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In-line liquid-phase microextraction for selective enrichment and direct electrophoretic analysis of acidic drugs.
Electrophoresis. 2007 Sep; 28(18):3284-9.E

Abstract

This work describes an efficient in-line extraction-preconcentration unit coupled to the electrophoretic capillary based on a liquid-phase microextraction (LPME) process, which can be directly assembled to the cartridge of the commercial CE equipment. The unit permits analyte extraction, preconcentration and electrophoretic separation to be automatically performed in the commercial CE equipment without the need for additional hardware or software. This new approach was usefully used for the separation and determination of nonsteroidal anti-inflammatory drugs in human urine permitting at least to analyze 30 consecutive real samples. The LODs were lower than 2 microg/L and the reproducibility, expressed as RSD, was 3.1% for the same unit and only 4.8% between different units.

Authors+Show Affiliations

Nozal L
Department of Analytical Chemistry, University of Córdoba, Campus de Rabanales, Córdoba, Spain.
Arce L
No affiliation info available
Simonet BM
No affiliation info available
Ríos A
No affiliation info available
Valcárcel M
No affiliation info available

MeSH

AcidsElectrophoresis, CapillaryPharmaceutical Preparations

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17703465

Citation

Nozal, Leonor, et al. "In-line Liquid-phase Microextraction for Selective Enrichment and Direct Electrophoretic Analysis of Acidic Drugs." Electrophoresis, vol. 28, no. 18, 2007, pp. 3284-9.
Nozal L, Arce L, Simonet BM, et al. In-line liquid-phase microextraction for selective enrichment and direct electrophoretic analysis of acidic drugs. Electrophoresis. 2007;28(18):3284-9.
Nozal, L., Arce, L., Simonet, B. M., Ríos, A., & Valcárcel, M. (2007). In-line liquid-phase microextraction for selective enrichment and direct electrophoretic analysis of acidic drugs. Electrophoresis, 28(18), 3284-9.
Nozal L, et al. In-line Liquid-phase Microextraction for Selective Enrichment and Direct Electrophoretic Analysis of Acidic Drugs. Electrophoresis. 2007;28(18):3284-9. PubMed PMID: 17703465.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In-line liquid-phase microextraction for selective enrichment and direct electrophoretic analysis of acidic drugs. AU - Nozal,Leonor, AU - Arce,Lourdes, AU - Simonet,Bartolomé M, AU - Ríos,Angel, AU - Valcárcel,Miguel, PY - 2007/8/19/pubmed PY - 2007/11/14/medline PY - 2007/8/19/entrez SP - 3284 EP - 9 JF - Electrophoresis JO - Electrophoresis VL - 28 IS - 18 N2 - This work describes an efficient in-line extraction-preconcentration unit coupled to the electrophoretic capillary based on a liquid-phase microextraction (LPME) process, which can be directly assembled to the cartridge of the commercial CE equipment. The unit permits analyte extraction, preconcentration and electrophoretic separation to be automatically performed in the commercial CE equipment without the need for additional hardware or software. This new approach was usefully used for the separation and determination of nonsteroidal anti-inflammatory drugs in human urine permitting at least to analyze 30 consecutive real samples. The LODs were lower than 2 microg/L and the reproducibility, expressed as RSD, was 3.1% for the same unit and only 4.8% between different units. SN - 0173-0835 UR - https://www.unboundmedicine.com/medline/citation/17703465/In_line_liquid_phase_microextraction_for_selective_enrichment_and_direct_electrophoretic_analysis_of_acidic_drugs_ L2 - https://doi.org/10.1002/elps.200600468 DB - PRIME DP - Unbound Medicine ER -