Tags

Type your tag names separated by a space and hit enter

Effects of continuous enteral L-arginine in a rat model of the short bowel syndrome.
Asia Pac J Clin Nutr. 2007; 16(3):554-60.AP

Abstract

The objective of this study was to evaluate whether continuous enteral supplementation of L-arginine can stimulate intestinal adaptation in a rat model of short bowel syndrome (SBS). Male Sprague-Dawley rats were randomly divided into three groups of 10 each: Sham rats underwent bowel transaction and received continuous enteral nutrition (Control group, Con group), SBS rats underwent 75% small bowel resection and received continuous enteral nutrition (SB group), and SBS rats underwent 75% bowel resection and received continuous enteral nutrition supplemented with L-arginine (300 mg/Kg/d) (SB-Arg group). Fat absorbability, plasma free fatty acids, parameters of intestinal adaptation, enterocyte proliferation and apoptosis were determined on day 15 after operation. After massive small bowel resection, rats had significant bowel adaptation. Compared with SB untreated rats, SB rats supplemented with L-arginine demonstrated a significant increase in fat absorbability, plasma level of free fatty acids, ileal mucosal weight and DNA content, jejunal and ileal mucosal protein content, jejunal and ileal villus length, crypt depth and mucosal thickness. L-arginine supplementation increased enterocyte proliferation, while decreasing enterocyte apoptosis. We suggest that after massive small bowel resection, continuous enteral supplementation of L-arginine can stimulate intestinal adaptation. L-arginine may be a trophic factor to stimulate intestinal adaptation in rats of SBS.

Authors+Show Affiliations

Department of General Surgery, Zhongda Hospital, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China. jxh@medmail.com.cnNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17704037

Citation

Jiang, Xiaohua, et al. "Effects of Continuous Enteral L-arginine in a Rat Model of the Short Bowel Syndrome." Asia Pacific Journal of Clinical Nutrition, vol. 16, no. 3, 2007, pp. 554-60.
Jiang X, Zhu W, Li N, et al. Effects of continuous enteral L-arginine in a rat model of the short bowel syndrome. Asia Pac J Clin Nutr. 2007;16(3):554-60.
Jiang, X., Zhu, W., Li, N., Tan, L., & Li, J. (2007). Effects of continuous enteral L-arginine in a rat model of the short bowel syndrome. Asia Pacific Journal of Clinical Nutrition, 16(3), 554-60.
Jiang X, et al. Effects of Continuous Enteral L-arginine in a Rat Model of the Short Bowel Syndrome. Asia Pac J Clin Nutr. 2007;16(3):554-60. PubMed PMID: 17704037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of continuous enteral L-arginine in a rat model of the short bowel syndrome. AU - Jiang,Xiaohua, AU - Zhu,Weiming, AU - Li,Ning, AU - Tan,Li, AU - Li,Jieshou, PY - 2007/8/21/pubmed PY - 2007/12/8/medline PY - 2007/8/21/entrez SP - 554 EP - 60 JF - Asia Pacific journal of clinical nutrition JO - Asia Pac J Clin Nutr VL - 16 IS - 3 N2 - The objective of this study was to evaluate whether continuous enteral supplementation of L-arginine can stimulate intestinal adaptation in a rat model of short bowel syndrome (SBS). Male Sprague-Dawley rats were randomly divided into three groups of 10 each: Sham rats underwent bowel transaction and received continuous enteral nutrition (Control group, Con group), SBS rats underwent 75% small bowel resection and received continuous enteral nutrition (SB group), and SBS rats underwent 75% bowel resection and received continuous enteral nutrition supplemented with L-arginine (300 mg/Kg/d) (SB-Arg group). Fat absorbability, plasma free fatty acids, parameters of intestinal adaptation, enterocyte proliferation and apoptosis were determined on day 15 after operation. After massive small bowel resection, rats had significant bowel adaptation. Compared with SB untreated rats, SB rats supplemented with L-arginine demonstrated a significant increase in fat absorbability, plasma level of free fatty acids, ileal mucosal weight and DNA content, jejunal and ileal mucosal protein content, jejunal and ileal villus length, crypt depth and mucosal thickness. L-arginine supplementation increased enterocyte proliferation, while decreasing enterocyte apoptosis. We suggest that after massive small bowel resection, continuous enteral supplementation of L-arginine can stimulate intestinal adaptation. L-arginine may be a trophic factor to stimulate intestinal adaptation in rats of SBS. SN - 0964-7058 UR - https://www.unboundmedicine.com/medline/citation/17704037/Effects_of_continuous_enteral_L_arginine_in_a_rat_model_of_the_short_bowel_syndrome_ L2 - http://apjcn.nhri.org.tw/server/APJCN/16/3/554.pdf DB - PRIME DP - Unbound Medicine ER -