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Matrix properties of a new plant gum in controlled drug delivery.
Arch Pharm Res. 2007 Jul; 30(7):884-9.AP

Abstract

A new plant gum, Okra (extracted from the pods of Hibiscus esculentus), has been evaluated as a controlled-release agent in modified release matrices, in comparison with sodium carboxymethyl cellulose (NaCMC) and hydroxypropylmethyl cellulose (HPMC), using Paracetamol as a model drug. Tablets were produced by direct compression and the in-vitro drug release was assessed in conditions mimicking the gastro intestinal system, for 6 h. Okra gum matrices provided a controlled-release of Paracetamol for more than 6 h and the release rates followed time-independent kinetics. The release rates were dependent on the concentration of the drug present in the matrix. The addition of tablet excipients, lactose and Avicel, altered the dissolution profile and the release kinetics. Okra gum compared favourably with NaCMC, and a combination of Okra gum and NaCMC, or on further addition of HPMC resulted in near zeroorder release of paracetamol from the matrix tablet. The results indicate that Okra gum matrices could be useful in the formulation of sustained-release tablets for up to 6 h.

Authors+Show Affiliations

Department of Pharmaceutics & Industrial Pharmacy, University of Ibadan, Ibadan, Nigeria.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17703742

Citation

Kalu, V D., et al. "Matrix Properties of a New Plant Gum in Controlled Drug Delivery." Archives of Pharmacal Research, vol. 30, no. 7, 2007, pp. 884-9.
Kalu VD, Odeniyi MA, Jaiyeoba KT. Matrix properties of a new plant gum in controlled drug delivery. Arch Pharm Res. 2007;30(7):884-9.
Kalu, V. D., Odeniyi, M. A., & Jaiyeoba, K. T. (2007). Matrix properties of a new plant gum in controlled drug delivery. Archives of Pharmacal Research, 30(7), 884-9.
Kalu VD, Odeniyi MA, Jaiyeoba KT. Matrix Properties of a New Plant Gum in Controlled Drug Delivery. Arch Pharm Res. 2007;30(7):884-9. PubMed PMID: 17703742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Matrix properties of a new plant gum in controlled drug delivery. AU - Kalu,V D, AU - Odeniyi,M A, AU - Jaiyeoba,K T, PY - 2007/8/21/pubmed PY - 2007/10/10/medline PY - 2007/8/21/entrez SP - 884 EP - 9 JF - Archives of pharmacal research JO - Arch Pharm Res VL - 30 IS - 7 N2 - A new plant gum, Okra (extracted from the pods of Hibiscus esculentus), has been evaluated as a controlled-release agent in modified release matrices, in comparison with sodium carboxymethyl cellulose (NaCMC) and hydroxypropylmethyl cellulose (HPMC), using Paracetamol as a model drug. Tablets were produced by direct compression and the in-vitro drug release was assessed in conditions mimicking the gastro intestinal system, for 6 h. Okra gum matrices provided a controlled-release of Paracetamol for more than 6 h and the release rates followed time-independent kinetics. The release rates were dependent on the concentration of the drug present in the matrix. The addition of tablet excipients, lactose and Avicel, altered the dissolution profile and the release kinetics. Okra gum compared favourably with NaCMC, and a combination of Okra gum and NaCMC, or on further addition of HPMC resulted in near zeroorder release of paracetamol from the matrix tablet. The results indicate that Okra gum matrices could be useful in the formulation of sustained-release tablets for up to 6 h. SN - 0253-6269 UR - https://www.unboundmedicine.com/medline/citation/17703742/Matrix_properties_of_a_new_plant_gum_in_controlled_drug_delivery_ L2 - http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=linkout&SEARCH=17703742.ui DB - PRIME DP - Unbound Medicine ER -