment for socioeconomic index, diabetes mellitus, alcohol-related disorders, or gallstone disease had no notable effect on the risk estimates. The risk increase for pancreatitis was only found among individuals with CD diagnosed in adulthood. Pancreatitis of any type (odds ratio, 3.2; 95% CI, 2.5-4.3; P < .001) and chronic pancreatitis (odds ratio, 7.3; 95% CI, 4.0-13.5; P < .001) were associated with subsequent CD. CONCLUSIONS: This study suggests that individuals with CD are at increased risk of pancreatitis. SN - 1542-7714 UR - https://www.unboundmedicine.com/medline/citation/17702659/Risk_of_pancreatitis_in_14000_individuals_with_celiac_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1542-3565(07)00592-7 DB - PRIME DP - Unbound Medicine ER -