Tags

Type your tag names separated by a space and hit enter

Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba.
Phytother Res. 2008 Feb; 22(2):256-8.PR

Abstract

The neurosedative and antioxidative properties of some major compounds isolated from a citral chemotype of Lippia alba were investigated. Binding assays were performed on two CNS inhibitory targets: benzodiazepine and GABA(A) receptors. The most active compound was luteolin-7-diglucuronide, with half maximal inhibitory concentrations (IC(50)) of 101 and 40 microm, respectively. Fifteen compounds isolated from Lippia alba were tested for their radical scavenging capacities against DPPH. Four of the major compounds (verbascoside, calceolarioside E, luteolin-7-diglucuronide and theveside) were also tested for their antioxidant activity against superoxide radical-anion in cell-free (hypoxanthine-xanthine oxidase) and cellular (PMA-stimulated neutrophil granulocytes) systems.

Authors+Show Affiliations

Laboratoire de Pharmacognosie, EA 1043, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Lille 2, Lille, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

17705148

Citation

Hennebelle, Thierry, et al. "Antioxidant and Neurosedative Properties of Polyphenols and Iridoids From Lippia Alba." Phytotherapy Research : PTR, vol. 22, no. 2, 2008, pp. 256-8.
Hennebelle T, Sahpaz S, Gressier B, et al. Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba. Phytother Res. 2008;22(2):256-8.
Hennebelle, T., Sahpaz, S., Gressier, B., Joseph, H., & Bailleul, F. (2008). Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba. Phytotherapy Research : PTR, 22(2), 256-8.
Hennebelle T, et al. Antioxidant and Neurosedative Properties of Polyphenols and Iridoids From Lippia Alba. Phytother Res. 2008;22(2):256-8. PubMed PMID: 17705148.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and neurosedative properties of polyphenols and iridoids from Lippia alba. AU - Hennebelle,Thierry, AU - Sahpaz,Sevser, AU - Gressier,Bernard, AU - Joseph,Henry, AU - Bailleul,François, PY - 2007/8/21/pubmed PY - 2008/6/25/medline PY - 2007/8/21/entrez SP - 256 EP - 8 JF - Phytotherapy research : PTR JO - Phytother Res VL - 22 IS - 2 N2 - The neurosedative and antioxidative properties of some major compounds isolated from a citral chemotype of Lippia alba were investigated. Binding assays were performed on two CNS inhibitory targets: benzodiazepine and GABA(A) receptors. The most active compound was luteolin-7-diglucuronide, with half maximal inhibitory concentrations (IC(50)) of 101 and 40 microm, respectively. Fifteen compounds isolated from Lippia alba were tested for their radical scavenging capacities against DPPH. Four of the major compounds (verbascoside, calceolarioside E, luteolin-7-diglucuronide and theveside) were also tested for their antioxidant activity against superoxide radical-anion in cell-free (hypoxanthine-xanthine oxidase) and cellular (PMA-stimulated neutrophil granulocytes) systems. SN - 0951-418X UR - https://www.unboundmedicine.com/medline/citation/17705148/Antioxidant_and_neurosedative_properties_of_polyphenols_and_iridoids_from_Lippia_alba_ L2 - https://doi.org/10.1002/ptr.2266 DB - PRIME DP - Unbound Medicine ER -