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Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis.
Cytokine. 2007 Aug; 39(2):138-41.C

Abstract

Eosinophilic meningitis associated angiostrongyliasis (EOMA) is a harmful disease of the brain and spinal cord caused by a parasitic helminth, Angiostrongylus cantonensis, presenting with severe headaches and cerebrospinal fluid (CSF) eosinophilia. However, the immunologic pathophysiology especially in relation to the eosinophilic inflammation is still unknown. We measured the CSF concentrations of eotaxin and eotaxin-2 of 30 patients and 10 controls. The CSF eotaxin and eotaxin-2 levels of the EOMA patients were significantly higher than those of the controls (p<0.001). The positive detection values were 83.3% (25/30) and 93.3% (28/30) for eotaxin and eotaxin-2, respectively. CSF eotaxin-2 levels also correlated with CSF eosinophilia (p=0.002). These results might indicate that the recruitment of eosinophils to the brain and spinal cord in EOMA patients could be related to elevated eotaxin-2 levels.

Authors+Show Affiliations

Department of Parasitology, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand. pewpa@kku.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

17703945

Citation

Intapan, Pewpan M., et al. "Cerebrospinal Fluid Eotaxin and Eotaxin-2 Levels in Human Eosinophilic Meningitis Associated With Angiostrongyliasis." Cytokine, vol. 39, no. 2, 2007, pp. 138-41.
Intapan PM, Niwattayakul K, Sawanyawisuth K, et al. Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. Cytokine. 2007;39(2):138-41.
Intapan, P. M., Niwattayakul, K., Sawanyawisuth, K., Chotmongkol, V., & Maleewong, W. (2007). Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. Cytokine, 39(2), 138-41.
Intapan PM, et al. Cerebrospinal Fluid Eotaxin and Eotaxin-2 Levels in Human Eosinophilic Meningitis Associated With Angiostrongyliasis. Cytokine. 2007;39(2):138-41. PubMed PMID: 17703945.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cerebrospinal fluid eotaxin and eotaxin-2 levels in human eosinophilic meningitis associated with angiostrongyliasis. AU - Intapan,Pewpan M, AU - Niwattayakul,Kanigar, AU - Sawanyawisuth,Kittisak, AU - Chotmongkol,Verajit, AU - Maleewong,Wanchai, Y1 - 2007/08/20/ PY - 2007/04/03/received PY - 2007/06/15/revised PY - 2007/06/22/accepted PY - 2007/8/21/pubmed PY - 2008/1/19/medline PY - 2007/8/21/entrez SP - 138 EP - 41 JF - Cytokine JO - Cytokine VL - 39 IS - 2 N2 - Eosinophilic meningitis associated angiostrongyliasis (EOMA) is a harmful disease of the brain and spinal cord caused by a parasitic helminth, Angiostrongylus cantonensis, presenting with severe headaches and cerebrospinal fluid (CSF) eosinophilia. However, the immunologic pathophysiology especially in relation to the eosinophilic inflammation is still unknown. We measured the CSF concentrations of eotaxin and eotaxin-2 of 30 patients and 10 controls. The CSF eotaxin and eotaxin-2 levels of the EOMA patients were significantly higher than those of the controls (p<0.001). The positive detection values were 83.3% (25/30) and 93.3% (28/30) for eotaxin and eotaxin-2, respectively. CSF eotaxin-2 levels also correlated with CSF eosinophilia (p=0.002). These results might indicate that the recruitment of eosinophils to the brain and spinal cord in EOMA patients could be related to elevated eotaxin-2 levels. SN - 1043-4666 UR - https://www.unboundmedicine.com/medline/citation/17703945/Cerebrospinal_fluid_eotaxin_and_eotaxin_2_levels_in_human_eosinophilic_meningitis_associated_with_angiostrongyliasis_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1043-4666(07)00165-2 DB - PRIME DP - Unbound Medicine ER -